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Case Report Open Access

Malignant renal epithelioid angiomyolipoma: A case report and review of the literature

  • Authors:
    • Baoyin Guo
    • Hualin Song
    • Jiuling Yue
    • Gang Li
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Tianjin Baodi Hospital of Tianjin Medical University, Tianjin 300321, P.R. China, Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin 300211, P.R. China, Department of Head and Neck Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 95-98
    |
    Published online on: October 30, 2015
       https://doi.org/10.3892/ol.2015.3846
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Abstract

Malignant renal epithelioid angiomyolipoma (EAML) is rare, and currently there is no malignant criteria for its pathological diagnosis. In the present study, the case of a patient who suffered malignant renal EAML and underwent nephrectomy is reported. The histological patterns of the tumor were composed of sheets or nests of large polygonal epithelioid cells and thick‑walled blood vessels, with clear mitoses. Immunohistochemistry demonstrated that the epithelioid and smooth muscle cells characteristically expressed human melanoma black‑45, epithelial membrane antigen and actin. Pathological evaluation revealed malignant EAML with regional lymph node metastases. Magnetic resonance imaging and X‑ray examination identified multiple liver and lung nodules at 16 months post‑surgery. Since the patient did not respond to the initial treatment with doxorubicin and cisplatin, sorafenib was subsequently administered. However, the treatment was not effective, and the patient succumbed to multiple metastases six months later.
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Copy and paste a formatted citation
Spandidos Publications style
Guo B, Song H, Yue J and Li G: Malignant renal epithelioid angiomyolipoma: A case report and review of the literature. Oncol Lett 11: 95-98, 2016.
APA
Guo, B., Song, H., Yue, J., & Li, G. (2016). Malignant renal epithelioid angiomyolipoma: A case report and review of the literature. Oncology Letters, 11, 95-98. https://doi.org/10.3892/ol.2015.3846
MLA
Guo, B., Song, H., Yue, J., Li, G."Malignant renal epithelioid angiomyolipoma: A case report and review of the literature". Oncology Letters 11.1 (2016): 95-98.
Chicago
Guo, B., Song, H., Yue, J., Li, G."Malignant renal epithelioid angiomyolipoma: A case report and review of the literature". Oncology Letters 11, no. 1 (2016): 95-98. https://doi.org/10.3892/ol.2015.3846
Copy and paste a formatted citation
x
Spandidos Publications style
Guo B, Song H, Yue J and Li G: Malignant renal epithelioid angiomyolipoma: A case report and review of the literature. Oncol Lett 11: 95-98, 2016.
APA
Guo, B., Song, H., Yue, J., & Li, G. (2016). Malignant renal epithelioid angiomyolipoma: A case report and review of the literature. Oncology Letters, 11, 95-98. https://doi.org/10.3892/ol.2015.3846
MLA
Guo, B., Song, H., Yue, J., Li, G."Malignant renal epithelioid angiomyolipoma: A case report and review of the literature". Oncology Letters 11.1 (2016): 95-98.
Chicago
Guo, B., Song, H., Yue, J., Li, G."Malignant renal epithelioid angiomyolipoma: A case report and review of the literature". Oncology Letters 11, no. 1 (2016): 95-98. https://doi.org/10.3892/ol.2015.3846
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