Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2015 Volume 10 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2015 Volume 10 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China

  • Authors:
    • Yingying Xiang
    • Kuailu Lin
    • Siyang Dong
    • Li Qiao
    • Qiuxiang He
    • Xiaohua Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
  • Pages: 2559-2564
    |
    Published online on: July 29, 2015
       https://doi.org/10.3892/ol.2015.3544
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Central lymph node metastasis (CLNM) is common in papillary thyroid microcarcinoma (PTMC). The aim of the present study was to investigate the risk factors associated with CLNM in clinical lateral cervical lymph node‑negative (cN0) PTMC in Eastern China. A total of 392 patients with confirmed PTMC by histological examination who underwent thyroidectomy and central neck lymph node dissection (CND) between May 2011 and October 2012 at the First Affiliated Hospital of Wenzhou Medical University (Wenzhou, China) were enrolled. The clinicopathological and ultrasonographic data from the patients were analyzed retrospectively. A scoring system was developed on the basis of independent predictive factors for CLNM. Male gender, age <45 years, maximum tumor diameter >5 mm, lower lobe location, multifocal carcinoma with total tumor diameter >10 mm and extracapsular spread were independent predictive factors for CLNM according to logistic regression analysis. The clinicopathological score was statistically significant, with an index point ≥2 indicating CLNM with 86.2% sensitivity and 70.4% specificity. The findings of the present study indicate that CND may be recommended to be routinely performed when the clinicopathological index point ≥2.
View Figures

Figure 1

View References

1 

Hedinger C, Williams ED and Sobin LH: The WHO histological classification of thyroid tumors: A commentary on the second edition. Cancer. 63:908–911. 1989. View Article : Google Scholar : PubMed/NCBI

2 

Xiang J, Wu Y, Li DS, Shen Q, Wang ZY, Sun TQ, An Y and Guan Q: New clinical features of thyroid cancer in eastern China. J Visc Surg. 147:e53–e56. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Cheng P, Chen ED, Zheng HM, He QX and Li Q: Ultrasound score to select subcentimeter-sized thyroid nodules requiring ultrasound-guided fine needle aspiration biopsy in eastern China. Asian Pac J Cancer Prev. 14:4689–4692. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Baudin E, Travagli JP, Ropers J, Mancusi F, BrunoBossio G, Caillou B, Cailleux AF, Lumbroso JD, Parmentier C and Schlumberger M: Microcarcinoma of the thyroid gland: The gustave-roussy institute experience. Cancer. 83:553–559. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Hay ID, Grant CS, van Heerden JA, Goellner Jr, Ebersold JR and Bergstralh EJ: Papillary thyroid microcarcinoma: A study of 535 cases observed in a 50-year period. Surgery. 112:1139–1146; discussion 1146–1147. 1992.PubMed/NCBI

6 

Yamashita H, Noguchi S, Murakami N, Toda M, Uchino S, Watanabe S and Kawamoto H: Extracapsular invasion of lymph node metastasis. A good indicator of disease recurrence and poor prognosis in patients with thyroid microcarcinoma. Cancer. 86:842–849. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Chow SM, Law SC, Chan JK, Au SK, Yau S and Lau WH: Papillary microcarcinoma of the thyroid-Prognostic significance of lymph node metastasis and multifocality. Cancer. 98:31–40. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Moo TA, McGill J, Allendorf J, Lee J, Fahey T III and Zarnegar R: Impact of prophylactic central neck lymph node dissection on early recurrence in papillary thyroid carcinoma. World J Surg. 34:1187–1191. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, et al: American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer1; Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 19:1167–1214. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Kowalski LP, Bagietto R, Lara JR, Santos RL, Silva JF Jr and Magrin J: Prognostic significance of the distribution of neck node metastasis from oral carcinoma. Head Neck. 22:207–214. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Xie WC, Chan MH, Mak KC, Chan WT and He M: Trends in the incidence of 15 common cancers in Hong Kong, 1983–2008. Asian Pac J Cancer Prev. 13:3911–3916. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Kutler DI, Crummey AD and Kuhel WI: Routine central compartment lymph node dissection for patients with papillary thyroid carcinoma. Head Neck. 34:260–263. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Moo TA, Umunna B, Kato M, Butriago D, Kundel A, Lee JA, Zarnegar R and Fahey TJ III: Ipsilateral versus bilateral central neck lymph node dissection in papillary thyroid carcinoma. Ann Surg. 250:403–408. 2009.PubMed/NCBI

14 

Sadowski BM, Snyder SK and Lairmore TC: Routine bilateral central lymph node clearance for papillary thyroid cancer. Surgery. 146:696–703; discussion 703–695. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Lee YS, Lim YS, Lee JC, Wang SG, Kim IJ and Lee BJ: Clinical implication of the number of central lymph node metastasis in papillary thyroid carcinoma: Preliminary report. World J Surg. 34:2558–2563. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Lim YS, Lee JC, Lee YS, Lee BJ, Wang SG, Son SM and Kim IJ: Lateral cervical lymph node metastases from papillary thyroid carcinoma: Predictive factors of nodal metastasis. Surgery. 150:116–121. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Xiao GZ and Gao L: Central lymph node metastasis: Is it a reliable indicator of lateral node involvement in papillary thyroid carcinoma? World J Surg. 34:237–241. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Ito Y, Higashiyama T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Kuma K and Miyauchi A: Risk factors for recurrence to the lymph node in papillary thyroid carcinoma patients without preoperatively detectable lateral node metastasis: validity of prophylactic modified radical neck dissection. World J Surg. 31:2085–2091. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Suliburk J and Delbridge L: Surgical management of well-differentiated thyroid cancer: state of the art. Surg Clin North Am. 89:1171–1191. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Ito Y, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Kuma K and Miyauchi A: Clinical significance of metastasis to the central compartment from papillary microcarcinoma of the thyroid. World J Surg. 30:91–99. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Zhang L, Wei WJ, Ji QH, Zhu YX, Wang ZY, Wang Y, Huang CP, Shen Q, Li DS and Wu Y: Risk factors for neck nodal metastasis in papillary thyroid microcarcinoma: a study of 1066 patients. J Clin Endocrinol Metab. 97:1250–1257. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Kim BY, Jung CH, Kim JW, Lee SW, Kim CH, Kang SK and Mok JO: Impact of clinicopathologic factors on subclinical central lymph node metastasis in papillary thyroid microcarcinoma. Yonsei Med J. 53:924–930. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Zeng RC, Li Q, Lin KL, Zhang W, Gao EL, Huang GL, Zhang XH and Zheng MH: Predicting the factors of lateral lymph node metastasis in papillary microcarcinoma of the thyroid in eastern China. Clin Transl Oncol. 14:842–847. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Kim KE, Kim EK, Yoon JH, Han KH, Moon HJ and Kwak JY: Preoperative prediction of central lymph node metastasis in thyroid papillary microcarcinoma using clinicopathologic and sonographic features. World J Surg. 37:385–391. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Lim YC, Choi EC, Yoon YH, Kim EH and Koo BS: Central lymph node metastases in unilateral papillary thyroid microcarcinoma. Br J Surg. 96:253–257. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Wang W, Gu J, Shang J and Wang K: Correlation analysis on central lymph node metastasis in 276 patients with cN0 papillary thyroid carcinoma. Int J Clin Exp Pathol. 6:510–515. 2013.PubMed/NCBI

27 

So YK, Son YI, Hong SD, Seo MY, Baek CH, Jeong HS and Chung MK: Subclinical lymph node metastasis in papillary thyroid microcarcinoma: A study of 551 resections. Surgery. 148:526–531. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Lee KJ, Cho YJ, Kim SJ, Lee SC, Kim JG, Ahn CJ and Lee DH: Analysis of the clinicopathologic features of papillary thyroid microcarcinoma based on 7-mm tumor size. World J Surg. 35:318–323. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Kwak JY, Kim EK, Kim MJ, Son EJ, Chung WY, Park CS and Nam KH: Papillary microcarcinoma of the thyroid: Predicting factors of lateral neck node metastasis. Ann Surg Oncol. 16:1348–1355. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Choi YJ, Yun JS, Kook SH, Jung EC and Park YL: Clinical and imaging assessment of cervical lymph node metastasis in papillary thyroid carcinomas. World J Surg. 34:1494–1499. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Zhao Q, Ming J, Liu C, Shi L, Xu X, Nie X and Huang T: Multifocality and total tumor diameter predict central neck lymph node metastases in papillary thyroid microcarcinoma. Ann Surg Oncol. 20:746–752. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Gulben K, Berberoğlu U, Celen O and Mersin HH: Incidental papillary microcarcinoma of the thyroid-factors affecting lymph node metastasis. Langenbecks Arch Surg. 393:25–29. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Kim HS, Choi YJ and Yun JS: Features of papillary thyroid microcarcinoma in the presence and absence of lymphocytic thyroiditis. Endocr Pathol. 21:149–153. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Lin KL, Wang OC, Zhang XH, Dai XX, Hu XQ and Qu JM: The BRAF mutation is predictive of aggressive clinicopathological characteristics in papillary thyroid microcarcinoma. Ann Surg Oncol. 17:3294–3300. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Kim SS, Lee BJ, Lee JC, Kim SJ, Jeon YK, Kim MR, Huh JE, Mok JY, Kim BH, Kim YK and Kim IJ: Coexistence of Hashimoto's thyroiditis with papillary thyroid carcinoma: The influence of lymph node metastasis. Head Neck. 33:1272–1277. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xiang Y, Lin K, Dong S, Qiao L, He Q and Zhang X: Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China. Oncol Lett 10: 2559-2564, 2015.
APA
Xiang, Y., Lin, K., Dong, S., Qiao, L., He, Q., & Zhang, X. (2015). Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China. Oncology Letters, 10, 2559-2564. https://doi.org/10.3892/ol.2015.3544
MLA
Xiang, Y., Lin, K., Dong, S., Qiao, L., He, Q., Zhang, X."Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China". Oncology Letters 10.4 (2015): 2559-2564.
Chicago
Xiang, Y., Lin, K., Dong, S., Qiao, L., He, Q., Zhang, X."Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China". Oncology Letters 10, no. 4 (2015): 2559-2564. https://doi.org/10.3892/ol.2015.3544
Copy and paste a formatted citation
x
Spandidos Publications style
Xiang Y, Lin K, Dong S, Qiao L, He Q and Zhang X: Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China. Oncol Lett 10: 2559-2564, 2015.
APA
Xiang, Y., Lin, K., Dong, S., Qiao, L., He, Q., & Zhang, X. (2015). Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China. Oncology Letters, 10, 2559-2564. https://doi.org/10.3892/ol.2015.3544
MLA
Xiang, Y., Lin, K., Dong, S., Qiao, L., He, Q., Zhang, X."Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China". Oncology Letters 10.4 (2015): 2559-2564.
Chicago
Xiang, Y., Lin, K., Dong, S., Qiao, L., He, Q., Zhang, X."Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China". Oncology Letters 10, no. 4 (2015): 2559-2564. https://doi.org/10.3892/ol.2015.3544
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team