Uncommon gastrointestinal bleeding during targeted therapy for advanced renal cell carcinoma: A report of four cases

Fujihara,Shintaro; Mori,Hirohito; Kobara,Hideki; Nishiyama,Noriko; Ayaki,Maki; Ohata,Ryo; Ueda,Nobufumi; Sugimoto,Mikio; Kakehi,Yoshiyuki; Masaki,Tsutomu

doi:10.3892/ol.2015.3671

November-2015 Volume 10 Issue 5

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November-2015 Volume 10 Issue 5

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Article

Uncommon gastrointestinal bleeding during targeted therapy for advanced renal cell carcinoma: A report of four cases

Authors:
- Shintaro Fujihara
- Hirohito Mori
- Hideki Kobara
- Noriko Nishiyama
- Maki Ayaki
- Ryo Ohata
- Nobufumi Ueda
- Mikio Sugimoto
- Yoshiyuki Kakehi
- Tsutomu Masaki
View Affiliations / Copyright

Affiliations: Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Kagawa 761‑0793, Japan, Department of Urology, Tottori Red Cross Hospital, Tottori 680‑8517, Japan, Department of Urology, Faculty of Medicine, Kagawa University, Kagawa 761‑0793, Japan
Pages: 2895-2898
|
Published online on: September 3, 2015

https://doi.org/10.3892/ol.2015.3671
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Abstract

Clinically available targeted agents to treat advanced renal cell carcinoma (RCC) include sunitinib, sorafenib and temsirolimus. Sorafenib and sunitinib have been associated with bleeding in selected trials, but clinical and endoscopic characteristics of gastrointestinal bleeding are not well described. Herein, we report four cases of advanced RCC in which endoscopic hemostasis effectively resolved high‑grade, life‑threatening gastrointestinal bleeding that occurred during targeted therapy. Although stomatitis and mucositis have occurred during targeted therapies, life‑threatening gastrointestinal bleeding is less common. In these four patients, the origins of gastrointestinal bleeding were identified, and complete endoscopic hemostasis was achieved. Endoscopies revealed variable characteristics including angiodysplasia, multiple gastric ulcers and oozing bleeding of the normal mucosa. Although the most effective diagnostic and treatment strategies are disputed, endoscopic examinations are best performed before starting targeted therapies. Additionally, these patients should be monitored even for rare life‑threatening events.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Uncommon gastrointestinal bleeding during targeted therapy for advanced renal cell carcinoma: A report of four cases

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