Radiation-induced hepatitis B virus reactivation in hepatocellular carcinoma: A case report

  • Authors:
    • Jun Cheng
    • Huan‑Huan Pei
    • Juan Sun
    • Qin‑Xiu Xie
    • Jia‑Bin Li
  • View Affiliations

  • Published online on: September 18, 2015     https://doi.org/10.3892/ol.2015.3724
  • Pages: 3213-3215
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Abstract

Hepatitis B virus (HBV) reactivation associated with radiotherapy is rare. The present study reports the case of a 46‑year‑old man that experienced fatal HBV reactivation. The patient suffered from hepatocellular carcinoma (HCC) with portal vein tumor thrombus, which was treated by radiotherapy at a daily fraction of 2 Gy over 5 weeks, up to a total radiation dose of ~50 Gy. The patient presented with fatigue, yellow sclera and abdominal distension ~8 weeks subsequent to the administration of radiotherapy. The liver function tests, including the level of total bilirubin and prothrombin time, suggested acute‑on‑chronic liver failure. The serum HBV‑DNA level had also increased between undetectable levels and 7.2x104 copies/ml. Although the present patient with HCC was treated with 0.5 mg/day entecavir for 8 weeks, in addition to radiotherapy, radiation‑induced HBV reactivation occurred. The condition of the patient worsened gradually. The present study emphasizes the importance of liver function and HBV‑DNA screening and pre-emptive antiviral prophylaxis prior to radiotherapy in patients with HCC.
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November-2015
Volume 10 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Cheng J, Pei HH, Sun J, Xie QX and Li JB: Radiation-induced hepatitis B virus reactivation in hepatocellular carcinoma: A case report. Oncol Lett 10: 3213-3215, 2015
APA
Cheng, J., Pei, H., Sun, J., Xie, Q., & Li, J. (2015). Radiation-induced hepatitis B virus reactivation in hepatocellular carcinoma: A case report. Oncology Letters, 10, 3213-3215. https://doi.org/10.3892/ol.2015.3724
MLA
Cheng, J., Pei, H., Sun, J., Xie, Q., Li, J."Radiation-induced hepatitis B virus reactivation in hepatocellular carcinoma: A case report". Oncology Letters 10.5 (2015): 3213-3215.
Chicago
Cheng, J., Pei, H., Sun, J., Xie, Q., Li, J."Radiation-induced hepatitis B virus reactivation in hepatocellular carcinoma: A case report". Oncology Letters 10, no. 5 (2015): 3213-3215. https://doi.org/10.3892/ol.2015.3724