Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature

Dong,Zhe-Yi; Xing,Hai-Tao; Wang,Yuan-Da; Zhang,Wei; Qiu,Qiang; Chen,Xiang-Mei

doi:10.3892/ol.2015.3669

November-2015 Volume 10 Issue 5

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November-2015 Volume 10 Issue 5

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Case Report Open Access

Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature

Authors:
- Zhe-Yi Dong
- Hai-Tao Xing
- Yuan-Da Wang
- Wei Zhang
- Qiang Qiu
- Xiang-Mei Chen
View Affiliations / Copyright

Affiliations: Department of Nephrology, State Key Laboratory of Kidney Disease, National Clinical Research Center for Kidney Disease, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China

Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 2821-2827
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Published online on: September 3, 2015

https://doi.org/10.3892/ol.2015.3669
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Abstract

The presentation of focal segmental glomerulosclerosis (FSGS) and multiple myeloma (MM), either together or in succession, is extremely rare. Only nine studies have previously reported this poorly understood association. The present study reports the case of a 45-year-old male with FSGS that was diagnosed by a renal biopsy performed for nephrotic syndrome (NS). The patient was admitted to the Chinese People's Liberation Army General Hospital one year later with a fever, anemia, unresolved NS and renal insufficiency. The patient was diagnosed with MM and a renal biopsy was repeated, the results of which suggested renal amyloidosis. The MM was treated with three cycles of vincristine, doxorubicin and dexamethasone chemotherapy. A review of the literature indicated that monoclonal gammopathy may lead to FSGS. It suggested that FSGS patients who are >40 years old should be routinely screened for plasma cell proliferative disorders to guide the treatment, determine a prognosis, achieve primary disease remission and avoid end‑stage renal disease.

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1	Paueksakon P, Revelo MP, Horn RG, Shappell S and Fogo AB: Monoclonal gammopathy: Significance and possible causality in renal disease. Am J Kidney Dis. 42:87–95. 2003. View Article : Google Scholar : PubMed/NCBI
2	Dingli D, Larson DR, Plevak MF, Grande JP and Kyle RA: Focal and segmental glomerulosclerosis and plasma cell proliferative disorders. Am J Kidney Dis. 46:278–282. 2005. View Article : Google Scholar : PubMed/NCBI
3	Gertz MA: Utility of the immunoglobulin free light chain assay for plasma cell disorders 2015. Leuk Lymphoma. March 27–2015.((Epub ahead of print))
4	Deegens JK, Steenbergen EJ and Wetzels JF: Review on diagnosis and treatment of focal segmental glomerulosclerosis. Neth J Med. 66:3–12. 2008.PubMed/NCBI
5	Shah S, Cavenagh J, Sheaf M and Thuraisingham RC: Remission of collapsing focal segmental glomerulosclerosis following chemotherapy for myeloma. Am J Kidney Dis. 43:e10–e12. 2004. View Article : Google Scholar : PubMed/NCBI
6	Jain N, Tantaco MR, Thomas B and Laut J: Monoclonal gammopathy of uncertain significance (MGUS) and focal segmental glomerulosclerosis (FSGS) - A case report. Am J Kidney Dis. 55:B562010. View Article : Google Scholar
7	Ashrafi F, Mortazavi M, Manouchehri N, Moghaddam NA, Nasri H and Sarrami AH: Focal segmental glomerulosclerosis, secondary amyloidosis and multiple myeloma. Pak J Med Sci. 28:345–347. 2012.
8	Torun D, Canpolat T and Özelsancak R: Focal Segmental Glomerulosclerosis in a patient associated with kappa-light chain disease. Turk Neph Dial Transpl. 20:96–98. 2011. View Article : Google Scholar
9	Matsuyama N, Joh K, Yamaguchi Y, et al: Crystalline inclusions in the glomerular podocytes in a patient with benign monoclonal gammopathy and focal segmental glomerulosclerosis. Am J Kidney Dis. 23:859–865. 1994. View Article : Google Scholar : PubMed/NCBI
10	Valizadeh N, Makhdomi K, Noroozinia F and Behzadi F: Multiple myeloma presenting with focal segmental glomerulosclerosis. South Asian J Cancer. 2:1682013. View Article : Google Scholar : PubMed/NCBI
11	Charney DA and Wasser W: A 36-year-old man with a monoclonal gammopathy and nephrotic syndrome. Am J Kidney Dis. 42:1097–1101. 2003. View Article : Google Scholar : PubMed/NCBI
12	Shah R, Shah N, Shah A and Mehta AN: Steroid-resistant nephrotic syndrome secondary to primary focal segmental glomerulosclerosis and smoldering multiple myeloma. Proc (Bayl Univ Med Cent). 27:19–21. 2014.PubMed/NCBI
13	Belghiti D, Vernant JP, Hirbec G, Gubler MC, Andre C and Sobel A: Nephrotic syndrome associated with T-cell lymphoma. Cancer. 47:1878–1882. 1981. View Article : Google Scholar : PubMed/NCBI
14	Hyman LR, Burkholder PM, Joo PA and Segar WE: Malignant lymphoma and nephrotic syndrome. A clinicopathologic analysis with light, immunofluorescence, and electron microscopy of the renal lesions. J Pediatr. 82:207–212. 1973. View Article : Google Scholar : PubMed/NCBI
15	Bassan R, Rambaldi A, Abbate M, et al: Association of NK-cell lymphoproliferative disease and nephrotic syndrome. Am J Clin Pathol. 94:334–338. 1990.PubMed/NCBI
16	Bose B and Cattran D: Toronto Glomerulonephritis Registry: Glomerular diseases: FSGS. Clin J Am Soc Nephrol. 9:626–632. 2014. View Article : Google Scholar : PubMed/NCBI
17	Nasr SH, Preddie DC, Markowitz GS, Appel GB and D'Agati VD: Multiple myeloma, nephrotic syndrome and crystalloid inclusions in podocytes. Kidney Int. 69:616–620. 2006. View Article : Google Scholar : PubMed/NCBI
18	Brenchley PE: Vascular permeability factors in steroid-sensitive nephrotic syndrome and focal segmental glomerulosclerosis. Nephrol Dial Transplant. 18(Suppl 6): vi21–vi25. 2003.PubMed/NCBI
19	Rajkumar SV and Kyle RA: Angiogenesis in multiple myeloma. Semin Oncol. 28:560–564. 2001. View Article : Google Scholar : PubMed/NCBI
20	Rajkumar SV, Mesa RA, Fonseca R, et al: Bone marrow angiogenesis in 400 patients with monoclonal gammopathy of undetermined significance, multiple myeloma, and primary amyloidosis. Clin Cancer Res. 8:2210–2216. 2002.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature

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