Prostatic adenocarcinoma presenting with metastases to the testis and epididymis: A case report

Zhang,Jin; Dong,Mei; Hu,Xiaolei; Liu,Lin; Li,Shen; Li,Chao; Yang,Lijun; Xiao,Yongqiang; Pang,Shujian; Wang,Chuan

doi:10.3892/ol.2015.3920

January-2016 Volume 11 Issue 1

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January-2016 Volume 11 Issue 1

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Case Report

Prostatic adenocarcinoma presenting with metastases to the testis and epididymis: A case report

Authors:
- Jin Zhang
- Mei Dong
- Xiaolei Hu
- Lin Liu
- Shen Li
- Chao Li
- Lijun Yang
- Yongqiang Xiao
- Shujian Pang
- Chuan Wang
View Affiliations / Copyright

Affiliations: Department of Urology, The First Hospital of Shijiazhuang, Shijiazhuang, Hebei, P.R. China, Department of Surgery, The Affiliated Hospital of Hebei Science and Technology University, Shijiazhuang, Hebei, P.R. China, Department of Pharmacology, Hebei Medical University, Shijiazhuang, Hebei, P.R. China
Pages: 792-794
|
Published online on: November 16, 2015

https://doi.org/10.3892/ol.2015.3920
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Abstract

Few cases of testicular metastases from prostate carcinoma have been reported, and asymptomatic metastases of prostate carcinoma to both the testis and epididymis are extremely rare. The current study presents the case of a 69-year-old male with testicular and epididymal metastases from prostate carcinoma. The patient was admitted to The First Hospital of Shijiazhuang with a 2-year history of lower urinary tract symptoms. Digital rectal examination revealed an enlarged multinodular prostate, and the serum prostate-specific antigen (PSA) level was >100 ng/ml. Magnetic resonance imaging showed prostate carcinoma with seminal vesicle involvement. A prostate biopsy showed prostate gland adenocarcinoma. The Gleason score was 3+3. The immunohistochemistry results were as follows: Prostatic acid phosphatase (+++), PSA (+++), P504s (+++), p63 (-) and cytokeratin 34βE12 (-), with a Ki-67 of ~5%. The patient was treated with a bilateral orchiectomy. The testicular pathology showed that the right testis and epididymis were invaded with metastatic adenocarcinoma. The left testis and epididymis were normal. The patient was treated with conventional flutamide endocrine therapy. At present the patient remains in a stable condition after 24 months of follow-up.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Prostatic adenocarcinoma presenting with metastases to the testis and epididymis: A case report

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