Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2015 Volume 10 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2015 Volume 10 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Primary extragonadal germ cell tumor: A case report on prostate seminoma

  • Authors:
    • Wei Zheng
    • Lina Wang
    • Deyong Yang
    • Kun Fang
    • Xiaochi Chen
    • Xuejian Wang
    • Xiancheng Li
    • Ziyao Li
    • Xishuang Song
    • Jianbo Wang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China
  • Pages: 2323-2326
    |
    Published online on: August 11, 2015
       https://doi.org/10.3892/ol.2015.3592
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Primary extragonadal germ cell tumors are rare, and 60% of such cases are seminomas. While the tumors can occur in the mediastinum, thymus, retroperitoneal organs and pineal gland, seminoma originating in the prostate tissue is extremely rare. The present study reports the case of a 54‑year‑old male with prostate seminoma. The patient was followed up at the First Affiliated Hospital of Dalian Medical University (Dalian, Liaoning, China) from 2001 onwards. The patient received chemotherapy with cyclophosphamide following total resection of the pelvic organs, pelvic lymph node dissection, continent detenial cecum‑ascending colic bladder and orchidectomy. The patient experienced considerable post‑operative quality of life for >10 years and the disease did not reappear. The study indicated that extragonadal seminoma is sensitive to chemotherapy, and that radical surgery and post‑operative adjuvant chemotherapy with cyclophosphamide is a reasonable and feasible treatment method.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Bokemeyer C, Nichols CR, Droz JP, Schmoll HJ, Horwich A, Gerl A, Fossa SD, Beyer J, Pont J, Kanz L, et al: Extragonadal germ cell tumors of the mediastinum and retroperitoneum: results from an international analysis. J Clin Oncol. 20:1864–1873. 2002. View Article : Google Scholar : PubMed/NCBI

2 

KragJacobsen G, Barlebo H, Olsen J, et al: Testicular germ cell tumours in Denmark 1976–1980. Pathology of 1058 consecutive cases. Acta Radiol Oncol. 23:239–247. 1984. View Article : Google Scholar : PubMed/NCBI

3 

Raghavan D: Testicular cancer: Maintaining the high cure rate. Oncology (Williston Park). 17:218–228; discussion, 228–229. 2003.PubMed/NCBI

4 

Majewski W, Majewski S, Maciejewski A, et al: Adverse effects after radiotherapy for early stage (I, IIa, IIb) seminoma. Radiother Oncol. 76:257–263. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Hashimoto T, Ohori M, Sakamoto N, Matsubayashi J, Izumi M and Tachibana M: Primary seminoma of the prostate. Int J Urol. 16:967–970. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Albany C and Einhorn LH: Extragonadal germ cell tumors: Clinical presentation and management. Curr Opin Oncol. 25:261–265. 2013.PubMed/NCBI

7 

Stein ME, Charas T, Drumea K, Sabo E and Ben-Yosef R: Spermatocytic variant of classic seminoma: A report of five cases and a brief review of the literature. Rambam Maimonides Med J. 5:e00212014. View Article : Google Scholar : PubMed/NCBI

8 

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ: Cancer statistics, 2008. CA Cancer J Clin. 58:71–96. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Peters JA, Beckjord EB, Banda Ryan DR, Carr AG, Vadaparampil ST, Loud JT, Korde L and Greene MH: Testicular cancer and genetics knowledge among familial testicular cancer family members. J Genet Couns. 17:351–364. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Utz DC and Buscemi MF: Extragonadal testicular tumors. J Urol. 105:271–274. 1971.PubMed/NCBI

11 

Dueland S, Stenwig AE, Heilo A, Høie J, Ous S and Fosså SD: Treatment and outcome of patients with extragonadal germ cell tumours-the Norwegian Radium Hospital's experience 1979–94. Br J Cancer. 77:329–335. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Wallner LP, Frencher SK, Hsu JW, Chao CR, Nichol MB, Loo RK and Jacobsen SJ: Changes in serum prostate-specific antigen levels and the identification of prostate cancer in a large managed care population. BJU Int. 111:1245–1252. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Alapetite C, Brisse H, Patte C, et al: Pattern of relapse and outcome of non-metastatic germinoma patients treated with chemotherapy and limited field radiation: The SFOP experience. Neuro Oncol. 12:1318–1325. 2010.PubMed/NCBI

14 

Gerl A, Clemm C, Lamerz R and Wilmanns W: Cisplatin-based chemotherapy of primary extragonadal germ cell tumors. A single institution experience. Cancer. 77:526–532. 1996. View Article : Google Scholar : PubMed/NCBI

15 

Powles T, Robinson D, Shamash J, Moller H, Tranter N and Oliver T: The long-term risks of adjuvant carboplatin treatment for stage I seminoma of the testis. Ann Oncol. 19:443–447. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Horwich A: Stage I seminoma and carboplatin risks. Ann Oncol. 19:407–408. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Waxman DJ: Glutathione S-transferases: role in alkylating agent resistance and possible target for modulation chemotherapy - a review. Cancer Res. 50:6449–6454. 1990.PubMed/NCBI

18 

Shulman LN: The biology of alkylating-agent cellular injury. Hematol Oncol Clin North Am. 7:325–335. 1993.PubMed/NCBI

19 

Choi YJ, Ok DW, Kwon DN, Chung JI, Kim HC, Yeo SM, Kim T, Seo HG and Kim JH: Murine male germ cell apoptosis induced by busulfan treatment correlates with loss of c-kit-expression in a Fas/FasL- and p53-independent manner. FEBS Lett. 575:41–51. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Schimenti KJ, Hanneman WH and Schimenti JC: Evidence for cyclophosphamide-induced gene conversion and mutation in mouse germ cells. Toxicol Appl Pharmacol. 147:343–350. 1997. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zheng W, Wang L, Yang D, Fang K, Chen X, Wang X, Li X, Li Z, Song X, Wang J, Wang J, et al: Primary extragonadal germ cell tumor: A case report on prostate seminoma. Oncol Lett 10: 2323-2326, 2015.
APA
Zheng, W., Wang, L., Yang, D., Fang, K., Chen, X., Wang, X. ... Wang, J. (2015). Primary extragonadal germ cell tumor: A case report on prostate seminoma. Oncology Letters, 10, 2323-2326. https://doi.org/10.3892/ol.2015.3592
MLA
Zheng, W., Wang, L., Yang, D., Fang, K., Chen, X., Wang, X., Li, X., Li, Z., Song, X., Wang, J."Primary extragonadal germ cell tumor: A case report on prostate seminoma". Oncology Letters 10.4 (2015): 2323-2326.
Chicago
Zheng, W., Wang, L., Yang, D., Fang, K., Chen, X., Wang, X., Li, X., Li, Z., Song, X., Wang, J."Primary extragonadal germ cell tumor: A case report on prostate seminoma". Oncology Letters 10, no. 4 (2015): 2323-2326. https://doi.org/10.3892/ol.2015.3592
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng W, Wang L, Yang D, Fang K, Chen X, Wang X, Li X, Li Z, Song X, Wang J, Wang J, et al: Primary extragonadal germ cell tumor: A case report on prostate seminoma. Oncol Lett 10: 2323-2326, 2015.
APA
Zheng, W., Wang, L., Yang, D., Fang, K., Chen, X., Wang, X. ... Wang, J. (2015). Primary extragonadal germ cell tumor: A case report on prostate seminoma. Oncology Letters, 10, 2323-2326. https://doi.org/10.3892/ol.2015.3592
MLA
Zheng, W., Wang, L., Yang, D., Fang, K., Chen, X., Wang, X., Li, X., Li, Z., Song, X., Wang, J."Primary extragonadal germ cell tumor: A case report on prostate seminoma". Oncology Letters 10.4 (2015): 2323-2326.
Chicago
Zheng, W., Wang, L., Yang, D., Fang, K., Chen, X., Wang, X., Li, X., Li, Z., Song, X., Wang, J."Primary extragonadal germ cell tumor: A case report on prostate seminoma". Oncology Letters 10, no. 4 (2015): 2323-2326. https://doi.org/10.3892/ol.2015.3592
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team