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Epidermal growth factor receptor expression and gene copy number analysis in gastric carcinoma samples from Chinese patients

  • Authors:
    • Fan Zhang
    • Xingwu Yang
    • Lianhong Li
    • Lei Sun
    • Bo Wang
    • Xiaotang Yu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China, Department of Pathology and Forensic Medicine, Dalian Medical University, Dalian, Liaoning 116044, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 173-181
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    Published online on: November 5, 2015
       https://doi.org/10.3892/ol.2015.3875
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Abstract

Epidermal growth factor receptor (EGFR) expression and gene copy number have been observed to be associated with a positive clinical response to EGFR inhibitors. The present study aimed to evaluate EGFR expression and gene copy number in samples of gastric carcinoma (GC) from Chinese patients. EGFR expression and gene copy number were detected using immunohistochemistry and fluorescence in situ hybridization, in tissue array slides containing 150 individual samples of GC tissue. The association between EGFR status, clinicopathological features and overall patient survival was analyzed. Out of the 150 cases of GC evaluated, 63 (42.00%) demonstrated weak EGFR expression and 20 (13.33%) demonstrated EGFR overexpression. EGFR expression was observed to be associated with tumor location (P<0.05). Out of 104 cases of GC, which produced a clear FISH signal, 6 (5.77%) exhibited EGFR gene amplification and 5 (4.80%) exhibited balanced polysomy. Patients exhibiting GC, who demonstrated weak EGFR expression, EGFR overexpression or increased EGFR gene copy number, possessed an unfavorable prognosis. Multivariate analysis revealed that EGFR expression, tumor/node/metastasis stage and tumor location were potential independent unfavorable prognostic factors for GC patients. In conclusion, EGFR overexpression, gene amplification and polysomy were observed in GC patients and were associated with an unfavorable prognosis. Evaluation of EGFR status may therefore facilitate the identification of a subset of GC patients sensitive to treatment with EGFR-targeted therapies.
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1 

Amedei A, Benagiano M, della Bella C, Niccolai E and D'Elios MM: Novel immunotherapeutic strategies of gastric cancer treatment. J Biomed Biotechnol. 2011:4373482011. View Article : Google Scholar : PubMed/NCBI

2 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

3 

De Vita F, Di Martino N, Fabozzi A, Laterza MM, Ventriglia J, Savastano B, Petrillo A, Gambardella V, Sforza V, Maranwo L, et al: Clinical management of advanced gastric cancer: the role of new molecular drugs. World J Gastroenterol. 20:14537–14558. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Roviello F, Caruso S, Neri A and Marrelli D: Treatment and prevention of peritoneal carcinomatosis from gastric cancer by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: Overview and rationale. Eur J Surg Oncol. 39:1309–1316. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Yk W, Cf G, T Y, Z C, Xw Z, Xx L, Nl M and Wz Z: Assessment of ERBB2 and EGFR gene amplification and protein expression in gastric carcinoma by immunohistochemistry and fluorescence in situ hybridization. Mol Cytogenet. 4:142011. View Article : Google Scholar : PubMed/NCBI

6 

Ghosh MK, Sharma P, Harbor PC, Rahaman SO and Haque SJ: PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells. Oncogene. 24:7290–7300. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Yu XT, Zhu SN, Xu ZD, Hu XQ, Zhu TF, Chen JQ and Lu SL: Roles of EGFR-Stat3 signal pathway in carcinogenesis of experimental hepatoma in rats. J Cancer Res Clin Oncol. 133:145–152. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Mok TS, Lee K and Leung L: Targeting epidermal growth factor receptor in the management of lung cancer. Semin Oncol. 41:101–109. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Ruzzo A, Graziano F, Canestrari E and Magnani M: Molecular predictors of efficacy to anti-EGFR agents in colorectal cancer patients. Curr Cancer Drug Targets. 10:68–79. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Liang JL, Ren XC and Lin Q: Treating advanced non-small-cell lung cancer in Chinese patients: Focus on icotinib. Onco Targets Ther. 7:761–770. 2014.PubMed/NCBI

11 

Diasio RB and Fourie J: Targeting the epidermal growth factor receptor in the treatment of colorectal cancer: State of the art. Drugs. 66:1441–1463. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, et al: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 350:2129–2139. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Cappuzzo F, Hirsch FR, Rossi E, Bartolini S, Ceresoli GL, Bemis L, Haney J, Witta S, Danenberg K, Domenichini I, et al: Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst. 97:643–655. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Gamboa-Dominguez A, Dominguez-Fonseca C, Quintanilla-Martinez L, Reyes-Gutierrez E, Green D, Angeles-Angeles A, Busch R, Hermannstädter C, Nährig J, et al: Epidermal growth factor receptor expression correlates with poor survival in gastric adenocarcinoma from Mexican patients: A multivariate analysis using a standardized immunohistochemical detection system. Mod Pathol. 17:579–587. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Kim MA, Lee HS, Lee HE, Jeon YK, Yang HK and Kim WH: EGFR in gastric carcinomas: Prognostic significance of protein overexpression and high gene copy number. Histopathology. 52:738–746. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Lordick F, Kang YK, Chung HC, Salman P, Oh SC, Bodoky G, Kurteva G, Volovat C, Moiseyenko VM, Gorbunova V, et al: Arbeitsgemeinschaft Internistische Onkologie and EXPAND Investigators: Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): A randomised, open-label phase 3 trial. Lancet Oncol. 14:490–499. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Zhang L, Yang J, Cai J, Song X, Deng J, Huang X, Chen D, Yang M, Wery JP, Li S, et al: A subset of gastric cancers with EGFR amplification and overexpression respond to cetuximab therapy. Sci Rep. 3:29922013.PubMed/NCBI

18 

Kim JG: Molecular targeted therapy for advanced gastric cancer. Korean J Intern Med. 28:149–155. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Metzger B, Chambeau L, Begon DY, Faber C, Kayser J, Berchem G, Pauly M, Boniver J, Delvenne P, Dicato M and Wenner T: The human epidermal growth factor receptor (EGFR) gene in European patients with advanced colorectal cancer harbors infrequent mutations in its tyrosine kinase domain. BMC Med Genet. 12:1442011. View Article : Google Scholar : PubMed/NCBI

20 

Liang Z, Zeng X, Gao J, Wu S, Wang P, Shi X, Zhang J and Liu T: Analysis of EGFR, HER2, and TOP2A gene status and chromosomal polysomy in gastric adenocarcinoma from Chinese patients. BMC Cancer. 8:3632008. View Article : Google Scholar : PubMed/NCBI

21 

Wang Y, Jiang CQ, Guan J, Yang GF, Yue JQ, Chen HL, Xue JL, Xu ZG, Qian Q and Fan LF: Molecular alterations of EGFR in small intestinal adenocarcinoma. Int J Colorectal Dis. 28:1329–1335. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Ciardiello F and Tortora G: Epidermal growth factor receptor (EGFR) as a target in cancer therapy: Understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs. Eur J Cancer. 39:1348–1354. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Castañón E, Martín P, Rolfo C, Fusco JP, Ceniceros L, Legaspi J, Santisteban M and Gil-Bazo I: Epidermal Growth Factor Receptor targeting in non-small cell lung cancer: revisiting different strategies against the same target. Curr Drug Targets. 15:1273–1283. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Yarom N and Jonker DJ: The role of the epidermal growth factor receptor in the mechanism and treatment of colorectal cancer. Discov Med. 11:95–105. 2011.PubMed/NCBI

25 

Lozano MD, Zulueta JJ, Echeveste JI, Gúrpide A, Seijo LM, Martín-Algarra S, Del Barrio A, Pio R, Idoate MA, Labiano T and Perez-Gracia JL: Assessment of epidermal growth factor receptor and K-ras mutation status in cytological stained smears of non-small cell lung cancer patients: Correlation with clinical outcomes. Oncologist. 16:877–885. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Scartozzi M, Bearzi I, Mandolesi A, Pierantoni C, Loupakis F, Zaniboni A, Negri F, Quadri A, Zorzi F, Galizia E, et al: Epidermal Growth Factor Receptor (EGFR) gene copy number (GCN) correlates with clinical activity of irinotecan-cetuximab in K-RAS wild-type colorectal cancer: a fluorescence in situ (FISH) and chromogenic in situ hybridization (CISH) analysis. BMC Cancer. 9:303 View Article : Google Scholar : PubMed/NCBI

27 

Takehana T, Kunitomo K, Suzuki S, Kono K, Fujii H, Matsumoto Y and Ooi A: Expression of epidermal growth factor receptor in gastric carcinomas. Clin Gastroenterol Hepatol. 1:438–445. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Terashima M, Kitada K, Ochiai A, Ichikawa W, Kurahashi I, Sakuramoto S, Katai H, Sano T, Imamura H and Sasako M: ACTS-GC Group: Impact of expression of human epidermal growth factor receptors EGFR and ERBB2 on survival in stage II/III gastric cancer. Clin Cancer Res. 18:5992–6000. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Cappuzzo F, Finocchiaro G, Rossi E, Jänne PA, Carnaghi C, Calandri C, Bencardino K, Ligorio C, Ciardiello F, Pressiani T, et al: EGFR FISH assay predicts for response to cetuximab in chemotherapy refractory colorectal cancer patients. Ann Oncol. 19:717–723. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Economou M, Schöni L, Hammer C, Galván JA, Mueller DE and Zlobec I: Proper paraffin slide storage is crucial for translational research projects involving immunohistochemistry stains. Clin Transl Med. 3:42014. View Article : Google Scholar : PubMed/NCBI

31 

Brown LA and Huntsman D: Fluorescent in situ hybridization on tissue microarrays: challenges and solutions. J Mol Histol. 38:151–157. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Viana-Pereira M, Lopes JM, Little S, Milanezi F, Basto D, Pardal F, Jones C and Reis RM: Analysis of EGFR overexpression, EGFR gene amplification and the EGFRvIII mutation in Portuguese high-grade gliomas. Anticancer Res. 28:913–920. 2008.PubMed/NCBI

33 

Rojo F, Tabernero J, Albanell J, Van Cutsem E, Ohtsu A, Doi T, Koizumi W, Shirao K, Takiuchi H, Cajal Ramon YS and Baselga J: Pharmacodynamic studies of gefitinib in tumor biopsy specimens from patients with advanced gastric carcinoma. J Clin Oncol. 24:4309–4316. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Dragovich T, McCoy S, Fenoglio-Preiser CM, Wang J, Benedetti JK, Baker AF, Hackett CB, Urba SG, Zaner KS, Blanke CD and Abbruzzese JL: Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127. J Clin Oncol. 24:4922–4927. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Gancberg D, Di Leo A, Rouas G, Järvinen T, Verhest A, Isola J, Piccart MJ and Larsimont D: Reliability of the tissue microarray based FISH for evaluation of the HER-2 oncogene in breast carcinoma. J Clin Pathol. 55:315–317. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Lièvre A, Bachet JB, Le Corre D, Boige V, Landi B, Emile JF, Côté JF, Tomasic G, Penna C, Ducreux M, et al: KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 66:3992–3995. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Fukuda K, Saikawa Y, Takahashi M, Takahashi T, Wada N, Kawakubo H, Takeuchi H and Kitagawa Y: Antitumor effect of cetuximab in combination with S-1 in EGFR-amplified gastric cancer cells. Int J Oncol. 40:975–982. 2012.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang F, Yang X, Li L, Sun L, Wang B and Yu X: Epidermal growth factor receptor expression and gene copy number analysis in gastric carcinoma samples from Chinese patients. Oncol Lett 11: 173-181, 2016.
APA
Zhang, F., Yang, X., Li, L., Sun, L., Wang, B., & Yu, X. (2016). Epidermal growth factor receptor expression and gene copy number analysis in gastric carcinoma samples from Chinese patients. Oncology Letters, 11, 173-181. https://doi.org/10.3892/ol.2015.3875
MLA
Zhang, F., Yang, X., Li, L., Sun, L., Wang, B., Yu, X."Epidermal growth factor receptor expression and gene copy number analysis in gastric carcinoma samples from Chinese patients". Oncology Letters 11.1 (2016): 173-181.
Chicago
Zhang, F., Yang, X., Li, L., Sun, L., Wang, B., Yu, X."Epidermal growth factor receptor expression and gene copy number analysis in gastric carcinoma samples from Chinese patients". Oncology Letters 11, no. 1 (2016): 173-181. https://doi.org/10.3892/ol.2015.3875
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang F, Yang X, Li L, Sun L, Wang B and Yu X: Epidermal growth factor receptor expression and gene copy number analysis in gastric carcinoma samples from Chinese patients. Oncol Lett 11: 173-181, 2016.
APA
Zhang, F., Yang, X., Li, L., Sun, L., Wang, B., & Yu, X. (2016). Epidermal growth factor receptor expression and gene copy number analysis in gastric carcinoma samples from Chinese patients. Oncology Letters, 11, 173-181. https://doi.org/10.3892/ol.2015.3875
MLA
Zhang, F., Yang, X., Li, L., Sun, L., Wang, B., Yu, X."Epidermal growth factor receptor expression and gene copy number analysis in gastric carcinoma samples from Chinese patients". Oncology Letters 11.1 (2016): 173-181.
Chicago
Zhang, F., Yang, X., Li, L., Sun, L., Wang, B., Yu, X."Epidermal growth factor receptor expression and gene copy number analysis in gastric carcinoma samples from Chinese patients". Oncology Letters 11, no. 1 (2016): 173-181. https://doi.org/10.3892/ol.2015.3875
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