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Article

Mitochondrial reactive oxygen species and complex II levels are associated with the outcome of hepatocellular carcinoma

  • Authors:
    • Jianhua Wu
    • Fei Zhao
    • Yufei Zhao
    • Zhanjun Guo
  • View Affiliations / Copyright

    Affiliations: Experimental Animal Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
  • Pages: 2347-2350
    |
    Published online on: August 18, 2015
       https://doi.org/10.3892/ol.2015.3621
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Abstract

In the present study, two oxidative stress parameters, reactive oxygen species (ROS) and mitochondrial respiratory complex II, were evaluated in the mitochondria of hepatocellular carcinoma (HCC) cells to determine the association between these parameters and the carcinogenesis and clinical outcome of HCC. High levels of ROS and low levels of complex II were found to be associated with reduced post‑operative survival in HCC patients using the log‑rank test. Furthermore, multivariate analysis confirmed that the levels of ROS [relative risk (RR)=2.867; 95% confidence interval (CI), 1.062‑7.737; P=0.038] and complex II (RR=5.422; 95% CI, 1.273‑23.088; P=0.022) were independent predictors for the survival of patients with HCC. Therefore, the analysis of ROS and complex II levels may provide a useful research and therapeutic tool for the prediction of HCC prognosis and treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Wu J, Zhao F, Zhao Y and Guo Z: Mitochondrial reactive oxygen species and complex II levels are associated with the outcome of hepatocellular carcinoma. Oncol Lett 10: 2347-2350, 2015.
APA
Wu, J., Zhao, F., Zhao, Y., & Guo, Z. (2015). Mitochondrial reactive oxygen species and complex II levels are associated with the outcome of hepatocellular carcinoma. Oncology Letters, 10, 2347-2350. https://doi.org/10.3892/ol.2015.3621
MLA
Wu, J., Zhao, F., Zhao, Y., Guo, Z."Mitochondrial reactive oxygen species and complex II levels are associated with the outcome of hepatocellular carcinoma". Oncology Letters 10.4 (2015): 2347-2350.
Chicago
Wu, J., Zhao, F., Zhao, Y., Guo, Z."Mitochondrial reactive oxygen species and complex II levels are associated with the outcome of hepatocellular carcinoma". Oncology Letters 10, no. 4 (2015): 2347-2350. https://doi.org/10.3892/ol.2015.3621
Copy and paste a formatted citation
x
Spandidos Publications style
Wu J, Zhao F, Zhao Y and Guo Z: Mitochondrial reactive oxygen species and complex II levels are associated with the outcome of hepatocellular carcinoma. Oncol Lett 10: 2347-2350, 2015.
APA
Wu, J., Zhao, F., Zhao, Y., & Guo, Z. (2015). Mitochondrial reactive oxygen species and complex II levels are associated with the outcome of hepatocellular carcinoma. Oncology Letters, 10, 2347-2350. https://doi.org/10.3892/ol.2015.3621
MLA
Wu, J., Zhao, F., Zhao, Y., Guo, Z."Mitochondrial reactive oxygen species and complex II levels are associated with the outcome of hepatocellular carcinoma". Oncology Letters 10.4 (2015): 2347-2350.
Chicago
Wu, J., Zhao, F., Zhao, Y., Guo, Z."Mitochondrial reactive oxygen species and complex II levels are associated with the outcome of hepatocellular carcinoma". Oncology Letters 10, no. 4 (2015): 2347-2350. https://doi.org/10.3892/ol.2015.3621
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