Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2015 Volume 10 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2015 Volume 10 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Isolated lymphoma of the optic nerve, chiasm and tract: A case report

  • Authors:
    • Yue‑Li Zhu
    • Xiu‑Feng Song
    • Bin Wang
  • View Affiliations / Copyright

    Affiliations: Shandong Medical Imaging Research Institution, Shandong University, Jinan, Shandong 250021, P.R. China, Department of Radiology, Qingdao University Affiliated Hospital, Qingdao, Shandong 266003, P.R. China
  • Pages: 3013-3017
    |
    Published online on: September 3, 2015
       https://doi.org/10.3892/ol.2015.3675
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The current study reports the case of a 68‑year‑old, previously healthy female who presented with progressive visual impairment leading to blindness bilaterally. Brain imaging features were suggestive of malignant glioma of the anterior visual pathway. Postoperative examination indicated a diagnosis of diffuse malignant lymphoma type B. As no evidence of extracranial lymphoma was observed, the final diagnosis was primary central nervous system lymphoma (PCNSL). Following treatment with surgery and radiotherapy, the patient's symptoms went into remission. At a follow‑up examination 12 months after diagnosis, the patient demonstrated no evidence of recurrence. To the best of our knowledge, PCNSL isolated to the optic chiasm has been reported only three times in immunocompetent patients. Therefore, the present case of the lymphoma involving the optic nerve, optic chiasm and optic tract in an immunocompetent patient is unusual. The present case emphasizes the importance of considering the diagnosis of lymphoma in this setting.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Lee AG, Tang RA, Roberts D, Schiffman JS and Osborne A: Primary central nervous system lymphoma involving the optic chiasm in AIDS. J Neuroophthalmol. 21:95–98. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Eby NL, Grufferman S, Flannelly CM, Schold SC, Vogel FS and Burger PC: Increasing incidence of primary brain lymphoma in the US. Cancer. 62:2461–2465. 1988. View Article : Google Scholar : PubMed/NCBI

3 

Corn BW, Marcus SM, Topham A, Hauck W and Curran WJ: Will primary central nervous system lymphoma be the most frequent brain tumor diagnosed in the year 2000? Cancer. 79:2409–2413. 1997. View Article : Google Scholar : PubMed/NCBI

4 

Deangelis LM and Hormigo A: Treatment of primary central nervous system lymphoma. Semin Oncol. 31:684–692. 2004. View Article : Google Scholar : PubMed/NCBI

5 

del Rio M Sierra, Rousseau A, Soussain C, Ricard D and Hoang-Xuan K: Primary CNS lymphoma in immunocompetent patients. Oncologist. 14:526–539. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Behbehani RS, Vacarezza N, Sergott RC, Bilyk JR, Hochberg F and Savino PJ: Isolated optic nerve lymphoma diagnosed by optic nerve biopsy. Am J Ophthalmol. 139:1128–1130. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Zelefsky JR, Revercomb CH, Lantos G and Warren FA: Isolated lymphoma of the anterior visual pathway diagnosed by optic nerve biopsy. J Neuroophthalmol. 8:36–40. 2008. View Article : Google Scholar

8 

Cantore GP, Raco A, Artico M, Ciappetta P and Delfini R: Primary chiasmatic lymphoma. Clin Neurol Neurosurg. 91:71–74. 1989. View Article : Google Scholar : PubMed/NCBI

9 

Simon RP, Greenberg D and Aminoff MJ: Clinical Neurology (7th). McGraw-Hill Medical. New York, NY: 2009.

10 

Chimienti E, Spina M, Vaccher E and Tirelli U: Management of immunocompetent patients with primary central nervous system lymphoma. Clin Lymphoma Myeloma. 9:353–364. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Bühring U, Herrlinger U, Krings T, Thiex R, Weller M and Küker W: MRI features of primary central nervous system lymphomas at presentation. Neurology. 57:393–396. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Küker W, Nägele T, Korfel A, Heckl S, Thiel E, Bamberg M, Weller M and Herrlinger U: Primary central nervous system lymphomas (PCNSL): Presentation in 100 patients. J Neuro Oncol. 72:169–177. 2005. View Article : Google Scholar

13 

Guo AC, Cummings TJ, Dash RC and Provenzale JM: Lymphomas and high-grade astrocytomas: Comparison of water diffusibility and histologic characteristics. Radiology. 224:177–183. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Go JL, Lee SC and Kim PE: Imaging of primary central nervous system lymphoma. Neurosurg Focus. 21:E42006. View Article : Google Scholar : PubMed/NCBI

15 

Haldorsen IS, Espeland A and Larsson EM: Central Nervous system lymphoma: Characteristic findings on traditional and advanced imaging. AJNR Am J Neuroradiol. 32:984–992. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Ikeda T, Hara K, Yamanaka T, Umezu H, Takahashi H and Nishizawa M: A case of primary central nervous system malignant lymphoma developing from the optic chiasma and hypothalamus Rinsho. Shinkeigaku. 46:475–479. 2006.(In Japanese).

17 

Bullock JD, Yanner B, Kelly M and McDonald LW: Non-Hodgkins lymphoma involving the optic nerve. Ann Ophthalmol. 11:1477–1480. 1979.PubMed/NCBI

18 

Maiuri F: Primary cerebral lymphoma presenting as steroid-responsive chiasmal syndrome. Br J Neurosurg. 1:499–502. 1987. View Article : Google Scholar : PubMed/NCBI

19 

Sakai C, Takagi T and Wakatsuki S: Primary meningeal lymphoma presenting solely with blindness: A report of an autopsy case. Int J Hematol. 63:325–329. 1996. View Article : Google Scholar : PubMed/NCBI

20 

Strominger MB, Schatz NJ and Glaser JS: Lymphomatous optic neuropathy. Am J Ophthalmol. 116:774–776. 1993. View Article : Google Scholar : PubMed/NCBI

21 

Gray RS, Abrahams JJ, Hufnagel TJ, Kim JH, Lesser RL and Spencer DD: Ghost-cell tumor of the optic chiasm: Primary CNS lymphoma. J Clin Neuroophthalmol. 9:98–104. 1989.PubMed/NCBI

22 

Maiuri F: Visual involvement in primary non-Hodgkin's lymphomas. Clin Neurol Neurosurg. 92:119–124. 1990. View Article : Google Scholar : PubMed/NCBI

23 

Bolanowski M, Kuliszkiewicz-Janus M and Sokolska V: Diffuse malignant lymphoma type B with optic chiasm infiltration, visual disturbances, hypopituitarism, hyperprolactinaemia and diabetes insipidus. Case report and literature review. Endokrynol Pol. 57:642–647. 2006.PubMed/NCBI

24 

McFadzean RM, McIlwaine GG and McLellan D: Hodgkin's disease at the optic chiasm. J Clin Neuroophthalmol. 10:248–254. 1990.PubMed/NCBI

25 

Sumrall A and Herrin V: Recurrent, transformed non-Hodgkin's lymphoma presenting as chiasmal syndrome with hyperprolactinemia and hypopituitarism. J Miss State Med Assoc. 51:35–36. 2010.PubMed/NCBI

26 

Soldevilla HF, Molina RM and Navarra SV: Breast lymphoma in Sjögren's syndrome complicated by acute monocular blindness. Int J Rheum Dis. 13:164–170. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Song X, Wang G, Zhang T, Feng L, An P and Zhu Y: Functional magnetic resonance imaging evaluation of visual cortex activation in patients with anterior visual pathway lesions. Neural Regen Res. 7:692–696. 2012.PubMed/NCBI

28 

Quesnel AM and Mckenna MJ: Current strategies in management of intracanalicular vestibular schwanmoma. Curr Opin Otolaryngol Head Neck Surg. 19:335–340. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Wu R, Wang Z, Xian J, et al: Analysis of the optic chiasmal lesions by MRI. Zhonghua Fang She Xue Za Zhi. 37:445–448. 2003.(In Chinese).

30 

Xian J, Wang Z, Yu W, et al: Imaging investigations of optic gliomas. Zhonghua Fang She Xue Za Zhi. 38:677–681. 2004.(In Chinese).

31 

Listernick R, Louis DN, Packer RJ and Gutmann DH: Optic pathway gliomas in children with neurofibromatosis type 1: Consensus statement from the NF1 Optic Glioma Task Force. Ann Neurol. 41:143–149. 1997. View Article : Google Scholar : PubMed/NCBI

32 

Albert A, Lee BC, Saint-Louis L and Deck MD: MRI of optic chiasm and optic pathways. AJNR Am J Neuroradiol. 7:255–258. 1986.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhu YL, Song XF and Wang B: Isolated lymphoma of the optic nerve, chiasm and tract: A case report. Oncol Lett 10: 3013-3017, 2015.
APA
Zhu, Y., Song, X., & Wang, B. (2015). Isolated lymphoma of the optic nerve, chiasm and tract: A case report. Oncology Letters, 10, 3013-3017. https://doi.org/10.3892/ol.2015.3675
MLA
Zhu, Y., Song, X., Wang, B."Isolated lymphoma of the optic nerve, chiasm and tract: A case report". Oncology Letters 10.5 (2015): 3013-3017.
Chicago
Zhu, Y., Song, X., Wang, B."Isolated lymphoma of the optic nerve, chiasm and tract: A case report". Oncology Letters 10, no. 5 (2015): 3013-3017. https://doi.org/10.3892/ol.2015.3675
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu YL, Song XF and Wang B: Isolated lymphoma of the optic nerve, chiasm and tract: A case report. Oncol Lett 10: 3013-3017, 2015.
APA
Zhu, Y., Song, X., & Wang, B. (2015). Isolated lymphoma of the optic nerve, chiasm and tract: A case report. Oncology Letters, 10, 3013-3017. https://doi.org/10.3892/ol.2015.3675
MLA
Zhu, Y., Song, X., Wang, B."Isolated lymphoma of the optic nerve, chiasm and tract: A case report". Oncology Letters 10.5 (2015): 3013-3017.
Chicago
Zhu, Y., Song, X., Wang, B."Isolated lymphoma of the optic nerve, chiasm and tract: A case report". Oncology Letters 10, no. 5 (2015): 3013-3017. https://doi.org/10.3892/ol.2015.3675
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team