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Article Open Access

Mean platelet volume predicts chemotherapy response and prognosis in patients with unresectable gastric cancer

  • Authors:
    • Lian Lian
    • You‑You Xia
    • Chong Zhou
    • Xiao‑Ming Shen
    • Xiang‑Li Li
    • Shu‑Guang Han
    • Yan Zheng
    • Fei‑Ran Gong
    • Min Tao
    • Wei Li
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Radiation Oncology, Lianyungang First People's Hospital, Lianyungang, Jiangsu 222002, P.R. China, Department of Radiation Oncology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China, Department of Oncology, Suzhou Xiangcheng People's Hospital, Suzhou, Jiangsu 215131, P.R. China, Department of General Surgery, Suzhou Xiangcheng People's Hospital, Suzhou, Jiangsu 215133, P.R. China, Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
    Copyright: © Lian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3419-3424
    |
    Published online on: October 8, 2015
       https://doi.org/10.3892/ol.2015.3784
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Abstract

Gastric cancer is the fourth most frequent cancer and the second cause of cancer-related mortalities worldwide. Platelets play an important and multifaceted role in cancer progression. Elevated mean platelet volume (MPV) detected in peripheral blood has been identified in various types of cancer. In the present study, we investigated the application value of MPV in the prediction of chemotherapy response and prognosis in patients with unresectable gastric cancer. A total of 128 patients with unresectable gastric cancer were included and divided according to the median values of baseline MPV (low MPV: <11.65 or high MPV: ≥11.65). A low baseline MPV level was correlated with reduced metastasis. The results showed that patients with a low baseline level of MPV improved response to chemotherapy. Changes in MPV were associated with therapeutic efficacy. Patients who remained in or were transferred into the low MPV level subgroup following first‑line chemotherapy had improved response, compared to those remaining in or being transferred into the high MPV level group. The patients with a higher baseline MPV had decreased progression‑free and overall survival ratios. Univariate and multivariate analyses revealed that baseline MPV was a prognostic factor affecting progression‑free survival. In conclusion, the results showed that MPV measurements can provide important prognostic information for gastric cancer patients.
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Copy and paste a formatted citation
Spandidos Publications style
Lian L, Xia YY, Zhou C, Shen XM, Li XL, Han SG, Zheng Y, Gong FR, Tao M, Li W, Li W, et al: Mean platelet volume predicts chemotherapy response and prognosis in patients with unresectable gastric cancer. Oncol Lett 10: 3419-3424, 2015.
APA
Lian, L., Xia, Y., Zhou, C., Shen, X., Li, X., Han, S. ... Li, W. (2015). Mean platelet volume predicts chemotherapy response and prognosis in patients with unresectable gastric cancer. Oncology Letters, 10, 3419-3424. https://doi.org/10.3892/ol.2015.3784
MLA
Lian, L., Xia, Y., Zhou, C., Shen, X., Li, X., Han, S., Zheng, Y., Gong, F., Tao, M., Li, W."Mean platelet volume predicts chemotherapy response and prognosis in patients with unresectable gastric cancer". Oncology Letters 10.6 (2015): 3419-3424.
Chicago
Lian, L., Xia, Y., Zhou, C., Shen, X., Li, X., Han, S., Zheng, Y., Gong, F., Tao, M., Li, W."Mean platelet volume predicts chemotherapy response and prognosis in patients with unresectable gastric cancer". Oncology Letters 10, no. 6 (2015): 3419-3424. https://doi.org/10.3892/ol.2015.3784
Copy and paste a formatted citation
x
Spandidos Publications style
Lian L, Xia YY, Zhou C, Shen XM, Li XL, Han SG, Zheng Y, Gong FR, Tao M, Li W, Li W, et al: Mean platelet volume predicts chemotherapy response and prognosis in patients with unresectable gastric cancer. Oncol Lett 10: 3419-3424, 2015.
APA
Lian, L., Xia, Y., Zhou, C., Shen, X., Li, X., Han, S. ... Li, W. (2015). Mean platelet volume predicts chemotherapy response and prognosis in patients with unresectable gastric cancer. Oncology Letters, 10, 3419-3424. https://doi.org/10.3892/ol.2015.3784
MLA
Lian, L., Xia, Y., Zhou, C., Shen, X., Li, X., Han, S., Zheng, Y., Gong, F., Tao, M., Li, W."Mean platelet volume predicts chemotherapy response and prognosis in patients with unresectable gastric cancer". Oncology Letters 10.6 (2015): 3419-3424.
Chicago
Lian, L., Xia, Y., Zhou, C., Shen, X., Li, X., Han, S., Zheng, Y., Gong, F., Tao, M., Li, W."Mean platelet volume predicts chemotherapy response and prognosis in patients with unresectable gastric cancer". Oncology Letters 10, no. 6 (2015): 3419-3424. https://doi.org/10.3892/ol.2015.3784
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