Severe esophageal bleeding in colorectal cancer due to antitumor therapy: A case report

Shen,Hong; Ye,Xian‑Yun; Li,Xiao‑Fen; Pan,Wen‑Sheng; Yuan,Ying

doi:10.3892/ol.2015.3742

Severe esophageal bleeding in colorectal cancer due to antitumor therapy: A case report

Authors:
- Hong Shen
- Xian‑Yun Ye
- Xiao‑Fen Li
- Wen‑Sheng Pan
- Ying Yuan
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Affiliations: Department of Medical Oncology, Second Hospital of Zhejiang University College of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Gastroenterology, Second Hospital of Zhejiang University College of Medicine, Hangzhou, Zhejiang 310009, P.R. China
Published online on: September 24, 2015 https://doi.org/10.3892/ol.2015.3742
Pages: 3660-3662

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Abstract

Colorectal cancer is the third most common type of cancer worldwide, with >1 million cases diagnosed each year. Gastrointestinal bleeding is a common complication of colorectal cancer and is usually associated with the erosion and hemorrhage of the primary tumor. However, in patients who undergo a radical hemicolectomy and do not develop local recurrence, gastrointestinal bleeding may be a result of medical treatments or comorbidities. Esophageal bleeding in such patients is rare. Here, a case of severe esophageal bleeding due to anti‑angiogenesis therapy with bevacizumab, and chemotherapy with the FOLFIRI regimen (irinotecan, folinic acid and 5‑fluorouracil) in a patient with colorectal cancer is reported, and the possible pathogenesis of this event is analyzed based on the existing literature, in order to provide a reference for such cases.

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