Epithelioid angiomyolipoma mimicking adrenal cortical carcinoma: A diagnostic pitfall

Komarowska,Hanna; Bednarek‑Rajewska,Katarzyna; Kański,Marcin; Janicka‑Jedyńska,Małgorzata; Gut,Paweł; Ruchała,Marek

doi:10.3892/ol.2015.3543

October-2015 Volume 10 Issue 4

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October-2015 Volume 10 Issue 4

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Epithelioid angiomyolipoma mimicking adrenal cortical carcinoma: A diagnostic pitfall

Authors:
- Hanna Komarowska
- Katarzyna Bednarek‑Rajewska
- Marcin Kański
- Małgorzata Janicka‑Jedyńska
- Paweł Gut
- Marek Ruchała
View Affiliations / Copyright

Affiliations: Department of Endocrinology, Metabolism and Internal Medicine, Poznań University of Medical Sciences, Poznań 60‑355, Poland, Department of Clinical Pathomorphology, Poznań University of Medical Sciences, Poznań 60‑355, Poland, Department of Geriatric Medicine and Gerontology, Poznań University of Medical Sciences, Poznań 60‑355, Poland

Copyright: © Komarowska et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 2130-2134
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Published online on: July 29, 2015

https://doi.org/10.3892/ol.2015.3543
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Abstract

Epithelioid angiomyolipoma (EAML) is a rare mesenchymal neoplasmic variant of angiomyolipoma characterized by aggressive growth and unpredictable outcome. Cases of local recurrence and distant metastasis have been described. The histopathological diagnosis may be difficult, as EAML often mimics other neoplasms. This is the case report of a 39‑year‑old male patient with EAML, which was initially diagnosed as adrenal cortical carcinoma, due to the lack of cooperation between clinicians and pathologists.

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1	Martignoni G and Amin MB: Angiomyolipoma. In: WHO Classification of Tumours. Pathology and GeneticsTumours of the Urinary System and Male Genital Organs. Eble JN, Sauter G, Epstein JI and Sesterhenn IA: IARC Press; Lyon, France: pp. 63–67. 2004
2	Amin MB: Epithelioid angiomyolipoma. In: WHO Classification of Tumours. Pathology and GeneticsTumours of the Urinary System and Male Genital Organs. Eble JN, Sauter G, Epstein JI and Sesterhenn IA: IARC Press; Lyon, France: pp. 68–69. 2004
3	Mete O and van der Kwast TH: Epithelioid angiomyolipoma: A morphologically distinct variant that mimics a variety of intra-abdominal neoplasms. Arch Pathol Lab Med. 135:665–670. 2011.PubMed/NCBI
4	Eble JN, Amin MB and Young RH: Epithelioid angiomyolipoma of the kidney: A report of five cases with a prominent and diagnostically confusing epithelioid smooth muscle component. Am J Surg Pathol. 21:1123–1130. 1997. View Article : Google Scholar : PubMed/NCBI
5	Hornik JL and Fletcher CD: PEComa: What do we know so far? Histopathology. 48:75–82. 2006. View Article : Google Scholar : PubMed/NCBI
6	Nelson CP and Sanda MG: Contemporary diagnosis and management of renal angiomyolipoma. J Urol. 168:1315–1325. 2002. View Article : Google Scholar : PubMed/NCBI
7	Nese N, Martignoni G, Fletcher CD, et al: Pure epithelioid PEComas (so-called epithelioid angiomyolipoma) of the kidney: A clinicopathologic study of 41 cases: Detailed assessment of morphology and risk stratification. Am J Surg Pathol. 35:161–176. 2011. View Article : Google Scholar : PubMed/NCBI
8	Sangoi AR, Fujiwara M, West RB, Montgomery KD, Bonventre JV, Higgins JP, Rouse RV, Gokden N and McKenney JK: Immunohistochemical distinction of primary adrenal cortical lesions from metastatic clear cell renal cell carcinoma: A study of 248 cases. Am J Surg Pathol. 35:678–686. 2011. View Article : Google Scholar : PubMed/NCBI
9	Fulawka L, Patrzalek D and Halon A: Adrenal cortical carcinoma with extension into the inferior vena cava - case report and literature review. Diagn Pathol. 9:512014. View Article : Google Scholar : PubMed/NCBI
10	Lane BR, Aydin H, Danforth TL, Zhou M, Remer EM, Novick AC and Campbell SC: Clinical correlates of renal angiomyolipoma subtypes in 209 patients: classic, fat poor, tuberous sclerosis associated and ephitelioid. J Urol. 180:836–843. 2008. View Article : Google Scholar : PubMed/NCBI
11	Wyluda E, Baqero G, Lamparella N, Abendroth C and Drabick J: Fatal malignant metastastic epithelioid angiomyolipoma presenting in a young woman: Case report and review of the literature. Rare Tumors. 5:e462013. View Article : Google Scholar : PubMed/NCBI
12	Allolio B and Fassnacht M: Clinical review: Adrenocortical carcinoma: Clinical update. J Clin Endocrinol Metab. 91:2027–2037. 2006. View Article : Google Scholar : PubMed/NCBI
13	Bertherat J and Bertagna X: Pathogenesis of adrenocortical cancer. Best Pract Res Clin Endocrinol Metab. 23:261–271. 2009. View Article : Google Scholar : PubMed/NCBI
14	Lafemina J and Brennan MF: Adrenocortical carcinoma: Past, present and future. J Surg Oncol. 106:586–594. 2012. View Article : Google Scholar : PubMed/NCBI
15	Fassnacht M, Johanssen S, Quinkler M, Bucsky P, Willenberg HS, Beuschlein F, Terzolo M, Mueller HH, Hahner S and Allolio B: German Adrenocortical Carcinoma Registry Group; European Network for the Study of Adrenal Tumors: Limited prognostic value of the 2004 International Union Against Cancer staging classification for adrenocortical carcinoma: Proposal for a Revised TNM Classification. Cancer. 115:243–250. 2009. View Article : Google Scholar : PubMed/NCBI
16	Aubert S, Wacrenier A, Leroy X, Devos P, Carnaille B, Proye C, Wemeau JL, LecomteHoucke M and Leteurtre E: Weiss system revisited: a clinicopathologic and immunohistochemical study of 49 adrenocortical tumors. Am J Surg Pathol. 26:1612–1619. 2002. View Article : Google Scholar : PubMed/NCBI
17	Fassnacht M and Allolio B: Clinical management of adrenocortical carcinoma. Best Pract Res Clin Endocrinol Metab. 23:273–289. 2009. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Epithelioid angiomyolipoma mimicking adrenal cortical carcinoma: A diagnostic pitfall

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