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Article

Lymph node density is a prognostic factor in patients with major salivary gland carcinoma

  • Authors:
    • Hidenori Suzuki
    • Nobuhiro Hanai
    • Hitoshi Hirakawa
    • Daisuke Nishikawa
    • Yasuhisa Hasegawa
  • View Affiliations / Copyright

    Affiliations: Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi 464‑8681, Japan
  • Pages: 3523-3528
    |
    Published online on: October 19, 2015
       https://doi.org/10.3892/ol.2015.3814
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Abstract

Lymph node density (LND) has been reported to be a significant predictor of survival in patients with oral and other carcinomas exhibiting positive lymph nodes. The present study investigated whether the LND is associated with overall survival in subjects with major salivary gland carcinoma. A total of 78 patients newly diagnosed with major salivary gland carcinoma underwent primary tumor resection and neck dissection without preoperative treatment. Of these 78 patients, 32 with pathologically positive lymph nodes were enrolled in the present study. The LND was calculated as the ratio of the number of positive lymph nodes to the number of total lymph nodes. The survival rate was analyzed according to the Kaplan‑Meier method. A univariate survival analysis was performed using the log‑rank test, and a multivariate survival analysis was performed using the Cox proportional hazards model. An LND of ≥0.38 was found to significantly correlate with a shorter overall survival time in univariate analysis (P=0.017). In multivariate survival analysis, after adjusting for anatomical location (parotid gland/others), an LND of ≥0.38 was identified to be associated with a significantly shorter overall survival time. These results suggest that the LND functions as a prognostic factor in cases of major salivary gland carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Suzuki H, Hanai N, Hirakawa H, Nishikawa D and Hasegawa Y: Lymph node density is a prognostic factor in patients with major salivary gland carcinoma. Oncol Lett 10: 3523-3528, 2015.
APA
Suzuki, H., Hanai, N., Hirakawa, H., Nishikawa, D., & Hasegawa, Y. (2015). Lymph node density is a prognostic factor in patients with major salivary gland carcinoma. Oncology Letters, 10, 3523-3528. https://doi.org/10.3892/ol.2015.3814
MLA
Suzuki, H., Hanai, N., Hirakawa, H., Nishikawa, D., Hasegawa, Y."Lymph node density is a prognostic factor in patients with major salivary gland carcinoma". Oncology Letters 10.6 (2015): 3523-3528.
Chicago
Suzuki, H., Hanai, N., Hirakawa, H., Nishikawa, D., Hasegawa, Y."Lymph node density is a prognostic factor in patients with major salivary gland carcinoma". Oncology Letters 10, no. 6 (2015): 3523-3528. https://doi.org/10.3892/ol.2015.3814
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki H, Hanai N, Hirakawa H, Nishikawa D and Hasegawa Y: Lymph node density is a prognostic factor in patients with major salivary gland carcinoma. Oncol Lett 10: 3523-3528, 2015.
APA
Suzuki, H., Hanai, N., Hirakawa, H., Nishikawa, D., & Hasegawa, Y. (2015). Lymph node density is a prognostic factor in patients with major salivary gland carcinoma. Oncology Letters, 10, 3523-3528. https://doi.org/10.3892/ol.2015.3814
MLA
Suzuki, H., Hanai, N., Hirakawa, H., Nishikawa, D., Hasegawa, Y."Lymph node density is a prognostic factor in patients with major salivary gland carcinoma". Oncology Letters 10.6 (2015): 3523-3528.
Chicago
Suzuki, H., Hanai, N., Hirakawa, H., Nishikawa, D., Hasegawa, Y."Lymph node density is a prognostic factor in patients with major salivary gland carcinoma". Oncology Letters 10, no. 6 (2015): 3523-3528. https://doi.org/10.3892/ol.2015.3814
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