A single center clinical analysis of children with neuroblastoma

  • Authors:
    • Jing‑Bo Shao
    • Zheng‑Hua Lu
    • Wen‑Yan Huang
    • Zhi‑Bao Lv
    • Hui Jiang
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  • Published online on: August 11, 2015     https://doi.org/10.3892/ol.2015.3588
  • Pages: 2311-2318
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Abstract

In the present study, the cases of 59 children diagnosed with neuroblastoma (NB) were retrospectively analyzed to assess the association between the short‑term efficacy of treatment and prognostic factors. In total, 59 patients with NB that were diagnosed between July 1, 2008 and June 30, 2013 at Shanghai Children's Hospital were enrolled in the present study. The follow‑up was performed until December 31, 2013, and the data revealed that 43 patients (72.9%) achieved complete remission (CR) or partial remission (PR). The 3‑year overall survival (OS) rate of patients with stage I, II, III, IV and IVs disease was 100, 100, 65.6, 34.8 and 85.7%, respectively (P=0.02). The 3‑year OS and event‑free survival rates were evidently increased in patients with favorable histology compared with the rates in the patients with unfavorable histology (P=0.046 and 0.030, respectively). Univariate statistical analysis revealed that the factors significantly associated with prognosis were patient age, tumor stage and risk group (P=0.004, 0.02 and 0.001, respectively). The present study identified that tumor stage, risk group and patient age are important prognostic factors for NB. An age of 18 months was also hypothesized to be the cut‑off for the prognosis of patients.
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October-2015
Volume 10 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Shao JB, Lu ZH, Huang WY, Lv ZB and Jiang H: A single center clinical analysis of children with neuroblastoma. Oncol Lett 10: 2311-2318, 2015
APA
Shao, J., Lu, Z., Huang, W., Lv, Z., & Jiang, H. (2015). A single center clinical analysis of children with neuroblastoma. Oncology Letters, 10, 2311-2318. https://doi.org/10.3892/ol.2015.3588
MLA
Shao, J., Lu, Z., Huang, W., Lv, Z., Jiang, H."A single center clinical analysis of children with neuroblastoma". Oncology Letters 10.4 (2015): 2311-2318.
Chicago
Shao, J., Lu, Z., Huang, W., Lv, Z., Jiang, H."A single center clinical analysis of children with neuroblastoma". Oncology Letters 10, no. 4 (2015): 2311-2318. https://doi.org/10.3892/ol.2015.3588