Competing endogenous RNA: A novel posttranscriptional regulatory dimension associated with the progression of cancer (Review)

  • Authors:
    • Qingsong Dai
    • Jixia Li
    • Keyuan Zhou
    • Tong Liang
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  • Published online on: September 14, 2015     https://doi.org/10.3892/ol.2015.3698
  • Pages: 2683-2690
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Abstract

The existence of artificial sponges and antisense oligonucleotides designed to decrease the availability of microRNAs (miRNAs), a family of small non‑coding RNAs that target RNA transcripts through miRNA response elements (MREs) involved in gene expression, suggests that miRNAs may also be regulated. The wide range of RNA transcripts harboring MREs, termed competing endogenous RNAs (ceRNAs), includes protein‑coding messenger RNAs (mRNAs) and non‑coding RNAs, for example long non‑coding RNAs, pseudogenes and circular RNAs, which compete for a common pool of miRNAs as natural decoys. These ceRNAs are co‑regulated and produce large, complex posttranscriptional regulatory networks, which have been implicated in numerous biological processes. The present review discusses recent discoveries that implicate natural microRNA decoys in the development of cancer.
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November-2015
Volume 10 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Dai Q, Li J, Zhou K and Liang T: Competing endogenous RNA: A novel posttranscriptional regulatory dimension associated with the progression of cancer (Review). Oncol Lett 10: 2683-2690, 2015.
APA
Dai, Q., Li, J., Zhou, K., & Liang, T. (2015). Competing endogenous RNA: A novel posttranscriptional regulatory dimension associated with the progression of cancer (Review). Oncology Letters, 10, 2683-2690. https://doi.org/10.3892/ol.2015.3698
MLA
Dai, Q., Li, J., Zhou, K., Liang, T."Competing endogenous RNA: A novel posttranscriptional regulatory dimension associated with the progression of cancer (Review)". Oncology Letters 10.5 (2015): 2683-2690.
Chicago
Dai, Q., Li, J., Zhou, K., Liang, T."Competing endogenous RNA: A novel posttranscriptional regulatory dimension associated with the progression of cancer (Review)". Oncology Letters 10, no. 5 (2015): 2683-2690. https://doi.org/10.3892/ol.2015.3698