Magnifying chromoendoscopic and endocytoscopic findings of juvenile polyps in the colon and rectum

Takeda,Kenichi; Kudo,Shin‑Ei; Mori,Yuichi; Misawa,Masashi; Kudo,Toyoki; Wakamura,Kunihiko; Hayashi,Takemasa; Miyachi,Hideyuki; Ishida,Fumio; Inoue,Haruhiro

doi:10.3892/ol.2015.3910

January-2016 Volume 11 Issue 1

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January-2016 Volume 11 Issue 1

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Article

Magnifying chromoendoscopic and endocytoscopic findings of juvenile polyps in the colon and rectum

Authors:
- Kenichi Takeda
- Shin‑Ei Kudo
- Yuichi Mori
- Masashi Misawa
- Toyoki Kudo
- Kunihiko Wakamura
- Takemasa Hayashi
- Hideyuki Miyachi
- Fumio Ishida
- Haruhiro Inoue
View Affiliations / Copyright

Affiliations: Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Kanagawa 224‑8503, Japan, Digestive Disease Center, Showa University Koto‑Toyosu Hospital, Tokyo 135‑8577, Japan
Pages: 237-242
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Published online on: November 10, 2015

https://doi.org/10.3892/ol.2015.3910
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Abstract

A precise endoscopic diagnosis is necessary for endoscopic therapy for neoplastic and non‑neoplastic lesions, including juvenile polyps (JPs). Therefore, the present study aimed to clarify the characteristic endoscopic findings of JPs. A total of 154 JPs were evaluated by magnifying chromoendoscopy, 20 of which were also assessed by endocytoscopy using an ultra‑high magnification endoscope. Endoscopic images were evaluated in terms of gross appearance, color, pit pattern, surface inflammatory changes and vascularity of polyps. Endocytoscopic images were evaluated with regard to the morphology of glandular cavities, nuclei of glandular cells and interstitial features. Reddish surfaces (98.1%), surface erosion (92.2%), open pits (90.3%) and low pit density (90.3%) were observed in the majority of JPs by chromoendoscopy. In addition, dilated ductal openings surrounded by normal glandular cells (100%), greater distances between gland basal layers (100%) and interstitial infiltration by inflammatory cells (100%) were observed in all JPs examined by endocytoscopy. These findings indicate that there is a tetralogy of magnifying chromoendoscopic findings characteristic of JPs: Reddish surfaces, surface erosion, open pits and low pit density. There is also a triad of endocytoscopic findings characteristic of JPs, namely dilated ductal openings surrounded by normal glandular cells, greater distances between gland basal layers, and interstitial infiltration by inflammatory cells. The aforementioned magnifying chromoendoscopic and endocytoscopic characteristics of JPs may be useful factors for diagnosing JPs.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Magnifying chromoendoscopic and endocytoscopic findings of juvenile polyps in the colon and rectum

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