Tyrphostin AG 1296 induces glioblastoma cell apoptosis in vitro and in vivo

Li,Hongwei; Zheng,Junning; Guan,Ruiyun; Zhu,Zifeng; Yuan,Xianhou

doi:10.3892/ol.2015.3781

December-2015 Volume 10 Issue 6

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December-2015 Volume 10 Issue 6

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Article Open Access

Tyrphostin AG 1296 induces glioblastoma cell apoptosis in vitro and in vivo

Authors:
- Hongwei Li
- Junning Zheng
- Ruiyun Guan
- Zifeng Zhu
- Xianhou Yuan
View Affiliations / Copyright

Affiliations: Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Neurosurgery, The Eight People's Hospital of Shenzhen, Shenzhen, Guangdong 510000, P.R. China

Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 3429-3433
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Published online on: October 6, 2015

https://doi.org/10.3892/ol.2015.3781
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Abstract

Glioblastoma is the most common type of malignant human brain tumor. Currently available chemotherapies for glioblastoma focus on targeting tyrosine kinases. However, the existing inhibitors of tyrosine kinases have not produced the therapeutic outcomes that were anticipated. In order to investigate the viability alternative chemotherapeutic agents in this disease, the present study examined the anticancer effects of tyrphostin AG 1296, focusing on its involvement in apoptosis in glioblastoma cells. The study aimed to identify whether tyrphostin AG 1296 affects glioblastoma cell growth by inducing cell apoptosis. To achieve this, cell viability, propidium iodide analysis and cell invasion assay were used to measure cell growth, cell apoptosis and cell migration of human glioblastoma cells. The results showed that tyrphostin AG 1296 treatment reduced cell viability and suppressed migration of human glioblastoma cells. It was also demonstrated that tyrphostin AG 1296 induced cell apoptosis in vitro. Finally, tyrphostin AG 1296 was also shown to significantly inhibit the growth of glioblastoma cells and to increase tumor cell apoptosis in vivo. These findings suggest that tyrphostin AG 1296 induces apoptosis, thereby reducing cell viability and capacity for migration of glioblastoma cells.

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