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Article

Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging

  • Authors:
    • Jing Lei
    • Qian Han
    • Shaocheng Zhu
    • Dapeng Shi
    • Shewei Dou
    • Zihua Su
    • Xiao Xu
  • View Affiliations / Copyright

    Affiliations: Graduate School, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China, Department of Radiology, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China, Department of Premium Application, GE Healthcare Life Sciences, Beijing 100176, P.R. China
  • Pages: 3607-3612
    |
    Published online on: October 5, 2015
       https://doi.org/10.3892/ol.2015.3779
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Abstract

The aim of the present study was to investigate whether quantitative dynamic contrast‑enhanced magnetic resonance imaging (DCE-MRI) can predict an early response in primary esophageal carcinoma patients undergoing concurrent chemoradiotherapy. A total of 25 patients with who were pathologically confirmed stage II-III esophageal carcinoma underwent quantitative DCE-MRI prior to chemoradiotherapy, and at 3 weeks post-treatment, the quantitative parameters [Ktrans (volume transfer constant; the rate at which contrast agent distributes from the plasma to the EES), Kep (rate contrast; the rate at which the contrast agent that has diffused to the EES returns to the plasma) and Ve (the contrast agent percentage in the space of the extracellular fluid)] were analyzed respectively. The 25 cases were categorized as a complete response (CR) or a partial response (PR). An independent samples Mann‑Whitney U test was used to compare the quantitative parameters between CR and PR. A receiver operating characteristic curve (ROC) was used to determine the best predictor. In total, 17 patients were in the CR group and 8 patients were in the PR group. Pretreatment Ktrans, Kep and Ve values were 0.54±0.17/min, 1.12±0.46/min and 0.37±0.14, respectively, in the CR group, and 0.40±0.21/min, 1.07±0.37/min and 0.40±0.22, respectively, in the PR group. There was a significant difference between the two groups for Ktrans, but there were no significant differences between the two groups for Kep and Ve. The Ktrans, Kep and Ve values at 3 weeks post‑treatment were 0.33±0.11/min, 0.86±0.31/min and 0.66±0.05, respectively, in the CR group, and 0.62±0.22/min, 1.19±0.39/min and 0.45±0.19, respectively, in the PR group. The corresponding U values were ‑3.319, ‑1.719 and ‑2.628, respectively, and the P‑values were 0.006, 0.119 and 0.021, respectively. The areas under the ROC curve of Ktrans prior to chemoradiotherapy, and of Ktrans and Kep at 3 weeks post‑treatment were 0.648, 0.741 and 0.796, respectively. In conclusion, DCE‑MRI can predict an early response in primary esophageal carcinoma following 3 weeks of concurrent chemoradiotherapy. Ktrans prior to chemoradiotherapy, and Ktrans and Kep at 3 weeks post-treatment are sensitive prediction parameters.
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1 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Domper Arnal MJ, Ferrández Arenas Á and Lanas Arbeloa Á: Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries. World J Gastroenterol. 21:7933–7943. 2015.PubMed/NCBI

3 

He J and Shao K: The epidemiology, current status of management, challenge and future strategy for esophageal cancer in China. Zhong Guo Ai Zheng Za Zhi. 21:501–504. 2011.(In Chinese).

4 

Haefner MF, Lang K, Krug D, Koerber SA, Uhlmann L, Kieser M, Debus J and Sterzing F: Prognostic factors, patterns of recurrence and toxicity for patients with esophageal cancer undergoing definitive radiotherapy or chemo-radiotherapy. J Radiat Res. 56:742–749. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Wong RK and Malthaner R: Withdrawn. Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus. Cochrane Database Syst Rev. 1:CD0020922010.PubMed/NCBI

6 

Lu WB, Yu JP, Ni XC, Wang J, Jin JH, Deng LH, Deng JZ, Sun ZQ and Sun SP: Relation between tumor pathologic response to concurrent chemo-radiotherapy and changes of serum VEGF level and its influence on the efficacy and prognosis in patients with esophageal carcinoma. Zhong Hua Fang She Yi Xue Yu Fang Hu Za Zhi. 33:299–302. 2013.(In Chinese).

7 

Beierle EA, Strande LF and Chen MK: VEGF upregulates Bcl-2 expression and is associated with decreased apoptosis in neuroblastoma cells. J Pediatr Surg. 37:467–471. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Tofts PS, Brix G, Buckley DL, Evelhoch JL, Henderson E, Knopp MV, Larsson HB, Lee TY, Mayr NA, Parker GJ, et al: Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: Standardized quantities and symbols. J Magn Reson Imaging. 10:223–232. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Oberholzer K, Pohlmann A, Schreiber W, Mildenberger P, Kunz P, Schmidberger H, Junginger T and Düber C: Assessment of tumor microcirculation with dynamic contrast-enhanced MRI in patients with esophageal cancer: Initial experience. J Magn Reson Imaging. 27:1296–1301. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Cortés González R and Villaseñor Caloca R: Esophageal cancer. Rev Gastroenterol Mex. 62:149–159. 1997.(In Spanish). PubMed/NCBI

12 

Greer SE, Goodney PP, Sutton JE and Birkmeyer JD: Neoadjuvant chemoradiotherapy for esophageal carcinoma: A meta-analysis. Surgery. 137:172–177. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Al-Sarraf M, Martz K, Herskovic A, Leichman L, Brindle JS, Vaitkevicius VK, Cooper J, Byhardt R, Davis L and Emami B: Progress report of combined chemoradiotherapy versus radiotherapy alone in patients with esophageal cancer: An intergroup study. J Clin Oncol. 15:277–284. 1997.PubMed/NCBI

14 

Yoon DH, Jang G, Kim JH, Kim YH, Kim JY, Kim HR, Jung HY, Lee GH, Song HY, Cho KJ, et al: Randomized phase 2 trial of S1 and oxaliplatin-based chemoradiotherapy with or without induction chemotherapy for esophageal cancer. Int J Radiat Oncol Biol Phys. 91:489–496. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Shin SU, Lee JM, Yu MH, Yoon JH, Han JK, Choi BI, Glaser KJ and Ehman RL: Prediction of esophageal varices in patients with cirrhosis: Usefulness of three-dimensional MR elastography with echo-planar imaging technique. Radiology. 272:143–153. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Jia ZZ, Zhang J, Tang WJ, Wu XH, Gu HM, Geng DY and Chen XR: Assessing the microvascular permeability of brain glioma by DCE-MRI. Zhong Guo Yi Xue Ji Suan Ji Cheng Xiang Za Zhi. 19:293–297. 2013.(In Chinese).

17 

Esposito A, Palmisano A, Maffi P, Malosio ML, Nano R, Canu T, De Cobelli F, Piemonti L, Ironi G, Secchi A and Del Maschio A: Liver perfusion changes occurring during pancreatic islet engraftment: A dynamic contrast-enhanced magnetic resonance study. Am J Transplant. 14:202–209. 2014. View Article : Google Scholar : PubMed/NCBI

18 

He W, Liu Y, Liu JY and Lu M: Prostate cancer: Diagnostic value of quantitative analysis by dynamic contrast-enhanced MR at 3.0 T. Zhong Hua Fang She Xue Za Zhi. 48:215–218. 2014.(In Chinese).

19 

Zhao LY, Zhang RZ, Zhou CW, Li J and Wang L: Quantitative dynamic contrast enhanced MR in the prediction of response in breast cancer patients undergoing neoadjuvant chemotherapy. Zhong Hua Fang She Xue Za Zhi. 47:704–708. 2013.(In Chinese).

20 

Chang EY, Li X, Jerosch-Herold M, Priest RA, Enestvedt CK, Xu J, Springer CS Jr and Jobe BA: The evaluation of esophageal adenocarcinoma using dynamic contrast-enhanced magnetic resonance imaging. J Gastrointest Surg. 12:166–175. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Padhani AR, Hayes C, Assersohn L, Powles T, Makris A, Suckling J, Leach MO and Husband JE: Prediction of clinicopathologic response of breast cancer to primary chemotherapy at contrast-enhanced MR imaging: Initial clinical results. Radiology. 239:361–374. 2006. View Article : Google Scholar : PubMed/NCBI

22 

George ML, Dzik-Jurasz AS, Padhani AR, Brown G, Tait DM, Eccles SA and Swift RI: Non-invasive methods of assessing angiogenesis and their value in predicting response to treatment in colorectal cancer. Br J Surg. 88:1628–1636. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Akisik MF, Sandrasegaran K, Bu G, Lin C, Hutchins GD and Chiorean EG: Pancreatic cancer: Utility of dynamic contrast-enhanced MR imaging in assessment of antiangiogenic therapy. Radiology. 256:441–449. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Hahn OM, Yang C, Medved M, Karczmar G, Kistner E, Karrison T, Manchen E, Mitchell M, Ratain MJ and Stadler WM: Dynamic contrast-enhanced magnetic resonance imaging pharmacodynamic biomarker study of sorafenib in metastatic renal carcinoma. J Clin Oncol. 26:4572–4578. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lei J, Han Q, Zhu S, Shi D, Dou S, Su Z and Xu X: Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging. Oncol Lett 10: 3607-3612, 2015.
APA
Lei, J., Han, Q., Zhu, S., Shi, D., Dou, S., Su, Z., & Xu, X. (2015). Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging. Oncology Letters, 10, 3607-3612. https://doi.org/10.3892/ol.2015.3779
MLA
Lei, J., Han, Q., Zhu, S., Shi, D., Dou, S., Su, Z., Xu, X."Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging". Oncology Letters 10.6 (2015): 3607-3612.
Chicago
Lei, J., Han, Q., Zhu, S., Shi, D., Dou, S., Su, Z., Xu, X."Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging". Oncology Letters 10, no. 6 (2015): 3607-3612. https://doi.org/10.3892/ol.2015.3779
Copy and paste a formatted citation
x
Spandidos Publications style
Lei J, Han Q, Zhu S, Shi D, Dou S, Su Z and Xu X: Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging. Oncol Lett 10: 3607-3612, 2015.
APA
Lei, J., Han, Q., Zhu, S., Shi, D., Dou, S., Su, Z., & Xu, X. (2015). Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging. Oncology Letters, 10, 3607-3612. https://doi.org/10.3892/ol.2015.3779
MLA
Lei, J., Han, Q., Zhu, S., Shi, D., Dou, S., Su, Z., Xu, X."Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging". Oncology Letters 10.6 (2015): 3607-3612.
Chicago
Lei, J., Han, Q., Zhu, S., Shi, D., Dou, S., Su, Z., Xu, X."Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging". Oncology Letters 10, no. 6 (2015): 3607-3612. https://doi.org/10.3892/ol.2015.3779
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