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Article

Long‑term treatment of residual or recurrent low‑grade endometrial stromal sarcoma with aromatase inhibitors: A report of two cases and a review of the literature

  • Authors:
    • Hyewon Ryu
    • Yoon‑Seok Choi
    • Ik‑Chan Song
    • Hwan‑Jung Yun
    • Deog‑Yeon Jo
    • Samyong Kim
    • Hyo Jin Lee
  • View Affiliations / Copyright

    Affiliations: Division of Hematology‑Oncology, Department of Internal Medicine, Chungnam National University Hospital, Daejeon 301‑721, Republic of Korea
  • Pages: 3310-3314
    |
    Published online on: September 3, 2015
       https://doi.org/10.3892/ol.2015.3674
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Abstract

Endometrial stromal sarcoma (ESS) occurs rarely and accounts for only 0.2% of all uterine malignancies. ESS usually expresses estrogen and progesterone receptors, and is regarded as hormone‑sensitive. Due to the rarity of these tumors, there are only few case series on the use of aromatase inhibitors in the treatment of low‑grade ESS. The present study reports the cases of two patients with residual or recurrent low‑grade ESS who experienced long‑term disease‑free survival following treatment with letrozole. The study also reviews the literature with regard to the data on aromatase inhibitors used in patients with low‑grade ESS. In total, 30 patients with recurrent or residual low‑grade ESS who were treated with aromatase inhibitors were identified, including the present cases. Among the 30 patients, the overall response rate of advanced low‑grade ESS to aromatase inhibitors was 77.4% (complete response, 25.8%; partial response, 51.6%) and the disease control rate was 90.3%. The response rate of first‑line treatment was similar to that of second‑line therapy or higher (84.6 vs. 72.2%; P=0.453). Duration of aromatase inhibitor treatment ranged from 1.5 to 168 months (median, 26.5 months). The aromatase inhibitors showed minimal adverse effects. In conclusion, aromatase inhibitors, particularly third‑generation drugs, are a well‑tolerated class of medications that are effective in the treatment of advanced low‑grade ESS, with a favorable toxicity profile.
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Copy and paste a formatted citation
Spandidos Publications style
Ryu H, Choi YS, Song IC, Yun HJ, Jo DY, Kim S and Lee HJ: Long‑term treatment of residual or recurrent low‑grade endometrial stromal sarcoma with aromatase inhibitors: A report of two cases and a review of the literature. Oncol Lett 10: 3310-3314, 2015.
APA
Ryu, H., Choi, Y., Song, I., Yun, H., Jo, D., Kim, S., & Lee, H.J. (2015). Long‑term treatment of residual or recurrent low‑grade endometrial stromal sarcoma with aromatase inhibitors: A report of two cases and a review of the literature. Oncology Letters, 10, 3310-3314. https://doi.org/10.3892/ol.2015.3674
MLA
Ryu, H., Choi, Y., Song, I., Yun, H., Jo, D., Kim, S., Lee, H. J."Long‑term treatment of residual or recurrent low‑grade endometrial stromal sarcoma with aromatase inhibitors: A report of two cases and a review of the literature". Oncology Letters 10.5 (2015): 3310-3314.
Chicago
Ryu, H., Choi, Y., Song, I., Yun, H., Jo, D., Kim, S., Lee, H. J."Long‑term treatment of residual or recurrent low‑grade endometrial stromal sarcoma with aromatase inhibitors: A report of two cases and a review of the literature". Oncology Letters 10, no. 5 (2015): 3310-3314. https://doi.org/10.3892/ol.2015.3674
Copy and paste a formatted citation
x
Spandidos Publications style
Ryu H, Choi YS, Song IC, Yun HJ, Jo DY, Kim S and Lee HJ: Long‑term treatment of residual or recurrent low‑grade endometrial stromal sarcoma with aromatase inhibitors: A report of two cases and a review of the literature. Oncol Lett 10: 3310-3314, 2015.
APA
Ryu, H., Choi, Y., Song, I., Yun, H., Jo, D., Kim, S., & Lee, H.J. (2015). Long‑term treatment of residual or recurrent low‑grade endometrial stromal sarcoma with aromatase inhibitors: A report of two cases and a review of the literature. Oncology Letters, 10, 3310-3314. https://doi.org/10.3892/ol.2015.3674
MLA
Ryu, H., Choi, Y., Song, I., Yun, H., Jo, D., Kim, S., Lee, H. J."Long‑term treatment of residual or recurrent low‑grade endometrial stromal sarcoma with aromatase inhibitors: A report of two cases and a review of the literature". Oncology Letters 10.5 (2015): 3310-3314.
Chicago
Ryu, H., Choi, Y., Song, I., Yun, H., Jo, D., Kim, S., Lee, H. J."Long‑term treatment of residual or recurrent low‑grade endometrial stromal sarcoma with aromatase inhibitors: A report of two cases and a review of the literature". Oncology Letters 10, no. 5 (2015): 3310-3314. https://doi.org/10.3892/ol.2015.3674
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