Biliary papillomatosis with malignant transformation: A case report and review of the literature

Gu,Chichang; Lin,Ye; Jin,Haosheng; Jian,Zhixiang

doi:10.3892/ol.2015.3682

November-2015 Volume 10 Issue 5

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November-2015 Volume 10 Issue 5

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Case Report

Biliary papillomatosis with malignant transformation: A case report and review of the literature

Authors:
- Chichang Gu
- Ye Lin
- Haosheng Jin
- Zhixiang Jian
View Affiliations / Copyright

Affiliations: Second Department of General Surgery, Shunde First People's Hospital Affiliated to Southern Medical University, Foshan, Guangdong 528300, P.R. China, Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guaugzhou, Guangdong 510080, P.R. China
Pages: 3315-3317
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Published online on: September 8, 2015

https://doi.org/10.3892/ol.2015.3682
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Abstract

Biliary papillomatosis is a rare benign tumor that possesses a high potential for malignant transformation, and is frequently misdiagnosed. In the present report, a case of biliary papillomatosis with malignant transformation in a 63‑year‑old female, with a 19‑year history of cholelithiasis, is presented. The patient presented with right epigastric pain and magnetic resonance imaging revealed a diffuse mass in the right liver lobe, which extended through the common bile duct. Definitive preoperative diagnosis was unable to be established; however, following surgical resection of the tumor, a diagnosis of biliary papillomatosis with malignant transformation was confirmed by pathological examination. The patient was followed up seven months later and no recurrence was detected. A supplementary review of previously published literature is additionally presented.

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1	Nakajima T, Kondo Y, Miyazaki M and Okui K: A histopathologic study of 102 cases of intrahepatic cholangiocarcinoma: Histologic classification and modes of spreading. Hum Pathol. 19:1228–1234. 1988. View Article : Google Scholar : PubMed/NCBI
2	Nakanuma Y, Sasaki M, Ishikawa A, Tsui W, Chen TC and Huang SF: Biliary papillary neoplasm of the liver. Histol Histopathol. 17:851–861. 2002.PubMed/NCBI
3	Holtkamp W and Reis HE: Papillomatosis of the bile ducts: Papilloma-carcinoma sequence. Am J Gastroenterol. 89:2253–2255. 1994.PubMed/NCBI
4	Chappet V: Cancer epithelial primitif du canal cholédoque. Lyon Med. 76:145–157. 1894.
5	Sen I, Raju RS, Vyas FL, Eapen A and Sitaram V: Benign biliary papillomatosis in a patient with a choledochal cyst presenting as haemobilia: A case report. Ann R Coll Surg Engl. 94:e20–e21. 2012. View Article : Google Scholar : PubMed/NCBI
6	Neumann RD, LiVolsi VA, Rosenthal NS, Burrell M and Ball TJ: Adenocarcinoma in biliary papillomatosis. Gastroenterology. 70:779–782. 1976.PubMed/NCBI
7	Lee SS, Kim MH, Lee SK, Jang SJ, Song MH, Kim KP, Kim HJ, Seo DW, Song DE, Yu E, et al: Clinicopathologic review of 58 patients with biliary papillomatosis. Cancer. 100:783–793. 2004. View Article : Google Scholar : PubMed/NCBI
8	Jiang L, Yan LN, Jiang LS, Li FY, Ye H, Li N, Cheng NS and Zhou Y: Biliary papillomatosis: Analysis of 18 cases. Chin Med J (Engl). 121:2610–2612. 2008.PubMed/NCBI
9	Levy AD, Murakata LA, Abbott RM and Rohrmann CA Jr: Armed Forces Institute of Pathology: From the archives of the AFIP. Benign tumors and tumorlike lesions of the gallbladder and extrahepatic bile ducts: Radiologic-pathologic correlation. Radiographics. 22:387–413. 2002. View Article : Google Scholar : PubMed/NCBI
10	Hoang TV and Bluemke DA: Biliary papillomatosis: CT and MR findings. J Comput Assist Tomogr. 22:671–672. 1998. View Article : Google Scholar : PubMed/NCBI
11	Kim YS, Myung SJ, Kim SY, Kim HJ, Kim JS, Park ET, Lim BC, Seo DW, Lee SK, Kim MH, et al: Biliary papillomatosis: Clinical, cholangiographic and cholangioscopic findings. Endoscopy. 30:763–767. 1998. View Article : Google Scholar : PubMed/NCBI
12	Jiang L, Yan LN, Jiang LS, Li FY, Ye H, Li N, Cheng NS and Zhou Y: Biliary papillomatosis: Analysis of 18 cases. Chin Med J (Engl). 121:2610–2612. 2008.PubMed/NCBI
13	Imvrios G, Papanikolaou V, Lalountas M, Patsiaoura K, Giakoustidis D, Fouzas I, Anagnostara E, Antoniadis N and Takoudas D: Papillomatosis of intra- and extrahepatic biliary tree: Successful treatment with liver transplantation. Liver Transpl. 13:1045–1048. 2007. View Article : Google Scholar : PubMed/NCBI
14	Yeung YP, AhChong K, Chung CK and Chun AY: Biliary papillomatosis: Report of seven cases and review of English literature. J Hepatobiliary Pancreat Surg. 10:390–395. 2003. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Biliary papillomatosis with malignant transformation: A case report and review of the literature

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