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Article Open Access

A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection

  • Authors:
    • Cheng-Zuo Xiao
    • Wei Wei
    • Zhi-Xing Guo
    • Shu-Hong Li
    • Yong-Fa Zhang
    • Jia-Hong Wang
    • Ming Shi
    • Rong-Ping Guo
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Cancer Centre of Sun Yat‑Sen University, Guangzhou, Guangdong 510060, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2787-2794
    |
    Published online on: September 3, 2015
       https://doi.org/10.3892/ol.2015.3677
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Abstract

The present study aimed to identify the risk factors influencing the survival of patients with hepatocellular carcinoma (HCC) affected by portal vein tumor thrombus (PVTT), following hepatic resection, and to establish a prognostic model. Between March 2001 and May 2008, 234 cases of HCC with PVTT that underwent hepatic resection were randomly divided into experimental or validation groups. The association between the clinicopathological factors and disease‑free survival (DFS) and overall survival (OS) was analyzed, and the significant factors involved were used to establish a prognostic model, which was then validated. Tumor rupture, number of tumors and macroscopic vascular invasion were observed to be independent risk factors of DFS and OS. In the prognostic model, the DFS and OS of low‑, medium‑ and high‑risk patients in the experimental group were observed to be significantly different, compared to those in the validation group. In conclusion, the present study established a prognostic model for patients with HCC affected by PVTT following hepatectomy, and demonstrated that the model may be used to guide the treatment of these patients and predict their prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Xiao C, Wei W, Guo Z, Li S, Zhang Y, Wang J, Shi M and Guo R: A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection. Oncol Lett 10: 2787-2794, 2015.
APA
Xiao, C., Wei, W., Guo, Z., Li, S., Zhang, Y., Wang, J. ... Guo, R. (2015). A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection. Oncology Letters, 10, 2787-2794. https://doi.org/10.3892/ol.2015.3677
MLA
Xiao, C., Wei, W., Guo, Z., Li, S., Zhang, Y., Wang, J., Shi, M., Guo, R."A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection". Oncology Letters 10.5 (2015): 2787-2794.
Chicago
Xiao, C., Wei, W., Guo, Z., Li, S., Zhang, Y., Wang, J., Shi, M., Guo, R."A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection". Oncology Letters 10, no. 5 (2015): 2787-2794. https://doi.org/10.3892/ol.2015.3677
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao C, Wei W, Guo Z, Li S, Zhang Y, Wang J, Shi M and Guo R: A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection. Oncol Lett 10: 2787-2794, 2015.
APA
Xiao, C., Wei, W., Guo, Z., Li, S., Zhang, Y., Wang, J. ... Guo, R. (2015). A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection. Oncology Letters, 10, 2787-2794. https://doi.org/10.3892/ol.2015.3677
MLA
Xiao, C., Wei, W., Guo, Z., Li, S., Zhang, Y., Wang, J., Shi, M., Guo, R."A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection". Oncology Letters 10.5 (2015): 2787-2794.
Chicago
Xiao, C., Wei, W., Guo, Z., Li, S., Zhang, Y., Wang, J., Shi, M., Guo, R."A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection". Oncology Letters 10, no. 5 (2015): 2787-2794. https://doi.org/10.3892/ol.2015.3677
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