Prostatic adenocarcinoma presenting with metastases to the testis and epididymis: A case report

Zhang,Jin; Dong,Mei; Hu,Xiaolei; Liu,Lin; Li,Shen; Li,Chao; Yang,Lijun; Xiao,Yongqiang; Pang,Shujian; Wang,Chuan

doi:10.3892/ol.2015.3920

Prostatic adenocarcinoma presenting with metastases to the testis and epididymis: A case report

Authors:
- Jin Zhang
- Mei Dong
- Xiaolei Hu
- Lin Liu
- Shen Li
- Chao Li
- Lijun Yang
- Yongqiang Xiao
- Shujian Pang
- Chuan Wang
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Affiliations: Department of Urology, The First Hospital of Shijiazhuang, Shijiazhuang, Hebei, P.R. China, Department of Surgery, The Affiliated Hospital of Hebei Science and Technology University, Shijiazhuang, Hebei, P.R. China, Department of Pharmacology, Hebei Medical University, Shijiazhuang, Hebei, P.R. China
Published online on: November 16, 2015 https://doi.org/10.3892/ol.2015.3920
Pages: 792-794

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Abstract

Few cases of testicular metastases from prostate carcinoma have been reported, and asymptomatic metastases of prostate carcinoma to both the testis and epididymis are extremely rare. The current study presents the case of a 69-year-old male with testicular and epididymal metastases from prostate carcinoma. The patient was admitted to The First Hospital of Shijiazhuang with a 2-year history of lower urinary tract symptoms. Digital rectal examination revealed an enlarged multinodular prostate, and the serum prostate-specific antigen (PSA) level was >100 ng/ml. Magnetic resonance imaging showed prostate carcinoma with seminal vesicle involvement. A prostate biopsy showed prostate gland adenocarcinoma. The Gleason score was 3+3. The immunohistochemistry results were as follows: Prostatic acid phosphatase (+++), PSA (+++), P504s (+++), p63 (-) and cytokeratin 34βE12 (-), with a Ki-67 of ~5%. The patient was treated with a bilateral orchiectomy. The testicular pathology showed that the right testis and epididymis were invaded with metastatic adenocarcinoma. The left testis and epididymis were normal. The patient was treated with conventional flutamide endocrine therapy. At present the patient remains in a stable condition after 24 months of follow-up.

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1	Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar : PubMed/NCBI
2	Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI
3	Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, et al: Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet. 380:2095–2128. 2012. View Article : Google Scholar : PubMed/NCBI
4	Miller DC, Hafez KS, Stewart A, Montie JE and Wei JT: Prostate carcinoma presentation, diagnosis, and staging: An update form the National Cancer Data Base. Cancer. 98:1169–1178. 2003. View Article : Google Scholar : PubMed/NCBI
5	Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar : PubMed/NCBI
6	Wang SQ, Mecca PS, Myskowski PL and Slovin SF: Scrotal and penile papules and plaques as the initial manifestation of a cutaneous metastasis of adenocarcinoma of the prostate: Case report and review of the literature. J Cutan Pathol. 35:681–684. 2008. View Article : Google Scholar : PubMed/NCBI
7	Kumar S, Shelley M, Harrison C, Coles B, Wilt TJ and Mason MD: Neo-adjuvant and adjuvant hormone therapy for localized and locally advanced prostate cancer. Cochrane Database Syst Rev. 18:CD0060192006.
8	Gleason DF and Mellinger GT: Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J Urol. 111:58–64. 1974.PubMed/NCBI
9	Parwani AV, Marlow C, Demarzo AM, Mikolajczyk SD, Rittenhouse HG, Veltri RW and Chan TY: Immunohistochemical staining of precursor forms of prostate-specific antigen (proPSA) in metastatic prostate cancer. Am J Surg Pathol. 30:1231–1236. 2006. View Article : Google Scholar : PubMed/NCBI
10	Kessler ER and Flaig TW: Geriatric considerations in the treatment of advanced prostate cancer. F1000 Prime Rep. 6:332014.
11	Antczak A, Kluźniak W, Wokolorczyk D, Kashyap A, Jakubowska A, Gronwald J, Huzarski T, Byrski T, Dębniak T and Masojć B: A common nonsense mutation of the BLM gene and prostate cancer risk and survival. Gene. 532:173–176. 2013. View Article : Google Scholar : PubMed/NCBI
12	Cortesi M, Fridman E, Volkov A, Shilstein SSh, Chechik R, Breskin A, Vartsky D, Raviv G and Ramon J: New prospective for non-invasive detection, grading, size evaluation and tumor location of prostate cancer. Prostate. 70:1701–1708. 2010. View Article : Google Scholar : PubMed/NCBI
13	Bubendorf L, Schöpfer A, Wagner U, Sauter G, Moch H, Willi N, Gasser TC and Mihatsch MJ: Metastatic patterns of prostate cancer: An autopsy study of 1,589 patients. Hum Pathol. 31:578–583. 2000. View Article : Google Scholar : PubMed/NCBI
14	Johansson JE and Lannes P: Metastases to the spermatic cord, epididymis and testicles from carcinoma of the prostate-five cases. Scand J Urol Nephrol. 17:249–251. 1983. View Article : Google Scholar : PubMed/NCBI
15	Pienkos EJ and Jablokow VR: Secondary testicular tumors. Cancer. 30:481–485. 1972. View Article : Google Scholar : PubMed/NCBI
16	Thon W, Mohr W and Altwein JE: Testicular and epididymal metastasis of prostate cancer. Urologe A. 24:287–290. 1985.(In German). PubMed/NCBI
17	Tu SM, Reyes A, Maa A, Bhowmick D, Pisters LL, Pettaway CA, Lin SH, Troncoso P and Logothetis CJ: Prostate carcinoma with testicular or penile metastases. Clinical, pathologic and immunohistochemical features. Cancer. 94:2610–2617. 2002. View Article : Google Scholar : PubMed/NCBI