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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Effect of camptothecin on inducible nitric oxide synthase expression in the colon cancer SW480 cell line

  • Authors:
    • Xiangdi Shen
    • Jian Chen
    • Rong Qiu
    • Xingli Fan
    • Ying Xin
  • View Affiliations / Copyright

    Affiliations: Department of Basic Science, Zhejiang Medical College, Hangzhou, Zhejiang 310053, P.R. China, Department of General Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China
  • Pages: 3157-3160
    |
    Published online on: September 2, 2015
       https://doi.org/10.3892/ol.2015.3658
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Abstract

As a topoisomerase I inhibitor, camptothecin (CPT) is regarded as an effective antitumor agent. In an attempt to search for its novel anticancer mechanism, the present study evaluated the effects of CPT on inducible nitric oxide synthase (iNOS) in the human colon cancer SW480 cell line when stimulated with lipopolysaccharide (LPS) and interleukin (IL)‑1β. The data indicated that CPT significantly decreased NO production. Consistent with these observations, the protein and mRNA expression levels of iNOS were inhibited by CPT in a dose‑dependent manner. Thus, the inhibitory effects of CPT on LPS/IL‑1β‑stimulated NO production were likely mediated via the inhibition of iNOS gene transcription. From these results, we propose that the inhibition of NO biosynthesis by CPT may partially underlie the efficacy of this antitumor agent.
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1 

Wall ME, Wani MC, Cook CE, Palmer KH, McPhail AT and Sim GA: Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca accuminata. J Am Chem Soc. 88:3888–3890. 1966. View Article : Google Scholar

2 

Garcia-Carbonero R and Supko JG: Current perspectives on the clinical experience, pharmacology and continued development of the camptothecins. Clin Cancer Res. 8:641–661. 2002.PubMed/NCBI

3 

Hsiang YH, Wu HY and Liu LF: Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells. Cancer Res. 48:3230–3235. 1988.PubMed/NCBI

4 

Abounader R, Reznik T, Colantuoni C, Martinez-Murillo F, Rosen EM and Laterra J: Regulation of c-Met-dependent gene expression by PTEN. Oncogene. 23:9173–9182. 2004.PubMed/NCBI

5 

Hamano Y and Kalluri R: Tumstatin, the NC1 domain of alpha3 chain of type IV collagen, is an endogenous inhibitor of pathological angiogenesis and suppresses tumor growth. Biochem Biophys Res Commun. 333:292–298. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Fox SB, Gatter KC, Bicknell R, Going JJ, Stanton P, Cooke TG and Harris AL: Relationship of endothelial cell proliferation to tumor vascularity in human breast cancer. Cancer Res. 53:4161–4163. 1993.PubMed/NCBI

7 

D'Amato RJ, Loughnan MS, Flynn E and Folkman J: Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci U S A. 91:4082–4085. 1994. View Article : Google Scholar : PubMed/NCBI

8 

Bezerra Y, Fuselier JA, Peyman GA, Oner H, Drouant G and Coy DH: Study of inhibitory effects of an antiangiogenic somatostatin-camptothecin conjugate on laser-induced choroidal neovasculrization in rats. Retina. 25:345–354. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Panrazis P, Han Z, Balan K, Wang Y and Wyche JH: Camptothecin and 9-nitrocamptothecin (9NC) as anti-cancer anti-HIV and cell-differentiation agents. Development of resistance, enhancement of 9NC-induced activities and combination treatments in cell and animal models. Anticancer Res. 23:3623–3638. 2003.PubMed/NCBI

10 

Jenkins DC, Charlies IG, Thomsen LL, Moss DW, Holmes LS, Baylis SA, Rhodes P, Westmore K, Emson PC and Moncada S: Roles of nitric oxide in tumor growth. Proc Natl Acad Sci USA. 92:4392–4396. 1995. View Article : Google Scholar : PubMed/NCBI

11 

Klotz T, Bloch W, Jacobs G, Niggemann S, Engelmann U and Addicks K: Immunolocalization of inducible and constitutive nitric oxide synthases in human bladder cancer. Urology. 54:416–419. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Zhang GL, Wang YH, Teng HL and Lin ZB: Effects of aminoguanidine on nitric oxide production induced by inflammatory cytokines and endotoxin in cultured rat hepatocytes. World J Gastroenterol. 7:331–334. 2001.PubMed/NCBI

13 

Jenkins DC, Charles IG, Baylis SA, Lelchuk R, Radomski MW and Moncada S: Human colon cancer cell lines show a diverse pattern of nitric oxide synthase gene expression and nitric oxide generation. Br J Cancer. 70:847–849. 1994. View Article : Google Scholar : PubMed/NCBI

14 

Sherman PA, Lanbach VE, Reep BR and Wood ER: Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line. Biochemistry. 32:11600–11605. 1993. View Article : Google Scholar : PubMed/NCBI

15 

Franchi A, Gallo O, Paglierani M, Sardi I, Magnelli L, Masini E and Santucci M: Inducible nitric oxide synthase expression in laryngeal neoplasia: Correlation with angiogenesis. Head Neck. 24:16–23. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Son HJ, Kim YH, Park DI, Kim JJ, Rhee PL, Paik SW, Choi KW, Song SY and Rhee JC: Interaction between cyclooxygenase-2 and inducible nitric oxide synthase in gastric cancer. J Clin Gastroenterol. 33:383–388. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Ray GN, Shahid M and Hasain SA: Effect of nitric oxide and malondialdehyde on sister-chromatid exchanges in breast cancer. Br J Biomed Sci. 58:169–176. 2001.PubMed/NCBI

18 

Chiou WF, Chou CJ and Chen CF: Camptothecin suppresses nitric oxide biosynthesis in RAW 264.7 macrophages. Life Sci. 69:625–635. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS and Tannenbaum SR: Analysis of nitrate, nitrite and 15 Nnitrate in biological fluids. Anal Biochem. 126:131–138. 1982. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shen X, Chen J, Qiu R, Fan X and Xin Y: Effect of camptothecin on inducible nitric oxide synthase expression in the colon cancer SW480 cell line. Oncol Lett 10: 3157-3160, 2015.
APA
Shen, X., Chen, J., Qiu, R., Fan, X., & Xin, Y. (2015). Effect of camptothecin on inducible nitric oxide synthase expression in the colon cancer SW480 cell line. Oncology Letters, 10, 3157-3160. https://doi.org/10.3892/ol.2015.3658
MLA
Shen, X., Chen, J., Qiu, R., Fan, X., Xin, Y."Effect of camptothecin on inducible nitric oxide synthase expression in the colon cancer SW480 cell line". Oncology Letters 10.5 (2015): 3157-3160.
Chicago
Shen, X., Chen, J., Qiu, R., Fan, X., Xin, Y."Effect of camptothecin on inducible nitric oxide synthase expression in the colon cancer SW480 cell line". Oncology Letters 10, no. 5 (2015): 3157-3160. https://doi.org/10.3892/ol.2015.3658
Copy and paste a formatted citation
x
Spandidos Publications style
Shen X, Chen J, Qiu R, Fan X and Xin Y: Effect of camptothecin on inducible nitric oxide synthase expression in the colon cancer SW480 cell line. Oncol Lett 10: 3157-3160, 2015.
APA
Shen, X., Chen, J., Qiu, R., Fan, X., & Xin, Y. (2015). Effect of camptothecin on inducible nitric oxide synthase expression in the colon cancer SW480 cell line. Oncology Letters, 10, 3157-3160. https://doi.org/10.3892/ol.2015.3658
MLA
Shen, X., Chen, J., Qiu, R., Fan, X., Xin, Y."Effect of camptothecin on inducible nitric oxide synthase expression in the colon cancer SW480 cell line". Oncology Letters 10.5 (2015): 3157-3160.
Chicago
Shen, X., Chen, J., Qiu, R., Fan, X., Xin, Y."Effect of camptothecin on inducible nitric oxide synthase expression in the colon cancer SW480 cell line". Oncology Letters 10, no. 5 (2015): 3157-3160. https://doi.org/10.3892/ol.2015.3658
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