Choriocarcinoma with multiple lung, skull and skin metastases in a postmenopausal female: A case report

Li,Xiao‑Man; Liu,Xiao‑Yun; Liu,Zhi‑Xia

doi:10.3892/ol.2015.3750

December-2015 Volume 10 Issue 6

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

December-2015 Volume 10 Issue 6

Full Size Image

Case Report

Choriocarcinoma with multiple lung, skull and skin metastases in a postmenopausal female: A case report

Authors:
- Xiao‑Man Li
- Xiao‑Yun Liu
- Zhi‑Xia Liu
View Affiliations / Copyright

Affiliations: Department of Gynecology, The Third Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou 563000 P.R. China
Pages: 3837-3839
|
Published online on: September 25, 2015

https://doi.org/10.3892/ol.2015.3750
Expand metrics +

Abstract

Gestational trophoblastic disease with a primary extra‑uterine nidus is rare, particularly during the postmenopausal period. The present report outlines a case of high‑risk choriocarcinoma (International Federation of Gynecology and Obstetrics stage IV; World Health Organization score 13) in a 68‑year‑old female exhibiting neoplasm. The choriocarcinoma developed 20 years subsequent to the onset of menopause and 42 years following the patient's final pregnancy, and was associated with multiple metastases to the lungs, skull, neck, lymph nodes and skin. The patient was administered two courses of systemic chemotherapy with tegafur (800 mg) and actinomycin D (200 µg). Local chemotherapy was also administered to the scalp and left flank masses; the masses were injected first with methotrexate, and then with 5‑fluorouracil. During chemotherapy, the patient's levels of β-human chorionic gonadotrophin (β‑HCG) decreased from 3,171 IU/l to 1,763 IU/l, however by the conclusion of the courses of systemic and local chemotherapy, β‑HCG levels had increased to 3,704 IU/l. The patient and their family subsequently elected to end treatment. The patient subsequently succumbed to infection, tumor consumption and organ insufficiency. This study describes the clinical and radiological features, as well as the treatment used for this rare type of choriocarcinoma.

View Figures

View References

1	Morrow CP, Kletzky OA, Disaia PJ, Townsend DE, Mishell DR and Nakamura RM: Clinical and laboratory correlates of molar pregnancy and trophoblastic disease. Am J Obstet Gynecol. 128:424–430. 1977.PubMed/NCBI
2	Lee JH, Park CW, Chung DH and Kim WK: A case of lumbar metastasis of choriocarcinoma masquerading as an extraosseous extension of vertebral hemangioma. J Korean Neurosurg Soc. 47:143–147. 2010. View Article : Google Scholar : PubMed/NCBI
3	Cole LA, Khanlian SA, Muller CY, Giddings A, Kohorn E and Berkowitz R: Gestational trophoblastic disease: 3. Human chorionic gonadotrophin-free beta-subunit, reliable marker of placental site trophoblastic tumors. Gynecol Oncol. 102:160–164. 2006. View Article : Google Scholar : PubMed/NCBI
4	Sierra-Bergua B, Sánchez-Marteles M, Cabrerizo-García JL and Sanjoaquin-Conde I: Choriocarcinoma with pulmonary and cerebral metastases. Singapore Med J. 49:e286–e288. 2008.PubMed/NCBI
5	El-Helw LM and Hancock BW: Treatment of metastatic gestational trophoblastic neoplasia. Lancet Oncol. 8:715–724. 2007. View Article : Google Scholar : PubMed/NCBI
6	Morgan JM and Lurain JR: Gestational trophoblastic neoplasia: An update. Curr Oncol Rep. 10:497–504. 2008. View Article : Google Scholar : PubMed/NCBI
7	Guo J, Zhong C, Liu Q, Xu J, Zheng Y, Xu S, Gao Y, Guo Y, Wang Y, Luo Q and Jiang J: Intracranial choriocarcinoma occurrence in males: Two cases and a review of the literature. Oncol Lett. 6:1329–1332. 2013.PubMed/NCBI
8	Jacobs AJ, Newland JR and Green RK: Pure choriocarcinoma of the ovary. Obstet Gynecol Surv. 37:603–609. 1982. View Article : Google Scholar : PubMed/NCBI
9	Exman P, Takahashi TK, Gattás GF, Cantagalli VD, Anton C, Nalesso F and Diz Mdel P: Primary ovary choriocarcinoma: Individual DNA polymorphic analysis as a strategy to confirm diagnosis and treatment. Rare Tumors. 5:89–92. 2013. View Article : Google Scholar : PubMed/NCBI
10	Di Crescenzo V, Laperuta P, Napolitano F, Carlomagno C, Garzi A and Vitale M: An unusual case of primary choriocarcinoma of the lung. BMC Surg. 13(Suppl 2): S332013. View Article : Google Scholar : PubMed/NCBI
11	Gallagher L, Lind R and Oyasu R: Primary choriocarcinoma of the urinary bladder in association with undifferentiated carcinoma. Hum Pathol. 15:793–795. 1984. View Article : Google Scholar : PubMed/NCBI
12	Matsunaga N, Hayashi K, Futagawa S, Fukuda T, Takahara O, Yoshida K and Maeda H: Primary choriocarcinoma of the stomach presenting as gastrointestinal hemorrhage: Report of a case. Radiat Med. 7:220–222. 1989.PubMed/NCBI
13	Weiss S, Amit A, Schwartz MR and Kaplan AL: Primary choriocarcinoma of the vulva. Int J Gynecol Cancer. 11:251–254. 2001. View Article : Google Scholar : PubMed/NCBI
14	Milenković V, Lazović B, Mačvanski M, Jeremić K and Hrgović Z: Clinical outcome of a FIGO stage IV gestational choriocarcinoma. Case Rep Oncol. 6:504–507. 2013. View Article : Google Scholar : PubMed/NCBI
15	Singh S, Sardhana M, Sharma S and Chitralkar P: Choriocarcinoma presenting as an isolated bone marrow metastasis - a case report. Ecancermedicalscience. 8:3932014.PubMed/NCBI
16	FIGO Committee on Gynecologic Oncology: Current FIGO staging for cancer of the vagina, fallopian tube, ovary, and gestational trophoblastic neoplasia. Int J Gynaecol Obstet. 105:3–4. 2009. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Choriocarcinoma with multiple lung, skull and skin metastases in a postmenopausal female: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Related Articles