Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2016 Volume 11 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2016 Volume 11 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effects of plant‑derived anti‑leukemic drugs on individualized leukemic cell population profiles in Egyptian patients

  • Authors:
    • Mourad A. M. Aboul‑Soud
    • Hany A. El‑Shemy
    • Khalid M. Aboul‑Enein
    • Ali M. Mahmoud
    • Ahmed M. Al‑Abd
    • David A. Lightfoot
  • View Affiliations / Copyright

    Affiliations: Faculty of Agriculture Research Park (FARP) and Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza 12613, Egypt, Department of Clinical Pathology, National Cancer Institute, Cairo University, Cairo 12513, Egypt, Department of Pharmacology, Medical Division, National Research Centre, Cairo 11796, Egypt, Genomics Core‑Facility, Southern Illinois University, Carbondale, IL 62901, USA
    Copyright: © Aboul‑Soud et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 642-648
    |
    Published online on: November 13, 2015
       https://doi.org/10.3892/ol.2015.3916
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Leukemias are a group of cancer types that originate from blood‑forming tissues. In this disease, an abnormally large number of immature white blood cells is produced by the bone marrow. The relationship between treatments with plant‑derived drugs and leukemia‑associated immuno­phenotypes (LAIPs) of clinically isolated leukemia cells has yet to be established. The aim of the present study was to develop a preliminary clinical prognostic map for commonly expressed LAIPs in patients clinically diagnosed with leukemia, as well as to assess the potential involvement of LAIPs in the response rate to 10 natural products of plant origin. An increased expression of LAIPs, including CD4, CD14, CD33 and CD34, was considered a surrogate marker of the desired response of leukemia cells to treatment with plant‑derived drugs. By contrast, the increased expression of the LAIPs, MPO and DR, was associated with poor prognostic outcomes following treatment with the plant‑derived drugs. The results showed that 5 of the 10 plant‑derived drugs tested induced the expression of several desirable LAIPs biomarkers. These findings clearly highlight the potential treatment efficacy of certain plant‑derived drugs against leukemic cell types.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR and Sultan C: Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br J Haematol. 33:451–458. 1976. View Article : Google Scholar : PubMed/NCBI

2 

Bain BJ: Acute leukemia cytology, cytochemistry and the FAB classification. Leukemia Diagnosis. Bain J: Chapter 2. (2nd). (Oxford, UK). Blackwell Science. 1–52. 1999.

3 

Bray F, Jemal A, Grey N, Ferlay J and Forman D: Global cancer transitions according to the Human Development Index (2008–2030): a population-based study. Lancet Oncol. 13:790–801. 2012. View Article : Google Scholar : PubMed/NCBI

4 

American Cancer Society: Global Cancer Facts & Figures (3rd). Atlanta, GA: American Cancer Society. 2015.

5 

American Cancer Society: Cancer Facts & Figures 2014. Atlanta, GA: American Cancer Society. 2014.

6 

Tadmouri GO, Nair P, Obeid T and Gallala S: Genetics Made Easy 2: Cancers. Center for Arab Genomic Studies. http://www.cags.org.ae/gme2cancersenleukemia.pdfAccessed. Feb 22–2015

7 

El-Shemy HA, Aboul-Enein AM, Aboul-Enein MI, Issa SI and Fujita K: The effect of willow leaf extracts on human leukemic cells in vitro. J Biochem Mol Biol. 36:387–389. 2003. View Article : Google Scholar : PubMed/NCBI

8 

El-Shemy HA, Aboul-Enein AM, Aboul-Enein KM and Fujita K: Willow leaves' extracts contain anti-tumor agents effective against three cell types. PLoS One. 2:e1782007. View Article : Google Scholar : PubMed/NCBI

9 

Elgendi HM, Mekawy MA, Abdel Wahab SE, Tawfik LM, Ismail EA and Adly AA: AC133 expression in egyptian children with acute leukemia: impact on treatment response and disease outcome. J Pediatr Hematol Oncol. 32:286–293. 2010. View Article : Google Scholar : PubMed/NCBI

10 

No authors listed: All natural. Nat Chem Biol. 3:3512007. View Article : Google Scholar : PubMed/NCBI

11 

Krause J and Tobin G: Discovery, Development, and Regulation of Natural Products. Using Old Solutions to New Problems - Natural Drug Discovery in the 21st Century. Marianna Kulka: InTech. 424(Rijeka, Croatia). 2013.

12 

Schwartsmann G: Marine organisms and other novel natural sources of new cancer drugs. Ann Oncol. 11(Suppl 3): 235–243. 2000. View Article : Google Scholar : PubMed/NCBI

13 

McChesney JD, Venkataraman SK and Henri JT: Plant natural products: back to the future or into extinction? Phytochemistry. 68:2015–2022. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Rout SP, Choudary KA, Kar DM, Das L and Jain A: Plants in traditional medicinal system - Future source of new drugs. Int J Pharm Pharm Sci. 1:1–23. 2009.

15 

Beutler JA: Natural Products as a Foundation for Drug Discovery. Curr Protoc Pharmacol. 46:9.11.1–9.11.21. 2009.

16 

Cragg GM and Newman DJ: Plants as a source of anti-cancer agents. J Ethnopharmacol. 100:72–79. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Raskin I, Ribnicky DM, Komarnytsky S, Ilic N, Poulev A, Borisjuk N, Brinker A, Moreno DA, Ripoll C, Yakoby N, et al: Plants and human health in the twenty-first century. Trends Biotechnol. 20:522–531. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Kishimoto T, Kikutani H, Von dem Borne AEG Jr, Goyert SM, Mason DY, Miyasaka M, Moretta L, Okumura K, Shaw S, Springer TA, Sugamura K and Zola H: Leukocyte Typing VI. White Cell Differentiation Antigens (New York, NY). Garland Publishing, Inc. 1997.

19 

Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA and Bloomfield CD: World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol. 17:3835–3849. 1999.PubMed/NCBI

20 

Borowitz MJ and Chan JK: Precursor lymphoid neoplasms. WHO classification of tumours of haematopoietic and lymphoid tissues. Swerdlow SH, Campo E, Harris NL, et al: (4th). (Lyon). International Agency for Research on Cancer. 167–178. 2008.

21 

Xu F, Yin CX, Wang CL, et al: Immunophenotypes and Immune Markers Associated with Acute Promyelocytic Leukemia Prognosis. Dis Markers. 2014:4219062014. View Article : Google Scholar : PubMed/NCBI

22 

Robbins SL, Kumar V and Cotran RS: Robbins and Cotran Pathologic Basis of Disease. Philadelphia, PA: Elsevier. 2010.

23 

Fielding AK: Current treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia. Hematology (Am Soc Hematol Educ Program). 2011:231–237. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Chen B, Wang YY, Shen Y, Zhang WN, He HY, Zhu YM, Chen HM, Gu CH, Fan X, Chen JM, et al: Newly diagnosed acute lymphoblastic leukemia in China (I): abnormal genetic patterns in 1346 childhood and adult cases and their comparison with the reports from Western countries. Leukemia. 26:1608–1616. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Mi JQ, Wang X, Yao Y, Lu HJ, Jiang XX, Zhou JF, Wang JH, Jiao B, Shen SH, Tang JY, et al: Newly diagnosed acute lymphoblastic leukemia in China (II): prognosis related to genetic abnormalities in a series of 1091 cases. Leukemia. 26:1507–1516. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Brüggemann M, Droese J, Bolz I, Lüth P, Pott C, von Neuhoff N, Scheuering U and Kneba M: Improved assessment of minimal residual disease in B cell malignancies using fluorogenic consensus probes for real-time quantitative PCR. Leukemia. 14:1419–1425. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Kerst G, Kreyenberg H, Roth C, Well C, Dietz K, Coustan-Smith E, Campana D, Koscielniak E, Niemeyer C, Schlegel PG, et al: Concurrent detection of minimal residual disease (MRD) in childhood acute lymphoblastic leukaemia by flow cytometry and real-time PCR. Br J Haematol. 128:774–782. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Salem DA and Abd El-Aziz SM: Flowcytometric immunophenotypic profile of acute leukemia: mansoura experience. Indian J Hematol Blood Transfus. 28:89–96. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Denys B, van der Sluijs-Gelling AJ, Homburg C, van der Schoot CE, de Haas V, Philippé J, Pieters R, van Dongen JJ and van der Velden VH: Improved flow cytometric detection of minimal residual disease in childhood acute lymphoblastic leukemia. Leukemia. 27:635–641. 2013. View Article : Google Scholar : PubMed/NCBI

30 

El-Shemy HA, Aboul-Soud MA, Nassr-Allah AA, Aboul-Enein KM, Kabash A and Yagi A: Antitumor properties and modulation of antioxidant enzymes' activity by Aloe vera leaf active principles isolated via supercritical carbon dioxide extraction. Curr Med Chem. 17:129–138. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Han SS, Keum YS, Seo HJ and Surh YJ: Curcumin suppresses activation of NF-kappaB and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells. J Biochem Mol Biol. 35:337–342. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Shanab SM, Shalaby EA, Lightfoot DA and El-Shemy HA: Allelopathic effects of water hyacinth (Eichhornia crassipes). PLoS One. 5:e132002010. View Article : Google Scholar : PubMed/NCBI

33 

Ieven M, Van den Berghe DA, Mertens F, Vlietinck A and Lammens E: Screening of higher plants for biological activities. I. Antimicrobial activity. Planta Med. 36:311–321. 1979. View Article : Google Scholar : PubMed/NCBI

34 

Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, et al: Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 275:218–220. 1997. View Article : Google Scholar : PubMed/NCBI

35 

Lawson K: Botanical and Plant-derived Drugs: Global Markets. BCC Research. 2013.

36 

Shaked Y, Emmenegger U, Francia G, Chen L, Lee CR, Man S, Paraghamian A, Ben-David Y and Kerbel RS: Low-dose metronomic combined with intermittent bolus-dose cyclophosphamide is an effective long-term chemotherapy treatment strategy. Cancer Res. 65:7045–7051. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Onodera T, Poe JC, Tedder TF and Tsubata T: CD22 regulates time course of both B cell division and antibody response. J Immunol. 180:907–913. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Forsyth RG, De Boeck G, Baelde JJ, Taminiau AH, Uyttendaele D, Roels H, Praet MM and Hogendoorn PC: CD33+ CD14- phenotype is characteristic of multinuclear osteoclast-like cells in giant cell tumor of bone. J Bone Miner Res. 24:70–77. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Gorin NC, Labopin M, Reiffers J, Milpied N, Blaise D, Witz F, de Witte T, Meloni G, Attal M, Bernal T, et al: Acute Leukemia Working Party, European Cooperative Group for Blood and Marrow Transplantation: Higher incidence of relapse in patients with acute myelocytic leukemia infused with higher doses of CD34+ cells from leukapheresis products autografted during the first remission. Blood. 116:3157–3162. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Kamel AM, Assem MM, Jaffe ES, Magrath I, Enein Aboul MI and Hindawy DS: Immunological phenotypic pattern of acute lymphoblastic leukaemia in Egypt. Leuk Res. 13:519–525. 1989. View Article : Google Scholar : PubMed/NCBI

41 

McDermott U and Settleman J: Personalized cancer therapy with selective kinase inhibitors: an emerging paradigm in medical oncology. J Clin Oncol. 27:5650–5659. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Tantawy AA, El-Bostany EA, Adly AA, El Abou Asrar M, El-Ghouroury EA and Abdulghaffar EE: Methylene tetrahydrofolate reductase gene polymorphism in Egyptian children with acute lymphoblastic leukemia. Blood Coagul Fibrinolysis. 21:28–34. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Herzog CM, Dey S, Hablas A, et al: Geographic distribution of hematopoietic cancers in the Nile delta of Egypt. Ann Oncol. 23:2748–2755. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Aboul‑Soud MA, El‑Shemy HA, Aboul‑Enein KM, Mahmoud AM, Al‑Abd AM and Lightfoot DA: Effects of plant‑derived anti‑leukemic drugs on individualized leukemic cell population profiles in Egyptian patients. Oncol Lett 11: 642-648, 2016.
APA
Aboul‑Soud, M.A., El‑Shemy, H.A., Aboul‑Enein, K.M., Mahmoud, A.M., Al‑Abd, A.M., & Lightfoot, D.A. (2016). Effects of plant‑derived anti‑leukemic drugs on individualized leukemic cell population profiles in Egyptian patients. Oncology Letters, 11, 642-648. https://doi.org/10.3892/ol.2015.3916
MLA
Aboul‑Soud, M. A., El‑Shemy, H. A., Aboul‑Enein, K. M., Mahmoud, A. M., Al‑Abd, A. M., Lightfoot, D. A."Effects of plant‑derived anti‑leukemic drugs on individualized leukemic cell population profiles in Egyptian patients". Oncology Letters 11.1 (2016): 642-648.
Chicago
Aboul‑Soud, M. A., El‑Shemy, H. A., Aboul‑Enein, K. M., Mahmoud, A. M., Al‑Abd, A. M., Lightfoot, D. A."Effects of plant‑derived anti‑leukemic drugs on individualized leukemic cell population profiles in Egyptian patients". Oncology Letters 11, no. 1 (2016): 642-648. https://doi.org/10.3892/ol.2015.3916
Copy and paste a formatted citation
x
Spandidos Publications style
Aboul‑Soud MA, El‑Shemy HA, Aboul‑Enein KM, Mahmoud AM, Al‑Abd AM and Lightfoot DA: Effects of plant‑derived anti‑leukemic drugs on individualized leukemic cell population profiles in Egyptian patients. Oncol Lett 11: 642-648, 2016.
APA
Aboul‑Soud, M.A., El‑Shemy, H.A., Aboul‑Enein, K.M., Mahmoud, A.M., Al‑Abd, A.M., & Lightfoot, D.A. (2016). Effects of plant‑derived anti‑leukemic drugs on individualized leukemic cell population profiles in Egyptian patients. Oncology Letters, 11, 642-648. https://doi.org/10.3892/ol.2015.3916
MLA
Aboul‑Soud, M. A., El‑Shemy, H. A., Aboul‑Enein, K. M., Mahmoud, A. M., Al‑Abd, A. M., Lightfoot, D. A."Effects of plant‑derived anti‑leukemic drugs on individualized leukemic cell population profiles in Egyptian patients". Oncology Letters 11.1 (2016): 642-648.
Chicago
Aboul‑Soud, M. A., El‑Shemy, H. A., Aboul‑Enein, K. M., Mahmoud, A. M., Al‑Abd, A. M., Lightfoot, D. A."Effects of plant‑derived anti‑leukemic drugs on individualized leukemic cell population profiles in Egyptian patients". Oncology Letters 11, no. 1 (2016): 642-648. https://doi.org/10.3892/ol.2015.3916
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team