Gene expression profiling and its use in adenocarcinomas of unknown primary origin: A case report

  • Authors:
    • Ana Cebollero de Miguel
    • Roberto Pazo Cid
    • Javier Martinez Trufero
    • Isabel Pajares Bernad
    • Lourdes Calera Urquizu
    • Jorge Hernando Cubero
    • Antonio Anton Torres
  • View Affiliations

  • Published online on: August 4, 2015     https://doi.org/10.3892/ol.2015.3572
  • Pages: 2657-2661
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Carcinomas of unknown primary origin account for 3‑5% of all malignancies. The current literature suggests that metastatic dissemination is able to occur in the absence of primary tumor growth. In metastatic disease that is difficult to diagnose, the origin usually remains unknown even after an exhaustive evaluation of immunohistochemistry (IHC) markers. In the current study, a 49‑year‑old male presented with lymph nodes metastases of unknown origin. The excisional biopsy of an inguinal node revealed an adenocarcinoma growth pattern, but the IHC could not determine the primary origin. A gene profiling test was performed to complete the diagnosis and a salivary gland adenocarcinoma was diagnosed with 90% probability. Subsequently, the patient underwent appropriate chemotherapy for salivary gland adenocarcinoma, and exhibited an improved partial response. The present case study highlights the importance of an accurate diagnosis of the primary tumor and the use of all the current tools available in order to provide patients with the best treatment possible.
View Figures
View References

Related Articles

Journal Cover

October-2015
Volume 10 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
de Miguel AC, Cid RP, Trufero JM, Bernad IP, Urquizu LC, Cubero JH and Torres AA: Gene expression profiling and its use in adenocarcinomas of unknown primary origin: A case report. Oncol Lett 10: 2657-2661, 2015
APA
de Miguel, A.C., Cid, R.P., Trufero, J.M., Bernad, I.P., Urquizu, L.C., Cubero, J.H., & Torres, A.A. (2015). Gene expression profiling and its use in adenocarcinomas of unknown primary origin: A case report. Oncology Letters, 10, 2657-2661. https://doi.org/10.3892/ol.2015.3572
MLA
de Miguel, A. C., Cid, R. P., Trufero, J. M., Bernad, I. P., Urquizu, L. C., Cubero, J. H., Torres, A. A."Gene expression profiling and its use in adenocarcinomas of unknown primary origin: A case report". Oncology Letters 10.4 (2015): 2657-2661.
Chicago
de Miguel, A. C., Cid, R. P., Trufero, J. M., Bernad, I. P., Urquizu, L. C., Cubero, J. H., Torres, A. A."Gene expression profiling and its use in adenocarcinomas of unknown primary origin: A case report". Oncology Letters 10, no. 4 (2015): 2657-2661. https://doi.org/10.3892/ol.2015.3572