Radiation-induced hepatitis B virus reactivation in hepatocellular carcinoma: A case report

Cheng,Jun; Pei,Huan‑Huan; Sun,Juan; Xie,Qin‑Xiu; Li,Jia‑Bin

doi:10.3892/ol.2015.3724

November-2015 Volume 10 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

November-2015 Volume 10 Issue 5

Full Size Image

Case Report

Radiation-induced hepatitis B virus reactivation in hepatocellular carcinoma: A case report

Authors:
- Jun Cheng
- Huan‑Huan Pei
- Juan Sun
- Qin‑Xiu Xie
- Jia‑Bin Li
View Affiliations / Copyright

Affiliations: Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, Department of Science and Technology, Anhui University of Chinese Medicine, Hefei, Anhui 230038, P.R. China
Pages: 3213-3215
|
Published online on: September 18, 2015

https://doi.org/10.3892/ol.2015.3724
Expand metrics +

Abstract

Hepatitis B virus (HBV) reactivation associated with radiotherapy is rare. The present study reports the case of a 46‑year‑old man that experienced fatal HBV reactivation. The patient suffered from hepatocellular carcinoma (HCC) with portal vein tumor thrombus, which was treated by radiotherapy at a daily fraction of 2 Gy over 5 weeks, up to a total radiation dose of ~50 Gy. The patient presented with fatigue, yellow sclera and abdominal distension ~8 weeks subsequent to the administration of radiotherapy. The liver function tests, including the level of total bilirubin and prothrombin time, suggested acute‑on‑chronic liver failure. The serum HBV‑DNA level had also increased between undetectable levels and 7.2x104 copies/ml. Although the present patient with HCC was treated with 0.5 mg/day entecavir for 8 weeks, in addition to radiotherapy, radiation‑induced HBV reactivation occurred. The condition of the patient worsened gradually. The present study emphasizes the importance of liver function and HBV‑DNA screening and pre-emptive antiviral prophylaxis prior to radiotherapy in patients with HCC.

View Figures

View References

1	Lee WM: Hepatitis B virus infection. N Engl J Med. 337:1733–1745. 1997. View Article : Google Scholar : PubMed/NCBI
2	Lok AS: Chronic hepatitis B. N Engl J Med. 346:1682–1683. 2002. View Article : Google Scholar : PubMed/NCBI
3	Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK, Christensen E, Pagliaro L, Colombo M and Rodés J: EASL Panel of Experts on HCC: Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol. 35:421–430. 2001. View Article : Google Scholar : PubMed/NCBI
4	Jang JW, Kwon JH, You CR, Kim JD, Woo HY, Bae SH, Choi JY, Yoon SK and Chung KW: Risk of HBV reactivation according to viral status and treatment intensity in patients with hepatocellular carcinoma. Antivir Ther. 16:969–977. 2011. View Article : Google Scholar : PubMed/NCBI
5	Kang MK, Kim MS, Kim SK, Ye GW, Lee HJ, Kim TN and Eun JR: High-dose radiotherapy with intensity-modulated radiation therapy for advanced hepatocellular carcinoma. Tumori. 97:724–731. 2011.PubMed/NCBI
6	Yeo W and Johnson PJ: Diagnosis, prevention and management of hepatitis B virus reactivation during anticancer therapy. Hepatology. 43:209–220. 2006. View Article : Google Scholar : PubMed/NCBI
7	Yeo W, Lam KC, Zee B, Chan PS, Mo FK, Ho WM, Wong WL, Leung TW, Chan AT, Ma B, et al: Hepatitis B reactivation in patients with hepatocellular carcinoma undergoing systemic chemotherapy. Ann Oncol. 15:1661–1666. 2004. View Article : Google Scholar : PubMed/NCBI
8	Francisci D, Falcinelli F, Schiaroli E, Capponi M, Belfiori B, Flenghi L and Baldelli F: Management of hepatitis B virus reactivation in patients with hematological malignancies treated with chemotherapy. Infection. 38:58–61. 2010. View Article : Google Scholar : PubMed/NCBI
9	Kohrt HE, Ouyang DL and Keeffe EB: Systematic review: Lamivudine prophylaxis for chemotherapy-induced reactivation of chronic hepatitis B virus infection. Aliment Pharmacol Ther. 24:1003–1016. 2006. View Article : Google Scholar : PubMed/NCBI
10	Yeo W, Chan PK, Hui P, Ho WM, Lam KC, Kwan WH, Zhong S and Johnson PJ: Hepatitis B virus reactivation in breast cancer patients receiving cytotoxic chemotherapy: A prospective study. J Med Virol. 70:553–561. 2003. View Article : Google Scholar : PubMed/NCBI
11	Nagamatsu H, Kumashiro R, Itano S, Matsugaki S and Sata M: Investigation of associating factors in exacerbation of liver damage after chemotherapy in patients with HBV-related HCC. Hepatol Res. 26:293–301. 2003. View Article : Google Scholar : PubMed/NCBI
12	Lalazar G, Rund D and Shouval D: Screening, prevention and treatment of viral hepatitis B reactivation in patients with haematological malignancies. Br J Haematol. 136:699–712. 2007. View Article : Google Scholar : PubMed/NCBI
13	Chou CH, Chen PJ, Jeng YM, Cheng AL, Huang LR and Cheng JC: Synergistic effect of radiation and interleukin-6 on hepatitis B virus reactivation in liver through stat 3 signaling pathway. Int J Radiation Oncology Biol Phys. 75:1545–1552. 2009. View Article : Google Scholar
14	Huang W, Zhang W, Fan M, Lu Y, Zhang J, Li H and Li B: Risk factors for hepatitis B virus reactivation after conformal radiotherapy in patients with hepatocellular carcinoma. Cancer Sci. 105:697–703. 2014. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Radiation-induced hepatitis B virus reactivation in hepatocellular carcinoma: A case report

This article is mentioned in:

Abstract

Related Articles