Olfactory neuroblastoma: A case report

Uslu,Gonca  Hanedan; Canyilmaz,Emine; Zengin,Ahmet  Yasar; Mungan,Sevdegul; Yoney,Adnan; Bahadir,Osman; Gocmez,Huseyin

doi:10.3892/ol.2015.3821

December-2015 Volume 10 Issue 6

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

December-2015 Volume 10 Issue 6

Full Size Image

Case Report

Olfactory neuroblastoma: A case report

Authors:
- Gonca Hanedan Uslu
- Emine Canyilmaz
- Ahmet Yasar Zengin
- Sevdegul Mungan
- Adnan Yoney
- Osman Bahadir
- Huseyin Gocmez
View Affiliations / Copyright

Affiliations: Department of Radiation Oncology, Faculty of Medicine, Kanuni Research and Education Hospital, Trabzon 61040, Turkey, Department of Radiation Oncology, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey, Department of Pathology, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey, Department of Otorhinolaryngology, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey
Pages: 3651-3654
|
Published online on: October 20, 2015

https://doi.org/10.3892/ol.2015.3821
Expand metrics +

Abstract

Olfactory neuroblastoma (ON) is a rare type of malignant neoplasm originating from the olfactory neuroepithelial cells of the nasal cavity. ON is also known as esthesioneuroblastoma or neuroendocrine carcinoma. The malignancy accounts for <3% of tumors originating in the nasal cavity. Through the nasal cavity, ON may infiltrate the sinuses, the orbit and the cranium. The tumor is characterized by a pattern of slow growth and local recurrences. Treatment options are surgical excision or surgery combined with a radiotherapy (RT) and/or chemotherapy combination treatment. The present study reports the case of a 69-year-old patient with a mass in the nasal cavity who was treated by combined surgical excision and RT. The literature for ON and the treatment of the tumor are also discussed.

View Figures

View References

1	Berger L, Luc R and Richard D: Olfactory esthesioneuroblastoma. Bull Assoc Fr Etude Cancer. 13:410–21. 1924.(In French).
2	Bhattacharyya N, Thornton AF, Joseph MP, Goodman ML and Amrein PC: Successful treatment of esthesioneuroblastoma and neuroendocrine carcinoma with combined chemotherapy and proton radiation. Results in 9 cases. Arch Otolaryngol Head Neck Surg. 123:34–40. 1997. View Article : Google Scholar : PubMed/NCBI
3	Rakes SM, Yeatts RP and Campbell RJ: Ophthalmic manifestations of esthesioneuroblastoma. Ophthalmology. 92:1749–53. 1985. View Article : Google Scholar : PubMed/NCBI
4	Kutluhan A, Yilmaz N, Yakut F, Yurttaş V and Uğraş S: Treatment of olfactory neuroblastoma via subfrontal and midfacial degloving approaches: A case report. Kulak Burun Bogaz Ihtis Derg. 18:56–8. 2008.(In Turkish). PubMed/NCBI
5	Fitzek MM, Thornton AF, Varvares M, Ancukiewicz M, Mcintyre J, Adams J, Rosenthal S, Joseph M and Amrein P: Neuroendocrine tumors of the sinonasal tract. Results of a prospective study incorporating chemotherapy, surgery, and combined proton-photon radiotherapy. Cancer. 94:2623–34. 2002. View Article : Google Scholar : PubMed/NCBI
6	Kleihues P and Cavenee WK: WHO Classification of Tumours of Pathology and Genetics Tumours of the Nervous System. Lyon, France: IARC Press. 150–152. 2000.
7	Weiss SW and Goldblum JR Enzinger: Primitive neuroectodermal tumors and related lesions. Enzinger and Weiss's Soft Tissue Tumors (4th). (Philadelphia, PA). Mosby Elsevier. 1308–1311. 2001.
8	Pickuth D, Heywang-Kobrunner SH and Spielmann RP: Computed tomography and magnetic resonance imaging features of olfactory neuroblastoma: an analysis of 22 cases. Clin Otolaryngol Allied Sci. 24:457–461. 1999. View Article : Google Scholar : PubMed/NCBI
9	Lund VJ, Howard D, Wei W and Spittle M: Olfactory neuroblastoma: Past, present, and future? Laryngoscope. 113:502–507. 2003. View Article : Google Scholar : PubMed/NCBI
10	Walch C, Stammberger H, Anderhuber W, Unger F, Kole W and Feichtinger K: The minimally invasive approach to olfactory neuroblastoma: combined endoscopic and stereotactic treatment. Laryngoscope. 110:635–640. 2000. View Article : Google Scholar : PubMed/NCBI
11	Kadish S, Goodman M and Wang CC: Olfactory neuroblastoma. A clinical analysis of 17 cases. Cancer. 37:1571–1576. 1976. View Article : Google Scholar : PubMed/NCBI
12	de Gabory L, Abdulkhaleq HM, Darrouzet V, Bébéar JP and Stoll D: Long-term results of 28 esthesioneuroblastomas managed over 35 years. Head Neck. 33:82–86. 2011. View Article : Google Scholar : PubMed/NCBI
13	Bhattacharyya N, Thornton AF, Joseph MP, Goodman ML and Amrein PC: Successful treatment of esthesioneuroblastoma and neuroendocrine carcinoma with combined chemotherapy and proton radiation. Results in 9 cases. Arch Otolaryngol Head Neck Surg. 123:34–40. 1997. View Article : Google Scholar : PubMed/NCBI
14	Howard DJ, Lund VJ and Wei WI: Craniofacial resection for tumors of the nasal cavity and paranasal sinuses: A 25-year experience. Head Neck. 28:867–873. 2006. View Article : Google Scholar : PubMed/NCBI
15	Morita A, Ebersold MJ, Olsen KD, Foote RL, Lewis JE and Quast LM: Esthesioneuroblastoma: prognosis and management. Neurosurgery. 32:706–714. 1993. View Article : Google Scholar : PubMed/NCBI
16	Aboziada MA and Eisbruch A: Esthesioneuroblastoma: the role of postoperative irradiation after complete surgical resection. J Egypt Natl Canc Inst. 22:143–148. 2010.PubMed/NCBI
17	Benfari G, Fusconi M, Ciofalo A, Gallo A, Altissimi G, Celani T and De Vincentiis M: Radiotherapy alone for local tumour control in esthesioneuroblastoma. Acta Otorhinolaryngol Ital. 28:292–297. 2008.PubMed/NCBI
18	Demiroz C, Gutfeld O, Aboziada M, Brown D, Marentette LJ and Eisbruch A: Esthesioneuroblastoma: is there a need for elective neck treatment? Int J Radiat Oncol Biol Phys. 15:255–261. 2011. View Article : Google Scholar
19	Montava M, Verillaud B, Kania R, Sauvaget E, Bresson D, Mancini J, Froelich S and Herman P: Critical analysis of recurrences of esthesioneuroblastomas: can we prevent them? Eur Arch Otorhinolaryngol. 271:3215–3222. 2014. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Olfactory neuroblastoma: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Related Articles