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Article

Primary neuroendocrine tumors of the ear, nose and throat: A report of three cases and a review of the literature

  • Authors:
    • Rachad Mhawej
    • Chadi Farah
    • Amine Haddad
    • Bassam Tabchy
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology‑Head and Neck Surgery, Hotel Dieu De France Hospital, Saint Joseph University, School of Medicine, Beirut 166830, Lebanon
  • Pages: 2533-2536
    |
    Published online on: August 13, 2015
       https://doi.org/10.3892/ol.2015.3606
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Abstract

The aim of the present study was to review all cases of neuroendocrine tumors of the ear, nose and throat in a tertiary care center, as well as the data published in the literature. The study presents all the cases of neuroendocrine tumors (NETs) in the Hotel Dieu De France Hospital (Beirut, Lebanon) between January 2004 and January 2014. The data reported in the English and French literature is also reviewed with regard to the typical clinical presentation and management of these tumors. Three cases of NETs presented to the Department of Otolaryngology-Head and Neck Surgery during the study period. One case was of an atypical carcinoid (AC) tumor of the larynx, one case was of a typical carcinoid tumor in the middle ear and the third case was, to the best of our knowledge, the first reported case of an AC tumor of the nasopharynx. Overall, NETs are rare in the head and neck. The clinical presentation can mimic any other tumor in the same localization in the absence of a carcinoid syndrome. Management of these tumors remains controversial, but a complete excision of the tumor is crucial, followed by possible adjuvant treatment.
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1 

Bapat U, Mackinnon N and Spencer MG: Carcinoid tumours of the larynx. Eur Arch Otorhinolaryngol. 262:194–197. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Barnes L, Eveson J, Reichart P and Sidransky DE: Neuroendocrine tumoursWorld Health Organization Classification of Tumours: Pathology and Genetics of Head and Neck Tumours. IARC Press; Lyon: pp. 135–139. 2005

3 

Klimstra DS, Modlin IR, Coppola D, Lloyd RV and Suster S: The pathologic classification of neuroendocrine tumors: A review of nomenclature, grading and staging systems. Pancreas. 39:707–712. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Meacham R, Matrka L, Ozer E, Ozer HG, Wakely P and Shah M: Neuroendocrine carcinoma of the head and neck: A 20-year case series. Ear Nose Throat J. 91:E20–E24. 2012.PubMed/NCBI

5 

Kunz PL: Carcinoid and neuroendocrine Tumors: Building on success. J Clin Oncol. 33:1855–1863. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Kao H-L, Chang W-C, Li W-Y, Chia-Heng Li A and Fen-Yau Li A: Head and neck large cell neuroendocrine carcinoma should be separated from atypical carcinoid on the basis of different clinical features, overall survival and pathogenesis. Am J Surg Pathol. 36:185–192. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Weinreb I and Perez-Ordoñez B: Non-small cell neuroendocrine carcinoma of the sinonasal tract and nasopharynx. Report of 2 cases and review of the literature. Head Neck Pathol. 1:21–26. 2007. View Article : Google Scholar : PubMed/NCBI

8 

LewisJS Jr, Ferlito A, Gnepp DR, Rinaldo A, Devaney KO, Silver CE and Travis WD: International Head and Neck Scientific Group: Terminology and classification of neuroendocrine neoplasms of the larynx. Laryngoscope. 121:1187–1193. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Ferlito A and Rinaldo A: The spectrum of endocrinocarcinomas of the larynx. Oral Oncol. 41:878–883. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Ferlito A, Devaney KO and Rinaldo A: Neuroendocrine neoplasms of the larynx: Advances in identification, understanding and management. Oral Oncol. 42:770–788. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Tabuchi K, Aoyagi Y, Uemaetomari I, Tobita T, Wada T, Inadome Y, Noguchi M and Hara A: Carcinoid tumours of the middle ear. J Otolaryngol Neck Surg. 38:E91–E94. 2009.

12 

Bittencourt AG, Tsuji RK, Cabral F Junior, Pereira LV, Fonseca AC, Alves V and Bento RF: Middle ear adenoma with neuroendocrine differentiation: Relate of two cases and literature review. Int Arch Otorhinolaryngol. 17:340–343. 2013.PubMed/NCBI

13 

Ferlito A, Silver CE, Bradford CR and Rinaldo A: Neuroendocrine neoplasms of the larynx: An overview. Head Neck. 31:1634–1646. 2009. View Article : Google Scholar : PubMed/NCBI

14 

van der Laan TP, Plaat BE, van der Laan BF and Halmos GB: Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: A meta analysis of 436 reported cases. Head Neck. 37:707–715. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Myssiorek D, Rinaldo A, Barnes L and Ferlito A: Laryngeal paraganglioma: An updated critical review. Acta Otolaryngol. 124:995–999. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Baig S, Patil N and Considine N: Carcinoid tumour of the middle ear. J Coll Physicians Surg Pak. 22:604–606. 2012.PubMed/NCBI

17 

Ramsey MJ, Nadol JB Jr..Pilch BZ and McKenna MJ: Carcinoid tumor of the middle ear: Clinical features, recurrences and metastases. Laryngoscope. 115:1660–1666. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Krouse JH, Nadol JB and Goodman ML: Carcinoid tumors of the middle ear. Ann Otol Rhinol Laryngol. 99:547–552. 1990. View Article : Google Scholar : PubMed/NCBI

19 

Galm T and Turner N: Primary carcinoid tumour of nasal septum. J Laryngol Otol. 123:789–792. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Kanoh N, Nishimura Y, Nakamura M, Mori M and Uematsu K: Primary nasopharyngeal paraganglioma: A case report. Auris Nasus Larynx. 18:307–314. 1991. View Article : Google Scholar : PubMed/NCBI

21 

Li AL, Wehrli B and Rotenberg BW: Carcinoid tumour arising simultaneous to an inverted papilloma in the nasal cavity. J Otolaryngol Head Neck Surg. 39:E78–E82. 2010.PubMed/NCBI

22 

Vandist V, Deridder F, Waelput W, Parizel PM, Van de Heyning P and Van Laer C: A neuroendocrine tumour of the sphenoid sinus and nasopharynx: A case report. B-ENT. 6:147–151. 2010.PubMed/NCBI

23 

Chu MW, Karakla DW, Silverberg M and Han JK: Primary carcinoid tumor of the frontal sinus: A case report. Ear Nose Throat J. 89:E13–E16. 2010.PubMed/NCBI

24 

Furuta A, Kudo M, Kanai K, Ohki S and Suzaki H: Typical carcinoid tumor arising in the nose and paranasal sinuses-case report. Auris Nasus Larynx. 37:381–385. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Lee DH, Cho HH and Cho YB: Typical carcinoid tumor of the nasal cavity. Auris Nasus Larynx. 34:537–539. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Mhawej R, Farah C, Haddad A and Tabchy B: Primary neuroendocrine tumors of the ear, nose and throat: A report of three cases and a review of the literature. Oncol Lett 10: 2533-2536, 2015.
APA
Mhawej, R., Farah, C., Haddad, A., & Tabchy, B. (2015). Primary neuroendocrine tumors of the ear, nose and throat: A report of three cases and a review of the literature. Oncology Letters, 10, 2533-2536. https://doi.org/10.3892/ol.2015.3606
MLA
Mhawej, R., Farah, C., Haddad, A., Tabchy, B."Primary neuroendocrine tumors of the ear, nose and throat: A report of three cases and a review of the literature". Oncology Letters 10.4 (2015): 2533-2536.
Chicago
Mhawej, R., Farah, C., Haddad, A., Tabchy, B."Primary neuroendocrine tumors of the ear, nose and throat: A report of three cases and a review of the literature". Oncology Letters 10, no. 4 (2015): 2533-2536. https://doi.org/10.3892/ol.2015.3606
Copy and paste a formatted citation
x
Spandidos Publications style
Mhawej R, Farah C, Haddad A and Tabchy B: Primary neuroendocrine tumors of the ear, nose and throat: A report of three cases and a review of the literature. Oncol Lett 10: 2533-2536, 2015.
APA
Mhawej, R., Farah, C., Haddad, A., & Tabchy, B. (2015). Primary neuroendocrine tumors of the ear, nose and throat: A report of three cases and a review of the literature. Oncology Letters, 10, 2533-2536. https://doi.org/10.3892/ol.2015.3606
MLA
Mhawej, R., Farah, C., Haddad, A., Tabchy, B."Primary neuroendocrine tumors of the ear, nose and throat: A report of three cases and a review of the literature". Oncology Letters 10.4 (2015): 2533-2536.
Chicago
Mhawej, R., Farah, C., Haddad, A., Tabchy, B."Primary neuroendocrine tumors of the ear, nose and throat: A report of three cases and a review of the literature". Oncology Letters 10, no. 4 (2015): 2533-2536. https://doi.org/10.3892/ol.2015.3606
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