Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2015 Volume 10 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2015 Volume 10 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Increased cyclin T1 expression as a favorable prognostic factor in treating gastric adenocarcinoma

  • Authors:
    • Jong‑Shiaw Jin
    • Lien‑Fu Lin
    • Jui‑Chang Chen
    • Chia‑Chi Huang
    • Jeng‑Horng Sheu
    • Wenlung Chen
    • Tang‑Yi Tsao
    • Chih‑Wei Hsu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Tungs' Taichung Metro Harbor Hospital, Taichung 43503, Taiwan, R.O.C., Division of Gastroenterology, Department of Internal Medicine, Tungs' Taichung Metro Harbor Hospital, Taichung 43503, Taiwan, R.O.C., Department of Applied Chemistry, National Chiayi University, Chia‑Yi 60004, Taiwan, R.O.C., Center of Nano Bio‑detection, National Chung Cheng University, Chia‑Yi 62102, Taiwan, R.O.C., Division of General Surgery, Department of Surgery, Tungs' Taichung Metro Harbor Hospital, Taichung 43503, Taiwan, R.O.C.
  • Pages: 3712-3718
    |
    Published online on: September 25, 2015
       https://doi.org/10.3892/ol.2015.3749
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The expression of cyclin A, B1, D1 and E in gastric adenocarcinoma is known to be associated with clinical outcome. However, few studies have investigated the role of cyclin T1 and cyclin‑dependent kinase 9 (CDK9) in gastric adenocarcinoma. Therefore, this study assessed the clinical significance of cyclin T1 and CDK9 expression in gastric adenocarcinoma. A total of 39 gastric adenocarcinoma patients received either radical total or distal gastrectomy in this study. Surgical tissue slides were stained with CDK9 and cyclin T1 antibodies, and immunohistochemistry scores and disease‑free survival (DFS) rates were analyzed. Among the 19 patients with tumor‑recurrent or distant metastasis, 16 were recorded as exhibiting low expression of cyclin T1. The remaining three patients exhibited high expression of the antibody. The results of patients with a higher T stage, N stage and tumor grade were less favorable. For patients with adenocarcinoma, the percentage of tissue slides stained with cyclin T1 was significantly higher than for those with normal stomach epithelia. The DFS rates of patients with low expression of cyclin T1 were significantly associated with poorer DFS rates. In conclusion, high expression of cyclin T1 is a favorable prognostic factor in treating patients with stomach adenocarcinoma.
View Figures

Figure 1

Figure 2

View References

1 

Ferlay J, Bray F, Pisani P and Parkin M: GLOBOCAN 2002: cancer incidence, mortality and prevalence worldwide. Lyon: IARC Press. 2004.

2 

Shah MA, Khanin R, Tang L, Janjigian YY, Klimstra DS, Gerdes H and Kelsen DP: Molecular classification of gastric cancer: a new paradigm. Clin Cancer Res. 17:2693–2701. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Moiola C, De Luca P, Gardner K, Vazquez E and De Siervi A: Cyclin T1 overexpression induces malignant transformation and tumor growth. Cell Cycle. 9:3119–3126. 2010. View Article : Google Scholar : PubMed/NCBI

4 

De Luca A, De Falco M, Baldi A and Paggi MG: Cyclin T: three forms for different roles in physiological and pathological functions. J Cell Physiol. 194:101–107. 2003. View Article : Google Scholar : PubMed/NCBI

5 

De Luca A, Russo P, Severino A, Baldi A, Battista T, Cavallotti I, De Luca L, Baldi F, Giordano A and Paggi MG: Pattern of expression of cyclin T1 in human tissues. J Histochem Cytochem. 49:685–692. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Sano M and Schneider MD: Cyclin-dependent kinase-9: an RNAPII kinase at the nexus of cardiac growth and death cascades. Circ Res. 95:867–876. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Sano M, Wang SC, Shirai M, Scaglia F, Xie M, Sakai S, Tanaka T, Kulkarni PA, Barger PM, Youker KA, et al: Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure. EMBO J. 23:3559–3569. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Chiu YL, Cao H, Jacque JM, Stevenson M and Rana TM: Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1). J Virol. 78:2517–2529. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Chao SH and Price DH: Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo. J Biol Chem. 276:31793–31799. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Napolitano G, Majello B and Lania L: Role of cyclinT/Cdk9 complex in basal and regulated transcription (review). Int J Oncol. 21:171–177. 2002.PubMed/NCBI

11 

Chen R, Keating MJ, Gandhi V and Plunkett W: Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death. Blood. 106:2513–2519. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Shan B, Zhuo Y, Chin D, Morris CA, Morris GF and Lasky JA: Cyclin-dependent kinase 9 is required for tumor necrosis factor-alpha-stimulated matrix metalloproteinase-9 expression in human lung adenocarcinoma cells. J Biol Chem. 280:1103–1011. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Sugai T, Tsukahara M, Endoh M, Shioi Y, Takebe N, Mue Y, Matsushita H, Toyota M and Suzuki K: Analysis of cell cycle-related proteins in gastric intramucosal differentiated-type cancers based on mucin phenotypes: a novel hypothesis of early gastric carcinogenesis based on mucin phenotype. BMC Gastroenterol. 10:552010. View Article : Google Scholar : PubMed/NCBI

14 

Ioachim E: Expression patterns of cyclins D1, E and cyclin-dependent kinase inhibitors p21waf1/cip1, p27kip1 in colorectal carcinoma: correlation with other cell cycle regulators (pRb, p53 and Ki-67 and PCNA) and clinicopathological features. Int J Clin Pract. 62:1736–1743. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Motohashi M, Wakui S, Muto T, Suzuki Y, Shirai M, Takahashi H and Hano H: Cyclin D1/cdk4, estrogen receptors α and β, in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric carcinogenesis: immunohistochemical study. J Toxicol Sci. 36:373–378. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Kouraklis G, Katsoulis IE, Theocharis S, Tsourouflis G, Xipolitas N, Glinavou A, Sioka C and Kostakis A: Does the expression of cyclin E, pRb and p21 correlate with prognosis in gastric adenocarcinoma? Dig Dis Sci. 54:1015–1020. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Li JQ, Miki H, Wu F, Saoo K, Nishioka M, Ohmori M and Imaida K: Cyclin A correlates with carcinogenesis and metastasis and p27(kip1) correlates with lymphatic invasion, in colorectal neoplasms. Hum Pathol. 33:1006–1015. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Mrena J, Wiksten JP, Kokkola A, Nordling S, Haglund C and Ristimäki A: Prognostic significance of cyclin A in gastric cancer. Int J Cancer. 119:1897–1901. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Yasuda M, Takesue F, Inutsuka S, Honda M, Nozoe T and Korenaga D: Overexpression of cyclin B1 in gastric cancer and its clinicopathological significance: an immunohistological study. J Cancer Res Clin Oncol. 128:412–416. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Washington K: 7th edition of the AJCC cancer staging manual: Stomach. Ann Surg Oncol. 17:3077–3079. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Berlth F, Bollschweiler E, Drebber U, Hoelscher AH and Moenig S: Pathohistological classification systems in gastric cancer: Diagnostic relevance and prognostic value. World J Gastroenterol. 20:5679–5684. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Leucci E, De Falco G, Onnis A, Cerino G, Cocco M, Luzzi A, Crupi D, Tigli C, Bellan C, Tosi P, et al: The role of the Cdk9/Cyclin T1 complex in T cell differentiation. J Cell Physiol. 212:411–415. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Bellan C, De Falco G, Lazzi S, Micheli P, Vicidomini S, Schürfeld K, Amato T, Palumbo A, Bagella L, Sabattini E, et al: CDK9/CYCLIN T1 expression during normal lymphoid differentiation and malignant transformation. J Pathol. 203:946–952. 2004. View Article : Google Scholar : PubMed/NCBI

24 

MacLachlan TK, Sang N, De Luca A, Puri PL, Levrero M and Giordano A: Binding of CDK9 to TRAF2. J Cell Biochem. 71:467–478. 1998. View Article : Google Scholar : PubMed/NCBI

25 

Fu TJ, Peng J, Lee G, Price DH and Flores O: Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription. J Biol Chem. 274:34527–34530. 1999. View Article : Google Scholar : PubMed/NCBI

26 

Bettayeb K, Tirado OM, Marionneau-Lambot S, Ferandin Y, Lozach O, Morris JC, Mateo-Lozano S, Drueckes P, Schächtele C, Kubbutat MH, et al: Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases. Cancer Res. 67:8325–8334. 2007. View Article : Google Scholar : PubMed/NCBI

27 

De Falco G and Giordano A: CDK9: From basal transcription to cancer and AIDS. Cancer Biol Ther. 1:342–377. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Lee DK, Duan HO and Chang C: Androgen receptor interacts with the positive elongation factor P-TEFb and enhances the efficiency of transcriptional elongation. J Biol Chem. 276:9978–9984. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Peng J, Zhu Y, Milton JT and Price DH: Identification of multiple cyclin subunits of human P-TEFb. Genes Dev. 12:755–762. 1998. View Article : Google Scholar : PubMed/NCBI

30 

Napolitano G, Majello B, Licciardo P, Giordano A and Lania L: Transcriptional activity of positive transcription elongation factor b kinase in vivo requires the C-terminal domain of RNA polymerase II. Gene. 254:139–145. 2000. View Article : Google Scholar : PubMed/NCBI

31 

Garriga J, Peng J, Parreño M, Price DH, Henderson EE and Graña X: Upregulation of cyclin T1/CDK9 complexes during T cell activation. Oncogene. 17:3093–3102. 1998. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jin JS, Lin LF, Chen JC, Huang CC, Sheu JH, Chen W, Tsao TY and Hsu CW: Increased cyclin T1 expression as a favorable prognostic factor in treating gastric adenocarcinoma. Oncol Lett 10: 3712-3718, 2015.
APA
Jin, J., Lin, L., Chen, J., Huang, C., Sheu, J., Chen, W. ... Hsu, C. (2015). Increased cyclin T1 expression as a favorable prognostic factor in treating gastric adenocarcinoma. Oncology Letters, 10, 3712-3718. https://doi.org/10.3892/ol.2015.3749
MLA
Jin, J., Lin, L., Chen, J., Huang, C., Sheu, J., Chen, W., Tsao, T., Hsu, C."Increased cyclin T1 expression as a favorable prognostic factor in treating gastric adenocarcinoma". Oncology Letters 10.6 (2015): 3712-3718.
Chicago
Jin, J., Lin, L., Chen, J., Huang, C., Sheu, J., Chen, W., Tsao, T., Hsu, C."Increased cyclin T1 expression as a favorable prognostic factor in treating gastric adenocarcinoma". Oncology Letters 10, no. 6 (2015): 3712-3718. https://doi.org/10.3892/ol.2015.3749
Copy and paste a formatted citation
x
Spandidos Publications style
Jin JS, Lin LF, Chen JC, Huang CC, Sheu JH, Chen W, Tsao TY and Hsu CW: Increased cyclin T1 expression as a favorable prognostic factor in treating gastric adenocarcinoma. Oncol Lett 10: 3712-3718, 2015.
APA
Jin, J., Lin, L., Chen, J., Huang, C., Sheu, J., Chen, W. ... Hsu, C. (2015). Increased cyclin T1 expression as a favorable prognostic factor in treating gastric adenocarcinoma. Oncology Letters, 10, 3712-3718. https://doi.org/10.3892/ol.2015.3749
MLA
Jin, J., Lin, L., Chen, J., Huang, C., Sheu, J., Chen, W., Tsao, T., Hsu, C."Increased cyclin T1 expression as a favorable prognostic factor in treating gastric adenocarcinoma". Oncology Letters 10.6 (2015): 3712-3718.
Chicago
Jin, J., Lin, L., Chen, J., Huang, C., Sheu, J., Chen, W., Tsao, T., Hsu, C."Increased cyclin T1 expression as a favorable prognostic factor in treating gastric adenocarcinoma". Oncology Letters 10, no. 6 (2015): 3712-3718. https://doi.org/10.3892/ol.2015.3749
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team