Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2015 Volume 10 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2015 Volume 10 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

FOLFIRINOX‑induced reversible dysarthria: A case report and review of previous cases

  • Authors:
    • Ayumu Matsuoka
    • Osamu Maeda
    • Megumi Inada‑Inoue
    • Eizaburo Ohno
    • Yoshiki Hirooka
    • Yukihiro Yokoyama
    • Tsutomu Fujii
    • Masato Nagino
    • Hidemi Goto
    • Yuichi Ando
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Aichi 466‑8550, Japan, Department of Endoscopy, Nagoya University Hospital, Nagoya, Aichi 466‑8550, Japan, Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan, Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan, Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan
  • Pages: 2662-2664
    |
    Published online on: August 11, 2015
       https://doi.org/10.3892/ol.2015.3591
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

FOLFIRINOX is a standard chemotherapeutic regimen for patients with advanced pancreatic cancer who have a good performance status. In this study, we present the case of a 64‑year‑old male who developed dysarthria following FOLFIRINOX treatment, and review all four cases of dysarthria encountered among the nine patients who received this treatment in our hospital. In all cases, dysarthria occurred during the infusion of irinotecan in the first course of treatment, persisted for several hours, and then resolved rapidly without any sequelae. Physical and neurological examinations at the onset of dysarthria revealed no other abnormalities. Imaging studies revealed no abnormal findings. Atropine was prophylactically administered in the second and subsequent courses of treatment and effectively prevented or alleviated dysarthria. This acute neurological symptom is surprising and uncommon in traditional cancer chemotherapy, and medical oncologists may initially suspect the onset of stroke or cerebrovascular disease. However, consistent with our experience, all reported cases resolved completely, with no need for dose reduction or treatment interruption.
View Figures
View References

1 

Conroy T, Desseigne F, Ychou M, Bouché O, Guimbaud R, Bécouarn Y, Adenis A, Raoul JL, Gourgou-Bourgade S, de la Fouchardière C, et al: FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 364:1817–1825. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Hamberg P, De Jong FA, Brandsma D, Verweij J and Sleijfer S: Irinotecan-induced central nervous system toxicity. Report on two cases and review of the literature. Acta Oncol. 47:974–978. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Sogabe S, Yuki S, Takano H, Kobayashi Y, Nakatsumi H, Sasaki T, Kawamoto Y, Fukushima H, Iwanaga I, Uehata Y, et al: A case of sigmoid colon cancer with temporary dysarthria associated with irinotecan. Gan To Kagaku Ryoho. 38:1375–1377. 2011.(In Japanese). PubMed/NCBI

4 

Gunturu KS, Yao X, Cong X, Thumar JR, Hochster HS, Stein SM and Lacy J: FOLFIRINOX for locally advanced and metastatic pancreatic cancer: single institution retrospective review of efficacy and toxicity. Med Oncol. 30:3612013. View Article : Google Scholar : PubMed/NCBI

5 

Okusaka T, Ikeda M, Fukutomi A, Ioka T, Furuse J, Ohkawa S, Isayama H and Boku N: Phase II study of FOLFIRINOX for chemotherapy-naïve Japanese patients with metastatic pancreatic cancer. Cancer Sci. 105:1321–1326. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Lee KA, Kang HW, Ahn JH, Suk HJ and Kim H: Dysarthria induced by irinotecan in a patient with colorectal cancer. Am J Health Syst Pharm. 70:1140–1143. 2013. View Article : Google Scholar : PubMed/NCBI

7 

SevillaGarcia I, Rueda A and Alba E: Irinotecan-induced central nervous system toxicity: a case report. J Natl Cancer Inst. 91:6471999. View Article : Google Scholar

8 

Baz DV, Bofill JS and Nogueira JA: Irinotecan-induced dysarthria. J Natl Cancer Inst. 93:1419–1420. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Ceccaldi B, Kara F, MommejaMarin H, Bègue M, Saint Blancard P, Le Marec E and Hauteville D: Dysarthria during irinotecan administration. Rev Med Interne. 23:950–951. 2002.(In French). View Article : Google Scholar : PubMed/NCBI

10 

DeMarco S, Squilloni E, Vigna L, Bertagnolio MF and Sternberg CN: Irinotecan chemotherapy associated with transient dysarthria and aphasia. Ann Oncol. 15:1147–1148. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Hamberg P, Donders RC and Ten Bokkel Huinink D: Central nervous system toxicity induced by irinotecan. J Natl Cancer Inst. 98:2192006. View Article : Google Scholar : PubMed/NCBI

12 

Gomez JA, Sanchez I and Ramirez JA: Irinotecan-induced dysarthria: an insight into its pathogenesis? Gastrointest Cancer Res. 2:209–210. 2008.PubMed/NCBI

13 

Dressel AJ, van der Mijn JC, Aalders IJ, Rinkel RN and van der Vliet HJ: Irinotecan-induced dysarthria. Case Rep Oncol. 5:47–51. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Harel M, Hyatt JL, Brumshtein B, Morton CL, Yoon KJ, Wadkins RM, Silman I, Sussman JL and Potter PM: The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action. Mol Pharmacol. 67:1874–1881. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Haxhiu MA, Mitra J, van Lunteren E, Bruce EN and Cherniack NS: Hypoglossal and phrenic responses to cholinergic agents applied to ventral medullary surface. Am J Physiol. 247:R939–R944. 1984.PubMed/NCBI

16 

Cortes R, Probst A and Palacios JM: Quantitative light microscopic autoradiographic localization of cholinergic muscarinic receptors in the human brain: brainstem. Neuroscience. 12:1003–1026. 1984. View Article : Google Scholar : PubMed/NCBI

17 

Falcone A, Ricci S, Brunetti I, Pfanner E, Allegrini G, Barbara C, Crinò L, Benedetti G, Evangelista W, Fanchini L, et al: Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: The Gruppo Oncologico Nord Ovest. J Clin Oncol. 25:1670–1676. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Souglakos J, Androulakis N, Syrigos K, Polyzos A, Ziras N, Athanasiadis A, Kakolyris S, Tsousis S, Kouroussis Ch, Vamvakas L, et al: FOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin and irinotecan) vs. FOLFIRI (folinic acid, 5-fluorouracil and irinotecan) as first-line treatment in metastatic colorectal cancer (MCC): a multicenter randomized phase III trial from the Hellenic oncology research group (HORG). Br J Cancer. 94:798–805. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Masi G, Loupakis F, Salvatore L, Fornaro L, Cremolini C, Cupini S, Ciarlo A, Del Monte F, Cortesi E, Amoroso D, et al: Bevacizumab with FOLFOXIRI (irinotecan, oxaliplatin, fluorouracil and folinate) as first-line treatment for metastatic colorectal cancer: a phase 2 trial. Lancet Oncol. 11:845–852. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Park SB, Lin CS, Krishnan AV, Goldstein D, Friedlander ML and Kiernan MC: Oxaliplatin-induced neurotoxicity: Changes in axonal excitability precede development of neuropathy. Brain. 132:2712–2723. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Matsuoka A, Maeda O, Inada‑Inoue M, Ohno E, Hirooka Y, Yokoyama Y, Fujii T, Nagino M, Goto H, Ando Y, Ando Y, et al: FOLFIRINOX‑induced reversible dysarthria: A case report and review of previous cases. Oncol Lett 10: 2662-2664, 2015.
APA
Matsuoka, A., Maeda, O., Inada‑Inoue, M., Ohno, E., Hirooka, Y., Yokoyama, Y. ... Ando, Y. (2015). FOLFIRINOX‑induced reversible dysarthria: A case report and review of previous cases. Oncology Letters, 10, 2662-2664. https://doi.org/10.3892/ol.2015.3591
MLA
Matsuoka, A., Maeda, O., Inada‑Inoue, M., Ohno, E., Hirooka, Y., Yokoyama, Y., Fujii, T., Nagino, M., Goto, H., Ando, Y."FOLFIRINOX‑induced reversible dysarthria: A case report and review of previous cases". Oncology Letters 10.4 (2015): 2662-2664.
Chicago
Matsuoka, A., Maeda, O., Inada‑Inoue, M., Ohno, E., Hirooka, Y., Yokoyama, Y., Fujii, T., Nagino, M., Goto, H., Ando, Y."FOLFIRINOX‑induced reversible dysarthria: A case report and review of previous cases". Oncology Letters 10, no. 4 (2015): 2662-2664. https://doi.org/10.3892/ol.2015.3591
Copy and paste a formatted citation
x
Spandidos Publications style
Matsuoka A, Maeda O, Inada‑Inoue M, Ohno E, Hirooka Y, Yokoyama Y, Fujii T, Nagino M, Goto H, Ando Y, Ando Y, et al: FOLFIRINOX‑induced reversible dysarthria: A case report and review of previous cases. Oncol Lett 10: 2662-2664, 2015.
APA
Matsuoka, A., Maeda, O., Inada‑Inoue, M., Ohno, E., Hirooka, Y., Yokoyama, Y. ... Ando, Y. (2015). FOLFIRINOX‑induced reversible dysarthria: A case report and review of previous cases. Oncology Letters, 10, 2662-2664. https://doi.org/10.3892/ol.2015.3591
MLA
Matsuoka, A., Maeda, O., Inada‑Inoue, M., Ohno, E., Hirooka, Y., Yokoyama, Y., Fujii, T., Nagino, M., Goto, H., Ando, Y."FOLFIRINOX‑induced reversible dysarthria: A case report and review of previous cases". Oncology Letters 10.4 (2015): 2662-2664.
Chicago
Matsuoka, A., Maeda, O., Inada‑Inoue, M., Ohno, E., Hirooka, Y., Yokoyama, Y., Fujii, T., Nagino, M., Goto, H., Ando, Y."FOLFIRINOX‑induced reversible dysarthria: A case report and review of previous cases". Oncology Letters 10, no. 4 (2015): 2662-2664. https://doi.org/10.3892/ol.2015.3591
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team