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Review

Targeting Bruton's tyrosine kinase signaling as an emerging therapeutic agent of B‑cell malignancies (Review)

  • Authors:
    • Bing Xia
    • Fulian Qu
    • Tian Yuan
    • Yizhuo Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, P.R. China
  • Pages: 3339-3344
    |
    Published online on: October 13, 2015
       https://doi.org/10.3892/ol.2015.3802
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Abstract

It is becoming increasingly evident that B‑cell receptor (BCR) signaling is central to the development and function of B cells. BCR signaling has emerged as a pivotal pathway and a key driver of numerous B‑cell lymphomas. Disruption of BCR signaling can be lethal to malignant B cells. Recently, kinase inhibitors that target BCR signaling have induced notable clinical responses. These inhibitors include spleen tyrosine kinase, mammalian target of rapamycin, phosphoinositide 3'‑kinase and Bruton's tyrosine kinase (BTK). Ibrutinib, an oral irreversible BTK inhibitor, has emerged as a promising targeted therapy for patients with B‑cell malignancies. The present review discusses the current understanding of BTK‑mediated BCR signaling in the biology and pathobiology of normal and malignant B cells, and the cellular interaction with the tumor microenvironment. The data on ibrutinib in the preclinical and clinical settings is also discussed, and perspectives for the future use of ibrutinib are outlined.
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Copy and paste a formatted citation
Spandidos Publications style
Xia B, Qu F, Yuan T and Zhang Y: Targeting Bruton's tyrosine kinase signaling as an emerging therapeutic agent of B‑cell malignancies (Review). Oncol Lett 10: 3339-3344, 2015.
APA
Xia, B., Qu, F., Yuan, T., & Zhang, Y. (2015). Targeting Bruton's tyrosine kinase signaling as an emerging therapeutic agent of B‑cell malignancies (Review). Oncology Letters, 10, 3339-3344. https://doi.org/10.3892/ol.2015.3802
MLA
Xia, B., Qu, F., Yuan, T., Zhang, Y."Targeting Bruton's tyrosine kinase signaling as an emerging therapeutic agent of B‑cell malignancies (Review)". Oncology Letters 10.6 (2015): 3339-3344.
Chicago
Xia, B., Qu, F., Yuan, T., Zhang, Y."Targeting Bruton's tyrosine kinase signaling as an emerging therapeutic agent of B‑cell malignancies (Review)". Oncology Letters 10, no. 6 (2015): 3339-3344. https://doi.org/10.3892/ol.2015.3802
Copy and paste a formatted citation
x
Spandidos Publications style
Xia B, Qu F, Yuan T and Zhang Y: Targeting Bruton's tyrosine kinase signaling as an emerging therapeutic agent of B‑cell malignancies (Review). Oncol Lett 10: 3339-3344, 2015.
APA
Xia, B., Qu, F., Yuan, T., & Zhang, Y. (2015). Targeting Bruton's tyrosine kinase signaling as an emerging therapeutic agent of B‑cell malignancies (Review). Oncology Letters, 10, 3339-3344. https://doi.org/10.3892/ol.2015.3802
MLA
Xia, B., Qu, F., Yuan, T., Zhang, Y."Targeting Bruton's tyrosine kinase signaling as an emerging therapeutic agent of B‑cell malignancies (Review)". Oncology Letters 10.6 (2015): 3339-3344.
Chicago
Xia, B., Qu, F., Yuan, T., Zhang, Y."Targeting Bruton's tyrosine kinase signaling as an emerging therapeutic agent of B‑cell malignancies (Review)". Oncology Letters 10, no. 6 (2015): 3339-3344. https://doi.org/10.3892/ol.2015.3802
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