Long non‑coding RNA growth arrest-specific transcript 5 in tumor biology (Review)

  • Authors:
    • Xin Yu
    • Zheng Li
  • View Affiliations

  • Published online on: July 30, 2015     https://doi.org/10.3892/ol.2015.3553
  • Pages: 1953-1958
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The recognition of the biological relevance of long non‑coding RNA (lncRNA) molecules has only recently been recognized as one of the most significant advances in contemporary molecular biology. A growing body of evidence indicates that lncRNAs act not only as the intermediary between DNA and protein but also as significant protagonists of cellular functions. The dysregulation of lncRNAs has increasingly been linked to numerous human diseases, particularly cancers. Recent studies have demonstrated that the lncRNA growth arrest-specific transcript 5 (GAS5) was pervasively downexpressed in most human cancers compared with non‑cancerous adjacent tissues including gastric, breast, lung and prostate cancer. In addition, patients with decreased GAS5 expression have a significantly poorer prognosis than those with higher expression. Furthermore, GAS5 is involved in the control of cell apoptosis, proliferation, metastasis, angiogenesis, DNA repair and tumor cell metabolism. This review provides an overview of the current knowledge concerning the role of GAS5 in tumor expression and biology function.
View Figures
View References

Related Articles

Journal Cover

October 2015
Volume 10 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Yu, X., & Yu, X. (2015). Long non‑coding RNA growth arrest-specific transcript 5 in tumor biology (Review). Oncology Letters, 10, 1953-1958. https://doi.org/10.3892/ol.2015.3553
MLA
Yu, X., Li, Z."Long non‑coding RNA growth arrest-specific transcript 5 in tumor biology (Review)". Oncology Letters 10.4 (2015): 1953-1958.
Chicago
Yu, X., Li, Z."Long non‑coding RNA growth arrest-specific transcript 5 in tumor biology (Review)". Oncology Letters 10, no. 4 (2015): 1953-1958. https://doi.org/10.3892/ol.2015.3553