An invasive mole with bilateral kidney metastases: A case report

Yao,Kun; Gan,Yu; Tang,Yuxin; Tang,Jin; He,Leye; Dai,Yingbo

doi:10.3892/ol.2015.3768

An invasive mole with bilateral kidney metastases: A case report

Authors:
- Kun Yao
- Yu Gan
- Yuxin Tang
- Jin Tang
- Leye He
- Yingbo Dai
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Affiliations: Department of Urology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China
Published online on: September 29, 2015 https://doi.org/10.3892/ol.2015.3768
Pages: 3407-3410
Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Clinical reports of kidney metastases derived from an invasive mole (IM) are rare. The present study presents the case of a 42‑year‑old woman who exhibited IM and bilateral kidneys metastases in what may be, to the best of our knowledge, the first report of such a case. Following an induced abortion, the patient initially experienced irregular vaginal bleeding and subsequently presented with left‑sided waist and abdominal pain. The patient was admitted to hospital and was clinically diagnosed with gestational trophoblastic neoplasia (GTN), as well as bilateral kidney metastases and a spontaneous rupture of the left kidney. This diagnosis was based on the patient's medical history, which comprised increased levels of human chorionic gonadotropin β and aberrant results on computed tomography (CT) scans. The patient subsequently received conservative management to prevent renal damage, and a standard etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine chemotherapy regimen for GTN was administered. Following eight cycles of chemotherapy, a follow‑up CT examination indicated that the damage in the patient's left kidney could not be corrected with conservative treatments, therefore the left kidney was excised and a laparoscopic hysterectomy was performed. The pathological results were consistent with the clinical diagnosis and allowed further classification of the primary tumor as an IM. The present case demonstrated that it is possible for IM to metastasize to the kidney, and furthermore, that this type of metastatic tumor may be fragile and possess the potential to cause spontaneous kidney rupture.

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