Central nervous system recurrence of desmoplastic small round cell tumor following aggressive multimodal therapy: A case report

  • Authors:
    • Katsutsugu Umeda
    • Satoshi Saida
    • Hideki Yamaguchi
    • Shinya Okamoto
    • Takeshi Okamoto
    • Itaru Kato
    • Hidefumi Hiramatsu
    • Tsuyoshi Imai
    • Takeshi Kodaira
    • Toshio Heike
    • Souichi Adachi
    • Ken‑Ichiro Watanabe
  • View Affiliations

  • Published online on: November 17, 2015     https://doi.org/10.3892/ol.2015.3928
  • Pages: 856-860
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Abstract

Patients with desmoplastic small round cell tumors (DSRCTs) have an extremely poor outcome despite the use of aggressive therapy. The current study presents the case of 16-year-old male with metastatic DSRCT, in which multimodal therapy, including intensive chemotherapies using frequent autologous stem cell support, gross resection of primary and metastatic lesions, and whole abdominopelvic intensity‑modulated radiation therapy, was administered. Subsequent to these treatments, there was no evidence of active disease. However, cerebellar and pineal body lesions, and bone metastasis to the left humerus were detected 1 year and 2 months after the initial diagnosis. Combination chemotherapy with irinotecan and temozolomide was initially effective against the central nervous system (CNS) metastatic lesions; however, the patient succumbed due to progressive CNS disease after seven courses of combination chemotherapy. Additional studies are required to accumulate information regarding CNS recurrence of DSRCT.
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January-2016
Volume 11 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Umeda K, Saida S, Yamaguchi H, Okamoto S, Okamoto T, Kato I, Hiramatsu H, Imai T, Kodaira T, Heike T, Heike T, et al: Central nervous system recurrence of desmoplastic small round cell tumor following aggressive multimodal therapy: A case report. Oncol Lett 11: 856-860, 2016
APA
Umeda, K., Saida, S., Yamaguchi, H., Okamoto, S., Okamoto, T., Kato, I. ... Watanabe, K. (2016). Central nervous system recurrence of desmoplastic small round cell tumor following aggressive multimodal therapy: A case report. Oncology Letters, 11, 856-860. https://doi.org/10.3892/ol.2015.3928
MLA
Umeda, K., Saida, S., Yamaguchi, H., Okamoto, S., Okamoto, T., Kato, I., Hiramatsu, H., Imai, T., Kodaira, T., Heike, T., Adachi, S., Watanabe, K."Central nervous system recurrence of desmoplastic small round cell tumor following aggressive multimodal therapy: A case report". Oncology Letters 11.1 (2016): 856-860.
Chicago
Umeda, K., Saida, S., Yamaguchi, H., Okamoto, S., Okamoto, T., Kato, I., Hiramatsu, H., Imai, T., Kodaira, T., Heike, T., Adachi, S., Watanabe, K."Central nervous system recurrence of desmoplastic small round cell tumor following aggressive multimodal therapy: A case report". Oncology Letters 11, no. 1 (2016): 856-860. https://doi.org/10.3892/ol.2015.3928