Painful neuropathy in a diabetic patient resulting from lung cancer and not diabetes: A case report

Yao,He‑Bin; Chen,Ya‑Ning; Shang,Jian; Han,Qiao‑Jun

doi:10.3892/ol.2015.3808

Painful neuropathy in a diabetic patient resulting from lung cancer and not diabetes: A case report

Authors:
- He‑Bin Yao
- Ya‑Ning Chen
- Jian Shang
- Qiao‑Jun Han
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Affiliations: Department of Endocrinology, Chinese People's Liberation Army Navy General Hospital, Beijing 100048, P.R. China
Published online on: October 15, 2015 https://doi.org/10.3892/ol.2015.3808
Pages: 3850-3852

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Abstract

The current study reports the case of a 61‑year‑old man with diabetes who was suffering from generalized pain over the whole body and gradually progressive numbness. The patient was initially diagnosed with diabetic peripheral neuropathy and received treatment, however, the symptoms persisted. In October 2010, the patient was admitted to the Chinese People's Liberation Army Navy General Hospital (Beijing, China) for the treatment of diabetes, however, a full‑body sharp pain was also described, which was relieved upon massaging the area. Causes, other than diabetes, were investigated for these symptoms. Chest computed tomography and positron emission tomography‑computed tomography scans revealed a mass shadow in the right lower lobe of the lung, with multiple lymphatic metastases. Lung cancer was diagnosed with a tumor‑node‑metastasis stage of T1N3Mx. Following treatment of the cancer with chemotherapy and radiotherapy, the patient's symptoms were significantly improved. The present study reports a rare case of a paraneoplastic neurological syndrome (PNS) that presented as painful neuropathy resulting from lung cancer, which mimicked diabetic peripheral neuropathy.

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1	Guariguata L, Whiting D, Hambleton I, Beagley J, Linnenkamp U and Shaw J: Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 103:137–149. 2014. View Article : Google Scholar : PubMed/NCBI
2	Vinik AI and Casellini CM: Guidelines in the management of diabetic nerve pain: Clinical utility of pregabalin. Diabetes Metab Syndr Obes. 6:57–78. 2013. View Article : Google Scholar : PubMed/NCBI
3	Hartemann A, Attal N, Bouhassira D, Dumont I, Gin H, Jeanne S, Said G and Richard JL: Working Group on the Diabetic Foot from the French-speaking Society of Diabetology: Painful diabetic neuropathy: Diagnosis and management. Diabetes Metab. 37:377–388. 2011. View Article : Google Scholar : PubMed/NCBI
4	Freeman R: Not all neuropathy in diabetes is of diabetic etiology: Differential diagnosis of diabetic neuropathy. Curr Diab Rep. 9:423–431. 2009. View Article : Google Scholar : PubMed/NCBI
5	Hirschfeld G, von Glischinski M, Blankenburg M and Zernikow B: Screening for peripheral neuropathies in children with diabetes: A systematic review. Pediatrics. 133:e1324–e1330. 2014. View Article : Google Scholar : PubMed/NCBI
6	Shehab DK, Al-Jarallah KF, Abraham M, Mojiminiyi OA, Al-Mohamedy H and Abdella NA: Back to basics: Ankle reflex in the evaluation of peripheral neuropathy in type 2 diabetes mellitus. QJM. 105:315–320. 2012. View Article : Google Scholar : PubMed/NCBI
7	Feng Y, Schlösser FJ and Sumpio BE: The Semmes Weinstein monofilament examination as a screening tool for diabetic peripheral neuropathy. J Vasc Surg. 50:675–682. 2009. View Article : Google Scholar : PubMed/NCBI
8	Zhang PH, Chen ZW, Lv D, Xu YY, Gu WL, Zhang XH, Le YL, Zhu HH and Zhu YM: Increased risk of cancer in patients with type 2 diabetes mellitus: A retrospective cohort study in China. BMC Public Health. 12:5672012. View Article : Google Scholar : PubMed/NCBI
9	Wohlschläger J, Wittekind C and Theegarten D: New TNM classification of malignant lung tumours. Pathologe. 31:355–360. 2010. View Article : Google Scholar : PubMed/NCBI
10	Azulay JP and Pouget J: Diabetic neuropathies. Rev Prat. 51:1783–1787. 2001.(Article in French). PubMed/NCBI
11	Wang D, Couture R and Hong Y: Activated microglia in the spinal cord underlies diabetic neuropathic pain. Eur J Pharmacol. 728:59–66. 2014. View Article : Google Scholar : PubMed/NCBI
12	Tesfaye S, Vileikyte L, Rayman G, Sindrup SH, Perkins BA, Baconja M, Vinik AI and Boulton AJ: Toronto Expert Panel on Diabetic Neuropathy: Painful diabetic peripheral neuropathy: Consensus recommendations on diagnosis, assessment and management. Diabetes Metab Res Rev. 27:629–638. 2011. View Article : Google Scholar : PubMed/NCBI
13	Kanaji N, Watanabe N, Kita N, Bandoh S, Tadokoro A, Ishii T, Dobashi H and Matsunaga T: Paraneoplastic syndromes associated with lung cancer. World J Clin Oncol. 5:197–223. 2014. View Article : Google Scholar : PubMed/NCBI
14	Honnorat J and Antoine JC: Paraneoplastic neurological syndromes. Orphanet J Rare Dis. 2:222007. View Article : Google Scholar : PubMed/NCBI
15	Graus F, Delattre JY, Antoine JC, Dalmau J, Giometto B, Grisold W, Honnorat J, Smitt PS, Vedeler Ch, Verschuuren JJ, et al: Recommended diagnostic criteria for paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry. 75:1135–1140. 2004. View Article : Google Scholar : PubMed/NCBI