Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2015 Volume 10 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2015 Volume 10 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients

  • Authors:
    • He Li
    • Xuefei Wang
    • Zhaoqing Tang
    • Fenglin Liu
    • Weidong Chen
    • Yong Fang
    • Cong Wang
    • Kuntang Shen
    • Jing Qin
    • Zhenbin Shen
    • Yihong Sun
    • Xinyu Qin
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2107-2117
    |
    Published online on: August 14, 2015
       https://doi.org/10.3892/ol.2015.3609
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Fatty acid synthase (FAS) and human epidermal growth factor receptor 2 (HER2) are overexpressed in gastric cancer (GC), and certain interactions have been found between FAS and HER2. A total of 94 patients were enrolled in the present study, each of whom underwent a D2 radical surgery in Zhongshan Hospital affiliated with Fudan University (Shanghai, China) between 2000 and 2005. The expression of FAS and HER2 was assessed by immunohistochemistry analysis of tissue microarrays generated from GC and non‑tumor tissues. All data were analyzed by GraphPad Prism 5.0 to investigate the association between FAS and HER2 and to detect the potential association with prognosis. FAS (P<0.0001) and membranous HER2 (mHER2; P=0.0021) were overexpressed in the GC tissues, and a bidirectional and strong correlation was demonstrated between FAS and mHER2 in the tumor tissues. The expression of cytoplasmic HER2 (cHER2) was significantly lower in the GC tissues compared with the non‑tumor tissues (P=0.0005), and cHER2 was expressed at a higher level in tumors that had better differentiation compared with poorly‑differentiated tissues (P=0.0503). Patients with a concordant expression pattern of FAS and mHER2 showed a significantly poorer prognosis than the non‑concordant group (P=0.0096; hazards ratio, 3.2801; 95% confidence interval, 1.5781‑6.8176). GC tissues significantly overexpress FAS and mHER2 and the expression of these two markers is associated. Patients with a concordant expression of FAS and mHER2 are more likely to suffer a poor prognosis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Devesa SS, Blot WJ and Fraumeni JF Jr.: Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer. 83:2049–2053. 1998. View Article : Google Scholar : PubMed/NCBI

2 

Kuhajda FP: Fatty acid synthase and cancer: New application of an old pathway. Cancer Res. 66:5977–5980. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Notarnicola M, Tutino V, Calvani M, et al: Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA):A phase3, open-label, randomised controlled trial. Lancet. 376:687–697. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Ito T, Sako K, Maekawa H, et al: Elevated levels of serum fatty acid synthase in patients with gastric carcinoma. Oncol Lett. 7:616–620. 2014.PubMed/NCBI

5 

Menendez JA and Lupu R: Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer. 7:763–777. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Weiss L, Hoffmann GE, Schreiber R, et al: Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase. Biol Chem Hoppe Seyler. 367:905–912. 1986. View Article : Google Scholar : PubMed/NCBI

7 

Wagle S, Bui A, Ballard Pl, et al: Hormonal regulation and cellular localization of fatty acid synthase in human fetal lung. Am J Physiol. 227:L381–L390. 1999.

8 

Kusakabe T, Maeda M, Hoshi N, et al: Fatty acid synthase is expressed mainly in adult hormone-sensitive cells or cells with high lipid metabolism and in proliferating fetal cells. J Histochem Cytochem. 48:613–622. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Pizer ES, Kurman RJ, Pasternack GR and Kuhjada FP: Expression of fatty acid synthase is closely linked to prolieration and stromal decidualization in cycling endometrium. Int J Gynecol Pathol. 16:45–51. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Kuhajada FP: Fatty acid synathase and cancer: New application of an old pathway. Cancer Res. 66:5977–5980. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Abramson HN: The lipogenesis pathway as a cancer target. J Med Chem. 54:5615–5638. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Tischler V, Fritzsche FR, Gerhardt J, et al: Comparison of the diagnostic value of fatty acid synthase (FASN) with alpha-methylacyl-CoA racemase (AMACR) as prostatic cancer tissue marker. Histopathology. 56:811–815. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Nguyen PL, Ma J, Chavarro JE, et al: Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival. J Clin Oncol. 28:3958–3964. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Heo CK, Woo MK, Yu DY, et al: Identification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC. Int J Oncol. 36:1453–1459. 2010.PubMed/NCBI

15 

Ishimura N, Amano Y, SanchezSiles AA, et al: Fatty acid synthase expression in Barrett's esophagus: Implications for carcinogenesis. J Clin Gastroenterol. 45:665–672. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Furuta E, Pai SK, Zhan R, et al: Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1. Cancer Res. 68:1003–1011. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Calvisi DF, Wang C, Ho C, et al: Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Gastroenterology. 140:1071–1083. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Kim K, Kim HY, Cho HK, Kim KH and Cheong J: The SDF-1alpha/CXCR4 axis induces the expression of fatty acid synthase via sterol regulatory element-binding protein-1 activation in cancer cells. Carcinogenesis. 31:679–686. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Yan B, Yau EX, Bte Omar SS, et al: A study of HER2 gene amplification and protein expression in gastric cancer. J Clin Pathol. 63:839–842. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Grunt TW, Wagner R, Grusch M, et al: Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells. Biochem Biophys Res Commun. 385:454–459. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Oliveras G, Blancafort A, Urruticoechea A, et al: Novel anti-fatty acid synthase compounds with anti-cancer activity in HER2+ breast cancer. Ann N Y Acad Sci. 1210:86–92. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Jin Q, Yuan LX, Boulbes D, et al: Fatty acid synthase phosphorylation: A novel therapeutic target in HER2-overexpressing breast cancer cells. Breast Cancer Res. 12:R962010. View Article : Google Scholar : PubMed/NCBI

23 

Silva SD, Perez DE, Alves FA, et al: ErbB2 and fatty acid synthase (FAS) expression in 102 squamous cell carcinomas of the tongue: Correlation with clinical outcomes. Oral Oncol. 44:484–490. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Rice TW, Blackstone EH and Rusch VW: 7th edition of the AJCC Cancer Staging Manual: Esophagus and Esophagogastric Junction. Ann Surg Oncol. 17:1721–1724. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Washington K: 7th edition of the AJCC Cancer Staging Manual: Stomach. Ann Surg Oncol. 17:3077–3079. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Weiss SW: Franz M. Enzinger: His life and work. Adv Anat Pathol. 13:109–113. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Kindblom LG: Lipomatous tumours - how we have reached our present views, what controversies remain and why we still face diagnostic problems: A tribute to Dr Franz Enzinger. Adv Anat Pathol. 13:279–285. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Ajana JA, Bathel JS, BekaiiSaab T, et al: Gastric cancer. J Natl Compr Canc Netw. 8:378–409. 2010.PubMed/NCBI

29 

Vandhana S, Deepa PR, Jayanthi U, Biswas J and Krishnakumar S: Clinico-pathological correlations of fatty acid synthase expression in retinoblastoma: An Indian cohort study. Exp Mol Pathol. 90:29–37. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Chung KY, Shia J, Kemeny NE, et al: Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol. 23:1803–1810. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Shah MA, Jhawer M, Ilson DH, et al: Phase II study of modified docetaxel, cisplatin, and fluororacil with bevacizymab in patients with metastatic gastroesophageal adenocarcinoma. J Clin Oncol. 23:1803–1810. 2005.PubMed/NCBI

32 

Shah MA, Power DG, Kindler HL, et al: A multicenter, phase II study of bortezomib (PS-341) in patients with unresectable or metastatic gastric and gastroesophageal junction adenomcarcinoma. Invest New Drugs. 29:1475–1481. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Doi T, Muro K, Boku N, et al: Multicenter phase II study of everolimus in patients with previously treated metastatic gastric cancer. J Clin Oncol. 28:1904–1910. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Gabrielson EW, Pinn ML, Testa JR and Kuhajda FP: Increased fatty acid synthase is a therapeutic target in mesothelioma. Clin Cancer Res. 7:153–157. 2001.PubMed/NCBI

35 

Orita H, Coulter J, Tully E, et al: High levels of fatty acid synthase expression in esophageal cancers represent a potential target for therapy. Cancer Biol Ther. 10:549–554. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Kearney KE, Pretlow TG and Pretlow TP: Increased expression of fatty acid synthase in human aberrant crypt foci: Possible target for colorectal cancer prevention. Int J Cancer. 125:249–252. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Visca P, Sebastiani V, Botti C, et al: Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma. Anticancer Res. 24:4169–4173. 2004.PubMed/NCBI

38 

Kapur P, Rakheja D, Roy LC and Hoang MP: Fatty acid synthase expression in cutaneous melanocytic neoplasms. Mod Pathol. 18:1107–1112. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Kusakabe T, Nashimoto A, Honma K and Suzuki T: Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach. Histopathology. 40:71–79. 2002. View Article : Google Scholar : PubMed/NCBI

40 

Dowling S, Cox J and Cenedella RJ: Inhibition of fatty acid synthase by Orlistat accelerates gastric tumor cell apoptosis in culture and increases survival rates in gastric tumor bearing mice in vivo. Lipids. 44:489–498. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Allgayer H, Babic R, Gruetzner KU, Tarabichi A, Schildberg FW and Heiss MM: c-erbB-2 is of independent prognostic relevance in gastric cancer and is associated with the expression of tumor-associated protease systems. J Clin Oncol. 18:2201–2209. 2000.PubMed/NCBI

42 

Matsubara J, Yamada Y, Hirashima Y, et al: Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer. Clin Cancer Res. 14:3022–3029. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Grabsch H, Sivakumar S, Gray S, Gabbert HE and Müller W: HER2 expression in gastric cancer: Rare, heterogeneous and of no prognostic value - conclusions from 924 cases of two independent series. Cell Oncol. 32:57–65. 2010.PubMed/NCBI

44 

Kim KC, Koh YW, Chang HM, et al: Evaluation of HER2 protein expression in gastric carcinomas: Comparative analysis of 1,414 cases of whole-tissue sections and 595 cases of tissue microarrays. Ann Surg Oncol. 18:2833–2840. 2011. View Article : Google Scholar : PubMed/NCBI

45 

KumarSinha C, Ignatoski KW, Lippman ME, Ethier SP and Chinnaiyan AM: Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis. Cancer Res. 63:132–139. 2003.PubMed/NCBI

46 

VazquezMartin A, FernandezReal JM, OliverasFerraros C, et al: Fatty acid synthase activity regulates HER2 extracellular domain shedding into the circulation of HER2-positive metastatic breast cancer patients. Int J Oncol. 35:1369–1376. 2009.PubMed/NCBI

47 

VazquezMartin A, Colomer R, Brunet J, Lupu R and Menendez JA: Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells. Cell Prolif. 41:59–85. 2008. View Article : Google Scholar : PubMed/NCBI

48 

Silva SD, Cunha IW, Rangel AL, et al: Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes. Virchows Arch. 453:57–67. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Menendez JA, Papadimitropoulou A, Vellon L and Lupu R: A genomic explanation connecting ‘Mediterranean diet’, olive oil and cancer: Oleic acid, the main monounsaturated fatty acid of olive oil, induces formation of inhibitory ‘PEA3 transcription factor-PEA3 DNA binding site’ complexes at the Her-2/neu (erbB-2) oncogene promoter in breast, ovarian and stomach cancer cells. Eur J Cancer. 42:2425–2432. 2006. View Article : Google Scholar : PubMed/NCBI

50 

Lin JT, Wu MS, Shun CT, Lee WJ, Sheu JC and Wang TH: Occurrence of microsatellite instability in gastric carcinoma is associated with enhanced expression of erbB-2 oncoprotein. Cancer Res. 55:1428–1430. 1995.PubMed/NCBI

51 

Wu MS, Shun CT, Wang HP, et al: Genetic alterations in gastric cancer: Relation to histological subtypes, tumor stage, and Helicobacter pylori infection. Gastroenterology. 112:1457–1465. 1997. View Article : Google Scholar : PubMed/NCBI

52 

Polkowski W, van Sandick JW, Offerhaus GJ, et al: Prognostic value of Laurén classification and c-erbB-2 oncogene overexpression in adenocarcinoma of the esophagus and gastroesophageal junction. Ann Surg Oncol. 6:290–297. 1999. View Article : Google Scholar : PubMed/NCBI

53 

Lemoine NR, Jain S, Silvestre F, et al: Amplification and overexpression of the EGF receptor and c-erbB-2 proto-oncogenes in human stomach cancer. Br J Cancer. 64:79–83. 1991. View Article : Google Scholar : PubMed/NCBI

54 

Tanner M, Hollmén M, Junttila TT, et al: Amplification of HER-2 in gastric carcinoma: Association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab. Ann Oncol. 16:273–278. 2005. View Article : Google Scholar : PubMed/NCBI

55 

Alli PM, Pinn ML, Jaffee EM, McFadden JM and Kuhajda FP: Fatty acid synthase inhibitors are chemopreventative for mammary cancer in neu-N transgenic mice. Oncogene. 24:39–46. 2005. View Article : Google Scholar : PubMed/NCBI

56 

Gravalos C and Jimeno A: HER2 in gastric cancer: A new prognostic factor and a novel therapeutic target. Ann Oncol. 19:1523–1529. 2008. View Article : Google Scholar : PubMed/NCBI

57 

DeVita F, Giuliani F, Silvestris N, Catalano G, Ciardiello F and Orditura M: Human epidermal growth factor receptor 2 (HER2) in gastric cancer: A new therapeutic target. Cancer Treat Rev. 36 Suppl 3:S11–S15. 2010. View Article : Google Scholar

58 

Lee KE, Lee HJ, Kim YH, et al: Prognostic significance of p53, nm23, PCNA and c-erbB-2 in gastric cancer. Jpn J Clin Oncol. 33:173–179. 2003. View Article : Google Scholar : PubMed/NCBI

59 

Yu GZ, Chen Y and Wang JJ: Overexpression of Grb2/HER2 signaling in Chinese gastric cancer: Their relationship with clinicopathological parameters and prognostic significance. J Cancer Res Clin Oncol. 135:1331–1339. 2009. View Article : Google Scholar : PubMed/NCBI

60 

Park DI, Yun JW, Park JH, et al: HER-2/neu amplification is an independent prognostic factor in gastric cancer. Dig Dis Sci. 51:1371–1379. 2006. View Article : Google Scholar : PubMed/NCBI

61 

Begnami MD, Fukuda E, Fregnani JH, et al: Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome. J Clin Oncol. 29:3030–3036. 2011. View Article : Google Scholar : PubMed/NCBI

62 

Pauletti G, Godolphin W, Press MF and Slamon DJ: Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization. Oncogene. 13:63–72. 1996.PubMed/NCBI

63 

Hochwald SN, Kim S, Klimstra DS, Brennan MF and Karpeh MS: Analysis of 154 actual five-year survivors of gastric cancer. J Gastrointest Surg. 4:520–525. 2000. View Article : Google Scholar : PubMed/NCBI

64 

Takahiro T, Shinichi K and Toshimitsu S: Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas. Clin Cancer Res. 9:2204–2212. 2003.PubMed/NCBI

65 

Migita T, Ruiz S, Fornari A, et al: Fatty acid synthase: A metabolic enzyme and candidate oncogene in prostate cancer. J Natl Cancer Inst. 101:519–532. 2009. View Article : Google Scholar : PubMed/NCBI

66 

Lan KH, Lu CH and Yu D: Mechanisms of trastuzumab resistance and their clinical implications. Ann N Y Acad Sci. 1059:70–75. 2005. View Article : Google Scholar : PubMed/NCBI

67 

Nahta R, Yu D, Hung MC, Hortobagyi GN and Esteva FJ: Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol. 3:269–280. 2006. View Article : Google Scholar : PubMed/NCBI

68 

Nahta R and Esteva FJ: Herceptin: Mechanisms of action and resistance. Cancer Lett. 232:123–138. 2006. View Article : Google Scholar : PubMed/NCBI

69 

Hortobagyi GN: Trastuzumab in the treatment of breast cancer. N Engl J Med. 353:1734–1736. 2005. View Article : Google Scholar : PubMed/NCBI

70 

VazquezMartin A, Colomer R, Brunet J and Menendez JA: Pharmacological blockade of fatty acid synthase (FASN) reverses acquired autoresistance to trastuzumab (Herceptin by transcriptionally inhibiting ‘HER2 super-expression’ occurring in high-dose trastuzumab-conditioned SKBR3/Tzb100 breast cancer cells. Int J Oncol. 31:769–776. 2007.PubMed/NCBI

71 

Menendez JA, Vellon L and Lupu R: Targeting fatty acid synthase-driven lipid rafts: A novel strategy to overcome trastuzumab resistance in breast cancer cells. Med Hypotheses. 64:997–1001. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li H, Wang X, Tang Z, Liu F, Chen W, Fang Y, Wang C, Shen K, Qin J, Shen Z, Shen Z, et al: A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients. Oncol Lett 10: 2107-2117, 2015.
APA
Li, H., Wang, X., Tang, Z., Liu, F., Chen, W., Fang, Y. ... Qin, X. (2015). A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients. Oncology Letters, 10, 2107-2117. https://doi.org/10.3892/ol.2015.3609
MLA
Li, H., Wang, X., Tang, Z., Liu, F., Chen, W., Fang, Y., Wang, C., Shen, K., Qin, J., Shen, Z., Sun, Y., Qin, X."A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients". Oncology Letters 10.4 (2015): 2107-2117.
Chicago
Li, H., Wang, X., Tang, Z., Liu, F., Chen, W., Fang, Y., Wang, C., Shen, K., Qin, J., Shen, Z., Sun, Y., Qin, X."A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients". Oncology Letters 10, no. 4 (2015): 2107-2117. https://doi.org/10.3892/ol.2015.3609
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Wang X, Tang Z, Liu F, Chen W, Fang Y, Wang C, Shen K, Qin J, Shen Z, Shen Z, et al: A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients. Oncol Lett 10: 2107-2117, 2015.
APA
Li, H., Wang, X., Tang, Z., Liu, F., Chen, W., Fang, Y. ... Qin, X. (2015). A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients. Oncology Letters, 10, 2107-2117. https://doi.org/10.3892/ol.2015.3609
MLA
Li, H., Wang, X., Tang, Z., Liu, F., Chen, W., Fang, Y., Wang, C., Shen, K., Qin, J., Shen, Z., Sun, Y., Qin, X."A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients". Oncology Letters 10.4 (2015): 2107-2117.
Chicago
Li, H., Wang, X., Tang, Z., Liu, F., Chen, W., Fang, Y., Wang, C., Shen, K., Qin, J., Shen, Z., Sun, Y., Qin, X."A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients". Oncology Letters 10, no. 4 (2015): 2107-2117. https://doi.org/10.3892/ol.2015.3609
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team