Open Access

Comparative genomic hybridization analysis of invasive ductal breast carcinomas in the Chinese population

  • Authors:
    • Jianwei Zhang
    • Hongyan Zhang
    • Xin Xu
    • Mingrong Wang
    • Zhonghe Yu
  • View Affiliations

  • Published online on: August 14, 2015     https://doi.org/10.3892/ol.2015.3608
  • Pages: 2100-2106
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer is the most common malignancy in Chinese women. The aim of the present study was to investigate the genetic alterations that occur in breast cancer cells in Chinese women. Comparative genomic hybridization (CGH) analysis was performed on 34 tumors obtained from patients with primary invasive ductal breast carcinoma (IDC). Recurrent genetic alterations in breast cancer include gains on chromosomes 1q (59%), 16p (50%), 17q (44%), 8q (38%), 11q (32%), 20q (32%), 1p (24%), 20p (24%), 19q (21%) and 19p (18%). Losses are common on chromosomes 6q (15%), 8p (12%), 18 (12%), 4q (9%), X (9%) and 17p (9%). In the present study, high‑level amplifications were observed on chromosomes 1q32, 8p, 11q13, 17q and 20q. Overall, the chromosomal DNA gains observed were consistent with the changes reported in Caucasian populations. However, the incidence of chromosomal DNA loss was lower in the present study compared with the incidence reported in the literature. The present results demonstrate the pattern of chromosomal imbalances in the invasive ductal breast carcinomas of Chinese females.
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October-2015
Volume 10 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang J, Zhang H, Xu X, Wang M and Yu Z: Comparative genomic hybridization analysis of invasive ductal breast carcinomas in the Chinese population. Oncol Lett 10: 2100-2106, 2015.
APA
Zhang, J., Zhang, H., Xu, X., Wang, M., & Yu, Z. (2015). Comparative genomic hybridization analysis of invasive ductal breast carcinomas in the Chinese population. Oncology Letters, 10, 2100-2106. https://doi.org/10.3892/ol.2015.3608
MLA
Zhang, J., Zhang, H., Xu, X., Wang, M., Yu, Z."Comparative genomic hybridization analysis of invasive ductal breast carcinomas in the Chinese population". Oncology Letters 10.4 (2015): 2100-2106.
Chicago
Zhang, J., Zhang, H., Xu, X., Wang, M., Yu, Z."Comparative genomic hybridization analysis of invasive ductal breast carcinomas in the Chinese population". Oncology Letters 10, no. 4 (2015): 2100-2106. https://doi.org/10.3892/ol.2015.3608