Open Access

Effects of plant‑derived anti‑leukemic drugs on individualized leukemic cell population profiles in Egyptian patients

  • Authors:
    • Mourad A. M. Aboul‑Soud
    • Hany A. El‑Shemy
    • Khalid M. Aboul‑Enein
    • Ali M. Mahmoud
    • Ahmed M. Al‑Abd
    • David A. Lightfoot
  • View Affiliations

  • Published online on: November 13, 2015     https://doi.org/10.3892/ol.2015.3916
  • Pages: 642-648
  • Copyright: © Aboul‑Soud et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Leukemias are a group of cancer types that originate from blood‑forming tissues. In this disease, an abnormally large number of immature white blood cells is produced by the bone marrow. The relationship between treatments with plant‑derived drugs and leukemia‑associated immuno­phenotypes (LAIPs) of clinically isolated leukemia cells has yet to be established. The aim of the present study was to develop a preliminary clinical prognostic map for commonly expressed LAIPs in patients clinically diagnosed with leukemia, as well as to assess the potential involvement of LAIPs in the response rate to 10 natural products of plant origin. An increased expression of LAIPs, including CD4, CD14, CD33 and CD34, was considered a surrogate marker of the desired response of leukemia cells to treatment with plant‑derived drugs. By contrast, the increased expression of the LAIPs, MPO and DR, was associated with poor prognostic outcomes following treatment with the plant‑derived drugs. The results showed that 5 of the 10 plant‑derived drugs tested induced the expression of several desirable LAIPs biomarkers. These findings clearly highlight the potential treatment efficacy of certain plant‑derived drugs against leukemic cell types.
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January-2016
Volume 11 Issue 1

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Spandidos Publications style
Aboul‑Soud MA, El‑Shemy HA, Aboul‑Enein KM, Mahmoud AM, Al‑Abd AM and Lightfoot DA: Effects of plant‑derived anti‑leukemic drugs on individualized leukemic cell population profiles in Egyptian patients. Oncol Lett 11: 642-648, 2016
APA
Aboul‑Soud, M.A., El‑Shemy, H.A., Aboul‑Enein, K.M., Mahmoud, A.M., Al‑Abd, A.M., & Lightfoot, D.A. (2016). Effects of plant‑derived anti‑leukemic drugs on individualized leukemic cell population profiles in Egyptian patients. Oncology Letters, 11, 642-648. https://doi.org/10.3892/ol.2015.3916
MLA
Aboul‑Soud, M. A., El‑Shemy, H. A., Aboul‑Enein, K. M., Mahmoud, A. M., Al‑Abd, A. M., Lightfoot, D. A."Effects of plant‑derived anti‑leukemic drugs on individualized leukemic cell population profiles in Egyptian patients". Oncology Letters 11.1 (2016): 642-648.
Chicago
Aboul‑Soud, M. A., El‑Shemy, H. A., Aboul‑Enein, K. M., Mahmoud, A. M., Al‑Abd, A. M., Lightfoot, D. A."Effects of plant‑derived anti‑leukemic drugs on individualized leukemic cell population profiles in Egyptian patients". Oncology Letters 11, no. 1 (2016): 642-648. https://doi.org/10.3892/ol.2015.3916