Diffuse alveolar hemorrhage due to metastatic angiosarcoma of the lung: A case report

Pan,Zhijie; An,Zhou; Li,Yanyuan; Zhou,Jianying

doi:10.3892/ol.2015.3820

Diffuse alveolar hemorrhage due to metastatic angiosarcoma of the lung: A case report

Authors:
- Zhijie Pan
- Zhou An
- Yanyuan Li
- Jianying Zhou
View Affiliations

Affiliations: Department of Respiratory Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Department of Pathology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
Published online on: October 20, 2015 https://doi.org/10.3892/ol.2015.3820
Pages: 3853-3855

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Angiosarcoma is a rare, heterogeneous malignant tumor that derives from endothelial cells, and it has aggressive characteristics with a marked tendency for distant metastasis. Diffuse alveolar hemorrhage (DAH) is a catastrophic clinical syndrome, however, it is rare as the presentation of pulmonary angiosarcoma. To increase awareness with regard to angiosarcoma and DAH, the current study presents a case of angiosarcoma that originated from the subcutaneous soft tissue of the mastoid process, but was subject to a delayed diagnosis and rapid invasion into the brain and lung. The metastatic angiosarcoma of the lung presented with DAH as the initial manifestation. The pathological examination of a biopsy of the subcutaneous mass and pulmonary lesions confirmed the diagnosis of angiosarcoma. The patient succumbed to respiratory failure at 1 month post-diagnosis.

View Figures

View References

1	Saitoh J, Sakurai H, Suzuki Y, Katoh H, Takahashi T and Nakano T: Metastatic angiosarcoma of the lung with alveolar hemorrhage. Jpn J Radiol. 27:381–384. 2009. View Article : Google Scholar : PubMed/NCBI
2	Patel AM and Ryu JH: Angiosarcoma in the lung. Chest. 103:1531–1535. 1993. View Article : Google Scholar : PubMed/NCBI
3	Chen W, Shih CS, Wang YT, Tseng GC and Hsu WH: Angiosarcoma with pulmonary metastasis presenting with spontaneous bilateral pneumothorax in an elderly man. J Formos Med Assoc. 105:238–241. 2006. View Article : Google Scholar : PubMed/NCBI
4	Lara AR and Schwarz MI: Diffuse alveolar hemorrhage. Chest. 137:1164–1171. 2010. View Article : Google Scholar : PubMed/NCBI
5	Carillo GA, Carretero MA, Vazquez JE, Fontan EG, Ramos MB, Ventura JA, Rodriguez AP, Salmon AS and Tejedor JL: Epithelioid angiosarcoma of the lung with pleural metastasis: a rare cause of haemoptysis clinicopathological conference. Heart Lung Circ. 19:624–628. 2010. View Article : Google Scholar : PubMed/NCBI
6	Fayette J, Martin E, Piperno-Neumann S, Le Cesne A, Robert C, Bonvalot S, Ranchère D, Pouillart P, Coindre JM and Blay JY: Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: A retrospective study of 161 cases. Ann Oncol. 18:2030–2036. 2007. View Article : Google Scholar : PubMed/NCBI
7	Liu H, Huang X, Chen H, Wang X and Chen L: Epithelioid angiosarcoma of the kidney: A case report and literature review. Oncol Lett. 8:1155–1158. 2014.PubMed/NCBI
8	Ioachimescu OC and Stoller JK: Diffuse alveolar hemorrhage: Diagnosing it and finding the cause. Cleve Clin J Med. 75:258, 260, 264–265. 2008.
9	Adem C, Aubry MC, Tazelaar HD and Myers JL: Metastatic angiosarcoma masquerading as diffuse pulmonary hemorrhage: Clinicopathologic analysis of 7 new patients. Arch Pathol Lab Med. 125:1562–1565. 2001.PubMed/NCBI
10	Lanese DM and Pacht ER: Unusual presentation of metastatic scalp angiosarcoma: diagnosis by transbronchial lung biopsy. J Natl Med Assoc. 79:565–568. 1987.PubMed/NCBI
11	Choi KS, Chun HJ, Yi HJ and Kim JT: Intracranial invasion from recurrent angiosarcoma of the scalp. J Korean Neurosurg Soc. 43:201–204. 2008. View Article : Google Scholar : PubMed/NCBI
12	Ellegala DB, Kligori C, Vandenberg S, Dumont A and Shaffrey ME: Intracranial metastasis of a primary scalp angiosarcoma. Case illustration. J Neurosurg. 97:7252002. View Article : Google Scholar : PubMed/NCBI
13	Nair Somasekharan KK, Zabell AS, Vo KL and Shaikh MA: Pneumothorax: A classical presentation of metastatic scalp angiosarcoma. Ann Thorac Surg. 94:e77–e78. 2012. View Article : Google Scholar : PubMed/NCBI
14	Holden CA, Spittle MF and Jones EW: Angiosarcoma of the face and scalp, prognosis and treatment. Cancer. 59:1046–1057. 1987. View Article : Google Scholar : PubMed/NCBI