Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2016 Volume 11 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2016 Volume 11 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Quantitative assessment of the association between glutathione S-transferase M1 polymorphism and the risk of developing nasopharyngeal cancer

  • Authors:
    • Yan Zhao
    • Yubao Wang
    • Xiaomei Wu
    • Jun Wang
    • Lijuan Zhang
    • Yuchi Jia
    • Wei Qi
  • View Affiliations / Copyright

    Affiliations: Tianjin Institute of Infectious Diseases, The Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China
  • Pages: 373-378
    |
    Published online on: October 30, 2015
       https://doi.org/10.3892/ol.2015.3848
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Glutathione S-transferases (GSTs) participate in the detoxification and elimination of electrophilic carcinogens by conjugating them to glutathione. Previous studies have reported a potential association between GSTM1 polymorphism and the risk of developing nasopharyngeal cancer (NPC). However, those findings remain controversial. In the present study, a meta‑analysis was conducted by pooling the odds ratios (ORs) with the corresponding 95% confidence intervals (CIs) of all the available case‑control studies on NPC. A comprehensive search of PubMed, Embase, Web of Science and China National Knowledge Infrastructure databases up to May 13th, 2014 was performed to identify eligible studies. A total of 12 separate publications, involving 1,593 cases of NPC and 2,868 controls, were included in the meta‑analysis. The results demonstrated that the null genotype of GSTM1 was significantly associated with increased risk of developing NPC (OR=1.530, 95% CI=1.348-1.737, Pheterogeneity=0.370). Subgroup analysis by ethnicity suggested that Asian carriers of the GSTM1 null genotype were more susceptible to NPC than individuals from other ethnic groups (OR=1.516, 95% CI=1.328-1.731, Pheterogeneity=0.270). Sensitivity analysis confirmed the stability of these observations. In conclusion, the results from the present meta‑analysis indicated that the GSTM1 polymorphism may be involved in the development of NPC, particularly in Asians.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Chang ET and Adami HO: The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 15:1765–1777. 2006. View Article : Google Scholar : PubMed/NCBI

3 

ONeil JD, Owen TJ, Wood VH, Date KL, Valentine R, Chukwuma MB, Arrand JR, Dawson CW and Young LS: Epstein-Barr virus-encoded EBNA1 modulates the AP-1 transcription factor pathway in nasopharyngeal carcinoma cells and enhances angiogenesis in vitro. J Gen Virol. 89:2833–2842. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Strange RC, Spiteri MA, Ramachandran S and Fryer AA: Glutathione-S-transferase family of enzymes. Mutat Res. 482:21–26. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Oakley A: Glutathione transferases: A structural perspective. Drug Metab Rev. 43:138–151. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Hayes JD and Strange RC: Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology. 61:154–166. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Zhang ZJ, Hao K, Shi R, Zhao G, Jiang GX, Song Y, Xu X and Ma J: Glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms, smoking, and their interaction in oral cancer: A HuGE review and meta-analysis. Am J Epidemiol. 173:847–857. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Taioli E, Flores-Obando RE, Agalliu I, Blanchet P, Bunker CH, Ferrell RE, Jackson M, Kidd LC, Kolb S, Lavender NA, et al: Multi-institutional prostate cancer study of genetic susceptibility in populations of African descent. Carcinogenesis. 32:1361–1365. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Nazar-Stewart V, Vaughan TL, Burt RD, Chen C, Berwick M and Swanson GM: Glutathione S-transferase M1 and susceptibility to nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 8:547–551. 1999.PubMed/NCBI

10 

Guo XL: Genetic polymorphism of cytochrome P450 1A1 and glutathione S-transferase Ml related with susceptibility of nasopharyngeal carcinoma. Hebei Med Univ. 2001.

11 

Da SJ, Liang B, Wu HL and Guan LL: Relationship between GSTM1 gene polymorphism and genetic susceptibility in nasopharyngeal carcinoma. Prac J of Cancer. 17:617–619. 2002.(In Chinese).

12 

Cheng YJ, Chien YC, Hildesheim A, Hsu MM, Chen IH, Chuang J, Chang J, Ma YD, Luo CT, Hsu WL, et al: No association between genetic polymorphisms of CYP1A1, GSTM1, GSTT1, GSTP1, NAT2, and nasopharyngeal carcinoma in Taiwan. Cancer Epidemiol Biomarkers Prev. 12:179–180. 2003.PubMed/NCBI

13 

Liu ZG, Wei YP and Ma Y: Population with GSTT1 gene deletion and the relationship to hepatocellular carcinoma from Guangxi. J Guangxi Med Univ. 20:161–163. 2003.(In Chinese).

14 

Deng ZL, Wei YP and Ma Y: Frequent genetic deletion of detoxifying enzyme GSTM1 and GSTT1 genes in nasopharyngeal carcinoma patients in Guangxi Province, China. Zhonghua Zhong Liu Za Zhi. 26:598–600. 2004.(In Chinese). PubMed/NCBI

15 

Deng ZL, Wei YP, Luo W, Liao ZL and Ma Y: Glutathione S-transferase M1 and T1 gene deletion associated with increased susceptibility to nasopharyngeal carcinoma. Chinese-German J Clin Oncol. 4:276–278. 2005. View Article : Google Scholar

16 

Tiwawech D, Srivatanakul P, Karalak A and Ishida T: Glutathione S-transferase M1 gene polymorphism in Thai nasopharyngeal carcinoma. Asian Pac J Cancer Prev. 6:270–275. 2005.PubMed/NCBI

17 

Bendjemana K, Abdennebi M, Gara S, Jmal A, Ghanem A, Touati S, Boussen H, Ladgham A and Guemira F: Genetic polymorphism of gluthation-S transferases and N-acetyl transferases 2 and nasopharyngeal carcinoma: The Tunisia experience. Bull Cancer. 93:297–302. 2006.PubMed/NCBI

18 

Guo X, OBrien SJ, Zeng Y, Nelson GW and Winkler CA: GSTM1 and GSTT1 gene deletions and the risk for nasopharyngeal carcinoma in Han Chinese. Cancer Epidemiol Biomarkers Prev. 17:1760–1763. 2008. View Article : Google Scholar : PubMed/NCBI

19 

He Y, Zhou GQ, Li X, Dong XJ, Chai XQ and Yao KT: Correlation of polymorphism of the coding region of glutathione S-transferase M1 to susceptibility of nasopharyngeal carcinoma in South China population. Ai Zheng. 28:5–7. 2009.(In Chinese). PubMed/NCBI

20 

Jiang Y, Li N, Dong P, Zhang N, Sun Y, Han M, Wen J and Chen M: Polymorphisms in GSTM1, GSTTI and GSTP1 and nasopharyngeal cancer in the East of China: a case-control study. Asian Pacif J Cancer Prev. 12:3097–3100. 2011.

21 

Wei YP, Long XD, Liu ZG, Ma Ya and Deng ZL: Genetic polymorphism of glutathione-S-transferase M1 and T1 in associated with carcinogenesis of hepatocellular carcinoma and nasopharyngeal carcinoma. Chinese-German J Clin Oncol. 11:138–141. 2012. View Article : Google Scholar

22 

Liao ZL, Deng ZL, Wei YP, Xie KS, Zhang B, Dai XM and Xu CS: Relationship of GSTT1 and GSTM1 gene polymorphisms with the development of nasopharyngeal carcinoma. J Guangxi Med Univ. 22:372–374. 2005.

23 

Tian SZ: The analysis of clinical factors related to laryngeal carcinoma and research on the association between genetic polymorphisms of xenobiotic-metabolizing enzymes. DNA repair genes and susceptibility to laryngeal carcinoma (Zhongshan Univ). 2001.

24 

DerSimonian R and Laird N: Meta-analysis in clinical trials. Control Clin Trials. 7:177–188. 1986. View Article : Google Scholar : PubMed/NCBI

25 

Mantel N and Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 22:719–748. 1959.PubMed/NCBI

26 

Cochran WG: The comparison of percentages in matched samples. Biometrika. 37:256–266. 1950. View Article : Google Scholar : PubMed/NCBI

27 

Higgins JP, Thompson SG, Deeks JJ and Altman DG: Measuring inconsistency in meta-analyses. BMJ. 327:557–560. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Stuck AE, Rubenstein LZ and Wieland D: Bias in meta-analysis detected by a simple, graphical test: Asymmetry detected in funnel plot was probably due to true heterogeneity. BMJ. 316:469–471. 1998. View Article : Google Scholar : PubMed/NCBI

29 

Egger M, Davey Smith G, Schneider M and Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ. 315:629–634. 1997. View Article : Google Scholar : PubMed/NCBI

30 

Tobias A, Saez M, Galan I and Campbell MJ: Sensitivity analysis of common statistical models used to study the short-term effects of air pollution on health. Int J Biometeorol. 47:227–229. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Hayes JD, Flanagan JU and Jowsey IR: Glutathione transferases. Annu Rev Pharmacol Toxicol. 45:51–88. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Sharma R, Yang Y, Sharma A, Awasthi S and Awasthi YC: Antioxidant role of glutathione S-transferases: Protection against oxidant toxicity and regulation of stress-mediated apoptosis. Antioxid Redox Signal. 6:289–300. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Strange RC, Lear JT and Fryer AA: Glutathione S-transferase polymorphisms: Influence on susceptibility to cancer. Chem Biol Interact. 111(112): 351–364. 1998. View Article : Google Scholar : PubMed/NCBI

34 

Moaven O, Raziee HR, Sima HR, Ganji A, Malekzadeh R, A'Rabi A, Abdollahi A, Memar B, Sotoudeh M, Naseh H, et al: Interactions between glutathione-S-transferase M1, T1 and P1 polymorphisms and smoking, and increased susceptibility to esophageal squamous cell carcinoma. Cancer Epidemiol. 34:285–290. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Karami S, Boffetta P, Rothman N, Hung RJ, Stewart T, Zaridze D, Navritalova M, Mates D, Janout V, Kollarova H, et al: Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms. Carcinogenesis. 29:1567–1571. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Sreeja L, Syamala V, Hariharan S, Syamala VS, Raveendran B, Sivanandan CD, Madhavan J and Ankathil R: Glutathione S-transferase M1, T1 and P1 polymorphisms: Susceptibility and outcome in lung cancer patients. J Exp Ther Oncol. 7:73–85. 2008.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Wang Y, Wu X, Wang J, Zhang L, Jia Y and Qi W: Quantitative assessment of the association between glutathione S-transferase M1 polymorphism and the risk of developing nasopharyngeal cancer. Oncol Lett 11: 373-378, 2016.
APA
Zhao, Y., Wang, Y., Wu, X., Wang, J., Zhang, L., Jia, Y., & Qi, W. (2016). Quantitative assessment of the association between glutathione S-transferase M1 polymorphism and the risk of developing nasopharyngeal cancer. Oncology Letters, 11, 373-378. https://doi.org/10.3892/ol.2015.3848
MLA
Zhao, Y., Wang, Y., Wu, X., Wang, J., Zhang, L., Jia, Y., Qi, W."Quantitative assessment of the association between glutathione S-transferase M1 polymorphism and the risk of developing nasopharyngeal cancer". Oncology Letters 11.1 (2016): 373-378.
Chicago
Zhao, Y., Wang, Y., Wu, X., Wang, J., Zhang, L., Jia, Y., Qi, W."Quantitative assessment of the association between glutathione S-transferase M1 polymorphism and the risk of developing nasopharyngeal cancer". Oncology Letters 11, no. 1 (2016): 373-378. https://doi.org/10.3892/ol.2015.3848
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Wang Y, Wu X, Wang J, Zhang L, Jia Y and Qi W: Quantitative assessment of the association between glutathione S-transferase M1 polymorphism and the risk of developing nasopharyngeal cancer. Oncol Lett 11: 373-378, 2016.
APA
Zhao, Y., Wang, Y., Wu, X., Wang, J., Zhang, L., Jia, Y., & Qi, W. (2016). Quantitative assessment of the association between glutathione S-transferase M1 polymorphism and the risk of developing nasopharyngeal cancer. Oncology Letters, 11, 373-378. https://doi.org/10.3892/ol.2015.3848
MLA
Zhao, Y., Wang, Y., Wu, X., Wang, J., Zhang, L., Jia, Y., Qi, W."Quantitative assessment of the association between glutathione S-transferase M1 polymorphism and the risk of developing nasopharyngeal cancer". Oncology Letters 11.1 (2016): 373-378.
Chicago
Zhao, Y., Wang, Y., Wu, X., Wang, J., Zhang, L., Jia, Y., Qi, W."Quantitative assessment of the association between glutathione S-transferase M1 polymorphism and the risk of developing nasopharyngeal cancer". Oncology Letters 11, no. 1 (2016): 373-378. https://doi.org/10.3892/ol.2015.3848
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team