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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Reduced expression of sushi domain containing 2 is associated with progression of non-small cell lung cancer

  • Authors:
    • Cuixia Cai
    • Rong Shi
    • Yuan Gao
    • Jun Zeng
    • Min Wei
    • Handuo Wang
    • Wenling Zheng
    • Wenli Ma
  • View Affiliations / Copyright

    Affiliations: Institute of Genetic Engineering, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
  • Pages: 3619-3624
    |
    Published online on: September 23, 2015
       https://doi.org/10.3892/ol.2015.3737
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Abstract

Sushi domain containing 2 (SUSD2) has been identified as a gene encoding an 822-amino acid protein, which contains a transmembrane domain and functional domains inherent to adhesion molecules. Previous studies have reported that increased expression of SUSD2 has a critical role in tumorigenesis in human breast cancer. However, to the best of our knowledge, SUSD2 expression status and its correlation with the clinicopathological features of non‑small cell lung cancer (NSCLC) have not previously been investigated. In the present study, reverse transcription‑quantitative polymerase chain reaction and western blotting were used to evaluate SUSD2 messenger RNA (mRNA) and protein expression in NSCLC and adjacent normal lung tissues. The clinicopathological significance of SUSD2 was investigated by immunohistochemical analysis of an NSCLC tissue microarray. Receiver operating characteristic analysis was used to determine the cut‑off score for positive expression of SUSD2. Furthermore, the correlation between SUSD2 expression and the clinicopathological features of NSCLC was analyzed by χ2 test. The results revealed that SUSD2 mRNA (P<0.0001) and protein (P<0.0001) expression levels were significantly decreased in NSCLC tissues compared with those of adjacent normal tissues. When the SUSD2 positive expression percentage was determined to be >47.5% (area under ROC curve, 0.799; P<0.000), positive expression of SUSD2 was observed in 100% (32/32) of normal lung tissues and 55% (88/160) of NSCLC tissues by immunohistochemistry (χ2=21.160; P<0.000). Furthermore, it was demonstrated that the reduced SUSD2 protein levels in cancer tissues were positively correlated with poor histological grade (χ2=41.764; P<0.000), advanced clinical stage (χ2=10.790; P=0.013), higher pT (χ2=9.070; P=0.028) and positive regional lymph node metastasis (χ2=15.399; P=0.002). In conclusion, these data suggest that the reduced expression of SUSD2 is associated with the progression of NSCLC and may have a role in the pathogenesis of NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Cai C, Shi R, Gao Y, Zeng J, Wei M, Wang H, Zheng W and Ma W: Reduced expression of sushi domain containing 2 is associated with progression of non-small cell lung cancer. Oncol Lett 10: 3619-3624, 2015.
APA
Cai, C., Shi, R., Gao, Y., Zeng, J., Wei, M., Wang, H. ... Ma, W. (2015). Reduced expression of sushi domain containing 2 is associated with progression of non-small cell lung cancer. Oncology Letters, 10, 3619-3624. https://doi.org/10.3892/ol.2015.3737
MLA
Cai, C., Shi, R., Gao, Y., Zeng, J., Wei, M., Wang, H., Zheng, W., Ma, W."Reduced expression of sushi domain containing 2 is associated with progression of non-small cell lung cancer". Oncology Letters 10.6 (2015): 3619-3624.
Chicago
Cai, C., Shi, R., Gao, Y., Zeng, J., Wei, M., Wang, H., Zheng, W., Ma, W."Reduced expression of sushi domain containing 2 is associated with progression of non-small cell lung cancer". Oncology Letters 10, no. 6 (2015): 3619-3624. https://doi.org/10.3892/ol.2015.3737
Copy and paste a formatted citation
x
Spandidos Publications style
Cai C, Shi R, Gao Y, Zeng J, Wei M, Wang H, Zheng W and Ma W: Reduced expression of sushi domain containing 2 is associated with progression of non-small cell lung cancer. Oncol Lett 10: 3619-3624, 2015.
APA
Cai, C., Shi, R., Gao, Y., Zeng, J., Wei, M., Wang, H. ... Ma, W. (2015). Reduced expression of sushi domain containing 2 is associated with progression of non-small cell lung cancer. Oncology Letters, 10, 3619-3624. https://doi.org/10.3892/ol.2015.3737
MLA
Cai, C., Shi, R., Gao, Y., Zeng, J., Wei, M., Wang, H., Zheng, W., Ma, W."Reduced expression of sushi domain containing 2 is associated with progression of non-small cell lung cancer". Oncology Letters 10.6 (2015): 3619-3624.
Chicago
Cai, C., Shi, R., Gao, Y., Zeng, J., Wei, M., Wang, H., Zheng, W., Ma, W."Reduced expression of sushi domain containing 2 is associated with progression of non-small cell lung cancer". Oncology Letters 10, no. 6 (2015): 3619-3624. https://doi.org/10.3892/ol.2015.3737
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