Open Access

Overexpression of Ku80 correlates with aggressive clinicopathological features and adverse prognosis in esophageal squamous cell carcinoma

  • Authors:
    • Shuai Wang
    • Zhou Wang
    • Yu Yang
    • Mo Shi
    • Zhenguo Sun
  • View Affiliations

  • Published online on: August 25, 2015     https://doi.org/10.3892/ol.2015.3635
  • Pages: 2705-2712
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ku80, a subunit of the heterodymeric Ku protein, is clearly implicated in nonhomologous end joining DNA repair, chemoresistance and radioresistance in malignant tumors. In the present study, the clinicopathological significance of Ku80 in esophageal squamous cell carcinoma (ESCC) was investigated. The expression levels of Ku80 were determined by reverse transcription‑quantitative polymerase chain reaction and immunohistochemistry in ESCC specimens and normal esophageal mucosa. The mRNA and protein levels of Ku80 were significantly higher in ESCC tissues than in normal esophageal mucosa, and were significantly associated with tumor differentiation, local invasion, lymph node metastasis and tumor‑node‑metastasis (TNM) stage. However, overexpression of Ku80 mRNA and protein levels were not significantly correlated with age, gender, tumor site or tumor size. Cox proportional hazards regression model demonstrated that tumor local invasion, lymph node metastasis, TNM stage and Ku80 mRNA and protein levels were independent risk factors indicating the overall survival of patients with ESCC. The present study demonstrated that aberrant Ku80 overexpression is observed in ESCC. In addition, high expression levels of Ku80 are associated with adverse clinicopathological features and unfavorable prognosis in ESCC patients.
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November-2015
Volume 10 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang S, Wang Z, Yang Y, Shi M and Sun Z: Overexpression of Ku80 correlates with aggressive clinicopathological features and adverse prognosis in esophageal squamous cell carcinoma. Oncol Lett 10: 2705-2712, 2015
APA
Wang, S., Wang, Z., Yang, Y., Shi, M., & Sun, Z. (2015). Overexpression of Ku80 correlates with aggressive clinicopathological features and adverse prognosis in esophageal squamous cell carcinoma. Oncology Letters, 10, 2705-2712. https://doi.org/10.3892/ol.2015.3635
MLA
Wang, S., Wang, Z., Yang, Y., Shi, M., Sun, Z."Overexpression of Ku80 correlates with aggressive clinicopathological features and adverse prognosis in esophageal squamous cell carcinoma". Oncology Letters 10.5 (2015): 2705-2712.
Chicago
Wang, S., Wang, Z., Yang, Y., Shi, M., Sun, Z."Overexpression of Ku80 correlates with aggressive clinicopathological features and adverse prognosis in esophageal squamous cell carcinoma". Oncology Letters 10, no. 5 (2015): 2705-2712. https://doi.org/10.3892/ol.2015.3635