Open Access

A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection

  • Authors:
    • Cheng-Zuo Xiao
    • Wei Wei
    • Zhi-Xing Guo
    • Shu-Hong Li
    • Yong-Fa Zhang
    • Jia-Hong Wang
    • Ming Shi
    • Rong-Ping Guo
  • View Affiliations

  • Published online on: September 3, 2015     https://doi.org/10.3892/ol.2015.3677
  • Pages: 2787-2794
  • Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to identify the risk factors influencing the survival of patients with hepatocellular carcinoma (HCC) affected by portal vein tumor thrombus (PVTT), following hepatic resection, and to establish a prognostic model. Between March 2001 and May 2008, 234 cases of HCC with PVTT that underwent hepatic resection were randomly divided into experimental or validation groups. The association between the clinicopathological factors and disease‑free survival (DFS) and overall survival (OS) was analyzed, and the significant factors involved were used to establish a prognostic model, which was then validated. Tumor rupture, number of tumors and macroscopic vascular invasion were observed to be independent risk factors of DFS and OS. In the prognostic model, the DFS and OS of low‑, medium‑ and high‑risk patients in the experimental group were observed to be significantly different, compared to those in the validation group. In conclusion, the present study established a prognostic model for patients with HCC affected by PVTT following hepatectomy, and demonstrated that the model may be used to guide the treatment of these patients and predict their prognosis.
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November-2015
Volume 10 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Xiao C, Wei W, Guo Z, Li S, Zhang Y, Wang J, Shi M and Guo R: A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection. Oncol Lett 10: 2787-2794, 2015
APA
Xiao, C., Wei, W., Guo, Z., Li, S., Zhang, Y., Wang, J. ... Guo, R. (2015). A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection. Oncology Letters, 10, 2787-2794. https://doi.org/10.3892/ol.2015.3677
MLA
Xiao, C., Wei, W., Guo, Z., Li, S., Zhang, Y., Wang, J., Shi, M., Guo, R."A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection". Oncology Letters 10.5 (2015): 2787-2794.
Chicago
Xiao, C., Wei, W., Guo, Z., Li, S., Zhang, Y., Wang, J., Shi, M., Guo, R."A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection". Oncology Letters 10, no. 5 (2015): 2787-2794. https://doi.org/10.3892/ol.2015.3677