Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging

  • Authors:
    • Jing Lei
    • Qian Han
    • Shaocheng Zhu
    • Dapeng Shi
    • Shewei Dou
    • Zihua Su
    • Xiao Xu
  • View Affiliations

  • Published online on: October 5, 2015     https://doi.org/10.3892/ol.2015.3779
  • Pages: 3607-3612
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Abstract

The aim of the present study was to investigate whether quantitative dynamic contrast‑enhanced magnetic resonance imaging (DCE-MRI) can predict an early response in primary esophageal carcinoma patients undergoing concurrent chemoradiotherapy. A total of 25 patients with who were pathologically confirmed stage II-III esophageal carcinoma underwent quantitative DCE-MRI prior to chemoradiotherapy, and at 3 weeks post-treatment, the quantitative parameters [Ktrans (volume transfer constant; the rate at which contrast agent distributes from the plasma to the EES), Kep (rate contrast; the rate at which the contrast agent that has diffused to the EES returns to the plasma) and Ve (the contrast agent percentage in the space of the extracellular fluid)] were analyzed respectively. The 25 cases were categorized as a complete response (CR) or a partial response (PR). An independent samples Mann‑Whitney U test was used to compare the quantitative parameters between CR and PR. A receiver operating characteristic curve (ROC) was used to determine the best predictor. In total, 17 patients were in the CR group and 8 patients were in the PR group. Pretreatment Ktrans, Kep and Ve values were 0.54±0.17/min, 1.12±0.46/min and 0.37±0.14, respectively, in the CR group, and 0.40±0.21/min, 1.07±0.37/min and 0.40±0.22, respectively, in the PR group. There was a significant difference between the two groups for Ktrans, but there were no significant differences between the two groups for Kep and Ve. The Ktrans, Kep and Ve values at 3 weeks post‑treatment were 0.33±0.11/min, 0.86±0.31/min and 0.66±0.05, respectively, in the CR group, and 0.62±0.22/min, 1.19±0.39/min and 0.45±0.19, respectively, in the PR group. The corresponding U values were ‑3.319, ‑1.719 and ‑2.628, respectively, and the P‑values were 0.006, 0.119 and 0.021, respectively. The areas under the ROC curve of Ktrans prior to chemoradiotherapy, and of Ktrans and Kep at 3 weeks post‑treatment were 0.648, 0.741 and 0.796, respectively. In conclusion, DCE‑MRI can predict an early response in primary esophageal carcinoma following 3 weeks of concurrent chemoradiotherapy. Ktrans prior to chemoradiotherapy, and Ktrans and Kep at 3 weeks post-treatment are sensitive prediction parameters.
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December-2015
Volume 10 Issue 6

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Online ISSN:1792-1082

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Spandidos Publications style
Lei J, Han Q, Zhu S, Shi D, Dou S, Su Z and Xu X: Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging. Oncol Lett 10: 3607-3612, 2015
APA
Lei, J., Han, Q., Zhu, S., Shi, D., Dou, S., Su, Z., & Xu, X. (2015). Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging. Oncology Letters, 10, 3607-3612. https://doi.org/10.3892/ol.2015.3779
MLA
Lei, J., Han, Q., Zhu, S., Shi, D., Dou, S., Su, Z., Xu, X."Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging". Oncology Letters 10.6 (2015): 3607-3612.
Chicago
Lei, J., Han, Q., Zhu, S., Shi, D., Dou, S., Su, Z., Xu, X."Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging". Oncology Letters 10, no. 6 (2015): 3607-3612. https://doi.org/10.3892/ol.2015.3779