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Article

Treatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study

  • Authors:
    • Peijing Li
    • Weihan Hu
    • Yuan Zhu
    • Jianjiang Liu
  • View Affiliations / Copyright

    Affiliations: Sun Yat‑Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China, Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China, Department of Radiation Oncology, Shaoxing People's Hospital, Shaoxing, Zhejiang 312000, P.R. China
  • Pages: 3145-3152
    |
    Published online on: August 25, 2015
       https://doi.org/10.3892/ol.2015.3640
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Abstract

The aim of the present retrospective analysis was to evaluate the treatment results for recurrent laryngeal cancer and to analyze the factors that may affect survival. A retrospective review was performed in 309 patients with recurrent laryngeal carcinoma, 224 of whom were treated between 1996 and 2009 at Sun Yat‑Sen University Cancer Center (Guangzhou, Guangdong, China) and 85 of whom were treated between 2006 and 2013 at Zhejiang Cancer Hospital (Hangzhou, Zhejiang, China). The Kaplan‑Meier method with the log‑rank computation was used for the analysis of survival. The Cox proportional hazards model was applied to identify covariates that were significantly associated with overall survival. The actuarial 3‑, 5‑ and 10‑year survival rates were 68.9, 53.6 and 35.7%, respectively. Univariate analysis indicated that the following factors were associated with survival: Age, smoking index, tumor grade, primary tumor site, nodal status of the primary tumor, initial T stage, initial Union for International Cancer Control stage, initial treatment (radiotherapy or chemotherapy), disease‑free interval, eligibility for surgery and extent of recurrence. Multivariate analysis of these factors indicated that the initial T stage, tumor grade, nodal status, disease‑free interval and eligibility for surgery were significantly associated with survival. Overall, these results indicate that initial tumor stage T1 or T2, a high differentiation rate, no initial cervical lymph node metastasis, a long disease‑free interval and a strong indication for salvage surgery are good prognostic factors for the survival of patients with recurrent laryngeal carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Li P, Hu W, Zhu Y and Liu J: Treatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study. Oncol Lett 10: 3145-3152, 2015.
APA
Li, P., Hu, W., Zhu, Y., & Liu, J. (2015). Treatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study. Oncology Letters, 10, 3145-3152. https://doi.org/10.3892/ol.2015.3640
MLA
Li, P., Hu, W., Zhu, Y., Liu, J."Treatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study". Oncology Letters 10.5 (2015): 3145-3152.
Chicago
Li, P., Hu, W., Zhu, Y., Liu, J."Treatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study". Oncology Letters 10, no. 5 (2015): 3145-3152. https://doi.org/10.3892/ol.2015.3640
Copy and paste a formatted citation
x
Spandidos Publications style
Li P, Hu W, Zhu Y and Liu J: Treatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study. Oncol Lett 10: 3145-3152, 2015.
APA
Li, P., Hu, W., Zhu, Y., & Liu, J. (2015). Treatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study. Oncology Letters, 10, 3145-3152. https://doi.org/10.3892/ol.2015.3640
MLA
Li, P., Hu, W., Zhu, Y., Liu, J."Treatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study". Oncology Letters 10.5 (2015): 3145-3152.
Chicago
Li, P., Hu, W., Zhu, Y., Liu, J."Treatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study". Oncology Letters 10, no. 5 (2015): 3145-3152. https://doi.org/10.3892/ol.2015.3640
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