Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2015 Volume 10 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2015 Volume 10 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

HO-1, RET and PML as possible markers for risk stratification of acute myelocytic leukemia and prognostic evaluation

  • Authors:
    • Meisheng Yu
    • Jishi Wang
    • Dan Ma
    • Shuya Chen
    • Xiaojing Lin
    • Qin Fang
    • Nana Zhe
  • View Affiliations / Copyright

    Affiliations: Clinical Medical College, Guiyang Medical University, Guiyang, Guizhou 550004, P.R. China, Guizhou Province Laboratory of Hematopoietic Stem Cell Transplantation Centre, Affiliated Hospital of Guiyang Medical University, Guiyang, Guizhou 550004, P.R. China, Department of Pharmacy, Affiliated Baiyun Hospital of Guiyang Medical University, Guiyang, Guizhou 550058, P.R. China
  • Pages: 3137-3144
    |
    Published online on: August 26, 2015
       https://doi.org/10.3892/ol.2015.3644
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Heme oxygenase-1 (HO-1) is an inducible isoform of HO that is activated in response to oxidative stress and has anti‑apoptotic and pro‑proliferative effects on leukemia cells. RET, a tyrosine kinase receptor; its expression levels are associated with the differentiation degree of acute myelocytic leukemia (AML) cells. The promyelocytic leukemia (PML) gene inhibits cell proliferation and tumor growth, participates in the differentiation of hematopoietic progenitor cells and induces cell apoptosis. However, the association between the expression levels of HO‑1, RET and PML genes and the risk stratification of AML and prognosis have not previously been reported. In the present study, HO‑1 was expressed in the human AML Kasumi‑1, HL‑60 and THP‑1 cell lines, and HO‑1 expression was regulated by Hemin (20 µmol/l) and ZnPPIX (10 µmol/l). Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analysis demonstrated that expression of RET and PML were positively and negatively correlated with HO‑1 expression, respectively. Bone marrow samples (18 favorable, 55 intermediate, 15 adverse and 2 unknown karyotype AML cases and 20 healthy donors) were collected from 90 randomly selected AML patients upon their first visit. The mRNA and protein expression of HO‑1, RET and PML in samples was detected by RT‑qPCR and western blot analysis. At the mRNA level, the adverse group expressed significantly higher levels of HO‑1 and RET compared with the levels in the favorable and normal groups. The PML mRNA expression levels in adverse patient samples was lower compared with those of the intermediate group and favorable group. Western blot analysis demonstrated that the expression levels of HO‑1, RET and PML proteins in all risk groups exhibited the same pattern of expression as was observed for the mRNA levels. The overall survival and relapse‑free survival rates were shortest in AML patients with high HO‑1 expression (Kaplan‑Meier; log‑rank, P<0.01). The results of the present study therefore indicate that HO‑1, RET and PML may be critical in the risk‑stratification and prognosis of AML. However, additional samples and clinical data should be collected and analyzed in order to provide stronger evidence for this hypothesis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Rubnitz JE, Gibson B and Smith FO: Acute myeloid leukemia (Review). Pediatr Clin North Am. 55:21–51. 2008. View Article : Google Scholar : PubMed/NCBI

2 

de Nully Brown P, Jurlander J, Pedersen-Bjergaard J, et al: The prognostic significance of chromosomal analysis and immunophenotyping in 117 patients with de novo acute myeloid leukemia. Leuk Res. 21:985–995. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Tian Y, Huang Z, Wang Z, et al: Identification of novel molecular markers for prognosis estimation of acute myeloid leukemia: Over-expression of PDCD7, FIS1 and Ang2 may indicate poor prognosis in pretreatment patients with acute myeloid leukemia. PLoS One. 9:e841502014. View Article : Google Scholar : PubMed/NCBI

4 

Damm F, Heuser M, Morgan M, et al: Integrative prognostic risk score in acute myeloid leukemia with normal karyotype. Blood. 117:4561–4568. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Heasma SA, Zaiseva L, Bowles KM, et al: Protection of acute myeloid leukemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxyenase-1. Oncotarget. 2:658–668. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Wu RP, Hayashi T, Cottam HB, Jin G, Yao S, Wu CC, Rosenbach MD, Corr M, Schwab RB and Carson DA: Nrf2 responses and the theraputic selectivity of electrophilic compounds in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 107:7479–7484. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Nishiya T, Kataoka H, Mori K, Goto M, Sugawara T and Furuhama K: Tienilic acid enhances hyperbilirubinemia in Eisai hyperbilirubinuria rats through hepatic multidrug resistance-associated protein 3 and heme oxygenase-1 induction. Toxicol Sci. 91:651–659. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Hileman EO, Liu J, Albitar M, Keating MJ and Huang P: Intrinsic oxidative stress in cancer cells: A biochemical basis for therapeutic selectivity. Cancer Chemother Pharmacol. 53:209–219. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Fang J, Sawa T, Akaike T, Greish K and Maeda H: Enhancement of cheotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated znic protoporphyrin. Int J Cancer. 109:1–8. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Zou M, Baitei EY, Alzahrani AS, BinHumaid FS, Alkhafaji D, Al-Rijjal RA, Meyer BF and Shi Y: Concomitant RAS, RET/PTC, or BRAF mutations in advanced stage of papillary thyroid carcinoma. Thyroid. 24:1255–1266. 2014. View Article : Google Scholar

11 

Zhang F, Tang JM, Wang L, Wu PP and Zhang M: Immunohistochemical detection of RET proto-oncogene product in tumoral and nontumoral mucosae of gastric cancer. Anal Quant Cytopathol Histpathol. 36:128–136. 2014.PubMed/NCBI

12 

Gattei V, Degan M, Aldinucci D, De Iuliis A, Rossi FM, Mazzocco FT, Rupolo M, Zagonel V and Pinto A: Differential expression of the RET gene in human acute myeloid leukemia. Ann Hematol. 77:207–210. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Wang ZG, Delva L, Gaboli M, Rivi R, Giorgio M, Cordon-Cardo C, Grosveld F and Pandolfi PP: Role of PML in cell grow and the retinoic acid pathway. Science. 279:1547–1551. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Gambaeorta M, Flenghi L, Fagioli M, Pileri S, Leoncini L, Bigerna B, Pacini R, Tanci LN, Pasqualucci L, Ascani S, et al: Heterogeneous nuclear expression of the promyelocytic leukemia (PML) protein in normal and neoplastic human tissues. Am Pathol. 149:2023–2035. 1996.

15 

Gurrieri C, Capodieci P, Bernardi R, Scaglioni PP, Nafa K, Rush LJ, Verbel DA, Cordon-Cardo C and Pandolfi PP: Loss of the tumor suppressor PML in human cancers of multiple histologic origins. J NatL Cancer Inst. 96:269–279. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Koken M, Linare-Cruz G, Quignon F, Viron A, Chelbi-Alix MK, Sobczak-Thépot J, Juhlin L, Degos L, Calvo F and de Thé H: The PML growth-suppressior has altered expression in human oncogenesis. Oncogene. 10:1315–1324. 1995.PubMed/NCBI

17 

Cao TY, Duprez E, Borden KL, Freemont PS and Etkin LD: Ret finger protein is a normal component of PML nuclear bodies and interacts directly wity PML. J Cell Sci. 111:1319–1329. 1998.PubMed/NCBI

18 

Slovak ML, Kopecky KJ, Cassileth PA, Harrington DH, Theil KS, Mohamed A, Paietta E, Willman CL, Head DR, Rowe JM, et al: Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: A Southwest Oncology Group/Eastern Cooperative Oncology Group study. Blood. 96:4075–4083. 2000.PubMed/NCBI

19 

O'Donnell MR, Abboud CN, Altman J, et al: Acute myeloid leukemia. J Natl Compr Cancer Netw. 10:984–1021. 2012.

20 

Döhner H, Estey EH, Amadori S, et al: Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European Leukemia Net. Blood. 115:453–474. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Sanchez M, Levine RL and Rampal R: Integrating genomics into prognostic models for AML. Semin Hematol. 51:298–305. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Juliusson G, Antunovic P, Derolf A, et al: Age and acute myeloid leukemia: Real world data on decision to treat and outcomes from the Swedish acute leukemia registry. Blood. 113:4179–4187. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Berberat PO, Dambrauskas Z, Gulbinas A, Giese T, Giese N, Künzli B, Autschbach F, Meuer S, Büchler MW and Friess H: Inhibition of heme oxygenase-1 increase responsiveness of pancreatic cancer cells to anticancer treatment. Clin Cancer Res. 11:3790–3798. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Mcalliister SC, Hansen SG, Ruhl RA, Raggo CM, DeFilippis VR, Greenspan D, Früh K and Moses AV: Kaposi sarcoma-associated herpesvirus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cells. Blood. 103:3465–3473. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Was H, Dulak J and Jozkowica A: Heme Oxygenase-1 in tumor biology and therapy. Curr Drug Targets. 11:1551–1570. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Miyazaki T, Kirino Y, Takeno M, Samukawa S, Hama M, Tanaka M, Yamaji S, Ueda A, Tomita N, Fujita H and Ishigatsubo Y: Expression of heme oxygenase-1 in human leukemia cells and its regulation by transcriptional repressor Bach1. Cancer Sci. 101:1409–1416. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Rushworth SA and MacEwan DJ: HO-1 underlies resistance of AML cells to TNF-induced apoptosis. Blood. 111:3793–3801. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Mayerhofer M, Florian S, Krauth MT, Aichberger KJ, Bilban M, Marculescu R, Printz D, Fritsch G, Wagner O and Selzer E: Identification of heme oxygenase-1 as a novel BCR/ABL-dependent survival factor in chronic myeloid leukemia. Cancer Res. 64:3148–3154. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Jensen K, Shiels C and Freemont PS: PML protein isoforms and the RBCC/TRIM motif. Oncogene. 20:7223–7233. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Rego EM, Wang ZG, Peruzzi D, He LZ, Cordon-Cardo C and Pandolfi PP: Role of promyelocytic leukemia (PML) protein in tumor suppression. J Exp Med. 193:521–529. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Szendefi M, Walt H, Krasieva TB, Caduff R, Osann KE and LaMorte VJ: Association between promyelocyte protein and smallubiquitin-like modifier protein and the progression of cervical neoplasia. Obstet Gynecol. 102:1269–1277. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Mu ZM, Chin KV, Liu JH, Lozano G and Chang KS: PML a growth suppressor disrupted in acute promyelocytic leukemia. Mol Cell Biol. 14:6858–6867. 1994.PubMed/NCBI

33 

Liu JH, Mu ZM and Chang KS: PML suppresses oncogenic-transformation of NIH 3T3 cells by activated neu. J Exp Med. 181:1965–1973. 1995. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yu M, Wang J, Ma D, Chen S, Lin X, Fang Q and Zhe N: HO-1, RET and PML as possible markers for risk stratification of acute myelocytic leukemia and prognostic evaluation. Oncol Lett 10: 3137-3144, 2015.
APA
Yu, M., Wang, J., Ma, D., Chen, S., Lin, X., Fang, Q., & Zhe, N. (2015). HO-1, RET and PML as possible markers for risk stratification of acute myelocytic leukemia and prognostic evaluation. Oncology Letters, 10, 3137-3144. https://doi.org/10.3892/ol.2015.3644
MLA
Yu, M., Wang, J., Ma, D., Chen, S., Lin, X., Fang, Q., Zhe, N."HO-1, RET and PML as possible markers for risk stratification of acute myelocytic leukemia and prognostic evaluation". Oncology Letters 10.5 (2015): 3137-3144.
Chicago
Yu, M., Wang, J., Ma, D., Chen, S., Lin, X., Fang, Q., Zhe, N."HO-1, RET and PML as possible markers for risk stratification of acute myelocytic leukemia and prognostic evaluation". Oncology Letters 10, no. 5 (2015): 3137-3144. https://doi.org/10.3892/ol.2015.3644
Copy and paste a formatted citation
x
Spandidos Publications style
Yu M, Wang J, Ma D, Chen S, Lin X, Fang Q and Zhe N: HO-1, RET and PML as possible markers for risk stratification of acute myelocytic leukemia and prognostic evaluation. Oncol Lett 10: 3137-3144, 2015.
APA
Yu, M., Wang, J., Ma, D., Chen, S., Lin, X., Fang, Q., & Zhe, N. (2015). HO-1, RET and PML as possible markers for risk stratification of acute myelocytic leukemia and prognostic evaluation. Oncology Letters, 10, 3137-3144. https://doi.org/10.3892/ol.2015.3644
MLA
Yu, M., Wang, J., Ma, D., Chen, S., Lin, X., Fang, Q., Zhe, N."HO-1, RET and PML as possible markers for risk stratification of acute myelocytic leukemia and prognostic evaluation". Oncology Letters 10.5 (2015): 3137-3144.
Chicago
Yu, M., Wang, J., Ma, D., Chen, S., Lin, X., Fang, Q., Zhe, N."HO-1, RET and PML as possible markers for risk stratification of acute myelocytic leukemia and prognostic evaluation". Oncology Letters 10, no. 5 (2015): 3137-3144. https://doi.org/10.3892/ol.2015.3644
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team