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Article

Radiation‑induced pulmonary injury accelerated pulmonary metastasis in a mouse model of breast cancer

  • Authors:
    • Hong‑Yun Gong
    • Wei‑Guo Hu
    • Qin‑Yong Hu
    • Xiang‑Pan Li
    • Qi‑Bin Song
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Cancer Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
  • Pages: 3613-3618
    |
    Published online on: October 16, 2015
       https://doi.org/10.3892/ol.2015.3810
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Abstract

The aim of the present study was to investigate the acceleration of pulmonary metastasis due to pulmonary injury caused by radiation treatment in a mouse model of breast cancer, in addition to determining the associated mechanism. The passive metastatic breast cancer model was used in radiation‑treated BALB/c mice. In total, 24 mice were randomly separated into two groups, with 12 mice per group, and the groups were treated with or without pulmonary radiation. The survival time and variation of the weights of the lungs, spleen and liver were recorded. Lung metastasis was also evaluated, and chemokine (C‑X‑C motif) ligand 12 (CXCL12)/chemokine (C‑X‑C motif) receptor 4 (CXCR4) expression was determined. The results revealed that the group with radiation‑induced pulmonary injury exhibited an increased incidence of pulmonary metastasis and shorter survival time compared with the mice without pulmonary radiation. The radiation‑treated group possessed an increased number of metastatic nodules in the lungs, but metastasis was not evident in the liver and spleen. The CXCL12/CXCR4 axis was markedly expressed and the expression was significantly increased subsequent to radiation compared with the expression in normal lung tissues. The present study demonstrated that radiation‑induced pulmonary injury may accelerate metastatic tumor growth and decrease the overall survival rate of the mice following in situ injection of tumor cells. Tumor localization and growth may have been favored by metastatic conditioning in the lung subsequent to radiotherapy. The CXCL12/CXCR4 axis may affect key elements in the multistep process of metastasis induced by radiation injury.
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Copy and paste a formatted citation
Spandidos Publications style
Gong HY, Hu WG, Hu QY, Li XP and Song QB: Radiation‑induced pulmonary injury accelerated pulmonary metastasis in a mouse model of breast cancer. Oncol Lett 10: 3613-3618, 2015.
APA
Gong, H., Hu, W., Hu, Q., Li, X., & Song, Q. (2015). Radiation‑induced pulmonary injury accelerated pulmonary metastasis in a mouse model of breast cancer. Oncology Letters, 10, 3613-3618. https://doi.org/10.3892/ol.2015.3810
MLA
Gong, H., Hu, W., Hu, Q., Li, X., Song, Q."Radiation‑induced pulmonary injury accelerated pulmonary metastasis in a mouse model of breast cancer". Oncology Letters 10.6 (2015): 3613-3618.
Chicago
Gong, H., Hu, W., Hu, Q., Li, X., Song, Q."Radiation‑induced pulmonary injury accelerated pulmonary metastasis in a mouse model of breast cancer". Oncology Letters 10, no. 6 (2015): 3613-3618. https://doi.org/10.3892/ol.2015.3810
Copy and paste a formatted citation
x
Spandidos Publications style
Gong HY, Hu WG, Hu QY, Li XP and Song QB: Radiation‑induced pulmonary injury accelerated pulmonary metastasis in a mouse model of breast cancer. Oncol Lett 10: 3613-3618, 2015.
APA
Gong, H., Hu, W., Hu, Q., Li, X., & Song, Q. (2015). Radiation‑induced pulmonary injury accelerated pulmonary metastasis in a mouse model of breast cancer. Oncology Letters, 10, 3613-3618. https://doi.org/10.3892/ol.2015.3810
MLA
Gong, H., Hu, W., Hu, Q., Li, X., Song, Q."Radiation‑induced pulmonary injury accelerated pulmonary metastasis in a mouse model of breast cancer". Oncology Letters 10.6 (2015): 3613-3618.
Chicago
Gong, H., Hu, W., Hu, Q., Li, X., Song, Q."Radiation‑induced pulmonary injury accelerated pulmonary metastasis in a mouse model of breast cancer". Oncology Letters 10, no. 6 (2015): 3613-3618. https://doi.org/10.3892/ol.2015.3810
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