Analysis of factors affecting endocrine therapy resistance in breast cancer

  • Authors:
    • Min Zhang
    • Hui Chen
    • Jun Gu
  • View Affiliations

  • Published online on: November 6, 2015     https://doi.org/10.3892/ol.2015.3887
  • Pages: 379-384
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Abstract

The present study aimed to identify the factors involved in the resistance to endocrine therapy in breast cancer (BC) patients with a positive estrogen receptor status via the collection of clinical, pathological and immunohistochemical indices. A retrospective survey was performed in patients who experienced the relapse and metastasis of BC between November 2007 and March 2013. A total of 45 patients were enrolled, and the observational duration was 7‑84 months. The Kaplan‑Meier method was used to create a survival curve, while the log‑rank test was used to analyze the survival curve and the Cox regression analysis was used to investigate the associated factors contributing to the resistance to endocrine therapy. Univariate analysis showed that the age of onset, the use of radiotherapy, the endocrine treatment program, and the expression levels of progesterone receptor (PR) and CerbB2 affected the impact of endocrine treatment. The Cox regression analysis indicated that the age of onset, the use of radiotherapy, and the expression levels of PR and CerbB2 affected the disease‑free survival time after endocrine therapy. A young age of onset, not receiving radiotherapy, a low expression level of PR and a high expression level of CerbB2 were the risk factors involved in the resistance to endocrine therapy in patients with BC.
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January-2016
Volume 11 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang M, Chen H and Gu J: Analysis of factors affecting endocrine therapy resistance in breast cancer. Oncol Lett 11: 379-384, 2016
APA
Zhang, M., Chen, H., & Gu, J. (2016). Analysis of factors affecting endocrine therapy resistance in breast cancer. Oncology Letters, 11, 379-384. https://doi.org/10.3892/ol.2015.3887
MLA
Zhang, M., Chen, H., Gu, J."Analysis of factors affecting endocrine therapy resistance in breast cancer". Oncology Letters 11.1 (2016): 379-384.
Chicago
Zhang, M., Chen, H., Gu, J."Analysis of factors affecting endocrine therapy resistance in breast cancer". Oncology Letters 11, no. 1 (2016): 379-384. https://doi.org/10.3892/ol.2015.3887