Open Access

Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature

  • Authors:
    • Zhe-Yi Dong
    • Hai-Tao Xing
    • Yuan-Da Wang
    • Wei Zhang
    • Qiang Qiu
    • Xiang-Mei Chen
  • View Affiliations

  • Published online on: September 3, 2015     https://doi.org/10.3892/ol.2015.3669
  • Pages: 2821-2827
  • Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The presentation of focal segmental glomerulosclerosis (FSGS) and multiple myeloma (MM), either together or in succession, is extremely rare. Only nine studies have previously reported this poorly understood association. The present study reports the case of a 45-year-old male with FSGS that was diagnosed by a renal biopsy performed for nephrotic syndrome (NS). The patient was admitted to the Chinese People's Liberation Army General Hospital one year later with a fever, anemia, unresolved NS and renal insufficiency. The patient was diagnosed with MM and a renal biopsy was repeated, the results of which suggested renal amyloidosis. The MM was treated with three cycles of vincristine, doxorubicin and dexamethasone chemotherapy. A review of the literature indicated that monoclonal gammopathy may lead to FSGS. It suggested that FSGS patients who are >40 years old should be routinely screened for plasma cell proliferative disorders to guide the treatment, determine a prognosis, achieve primary disease remission and avoid end‑stage renal disease.
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November-2015
Volume 10 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Dong Z, Xing H, Wang Y, Zhang W, Qiu Q and Chen X: Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature. Oncol Lett 10: 2821-2827, 2015.
APA
Dong, Z., Xing, H., Wang, Y., Zhang, W., Qiu, Q., & Chen, X. (2015). Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature. Oncology Letters, 10, 2821-2827. https://doi.org/10.3892/ol.2015.3669
MLA
Dong, Z., Xing, H., Wang, Y., Zhang, W., Qiu, Q., Chen, X."Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature". Oncology Letters 10.5 (2015): 2821-2827.
Chicago
Dong, Z., Xing, H., Wang, Y., Zhang, W., Qiu, Q., Chen, X."Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature". Oncology Letters 10, no. 5 (2015): 2821-2827. https://doi.org/10.3892/ol.2015.3669