Central nervous system recurrence of desmoplastic small round cell tumor following aggressive multimodal therapy: A case report

Umeda,Katsutsugu; Saida,Satoshi; Yamaguchi,Hideki; Okamoto,Shinya; Okamoto,Takeshi; Kato,Itaru; Hiramatsu,Hidefumi; Imai,Tsuyoshi; Kodaira,Takeshi; Heike,Toshio; Adachi,Souichi; Watanabe,Ken‑Ichiro

doi:10.3892/ol.2015.3928

January-2016 Volume 11 Issue 1

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January-2016 Volume 11 Issue 1

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Case Report

Central nervous system recurrence of desmoplastic small round cell tumor following aggressive multimodal therapy: A case report

Authors:
- Katsutsugu Umeda
- Satoshi Saida
- Hideki Yamaguchi
- Shinya Okamoto
- Takeshi Okamoto
- Itaru Kato
- Hidefumi Hiramatsu
- Tsuyoshi Imai
- Takeshi Kodaira
- Toshio Heike
- Souichi Adachi
- Ken‑Ichiro Watanabe
View Affiliations / Copyright

Affiliations: Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606‑8507, Japan, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606‑8507, Japan, Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606‑8507, Japan, Department of Pediatrics, Otsu Red Cross Hospital, Otsu, Shiga 520‑8511, Japan, Department of Radiation Oncology, Aichi Cancer Center Hospital, Nagoya, Aichi 464‑8681, Japan, Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto 606‑8507, Japan
Pages: 856-860
|
Published online on: November 17, 2015

https://doi.org/10.3892/ol.2015.3928
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Abstract

Patients with desmoplastic small round cell tumors (DSRCTs) have an extremely poor outcome despite the use of aggressive therapy. The current study presents the case of 16-year-old male with metastatic DSRCT, in which multimodal therapy, including intensive chemotherapies using frequent autologous stem cell support, gross resection of primary and metastatic lesions, and whole abdominopelvic intensity‑modulated radiation therapy, was administered. Subsequent to these treatments, there was no evidence of active disease. However, cerebellar and pineal body lesions, and bone metastasis to the left humerus were detected 1 year and 2 months after the initial diagnosis. Combination chemotherapy with irinotecan and temozolomide was initially effective against the central nervous system (CNS) metastatic lesions; however, the patient succumbed due to progressive CNS disease after seven courses of combination chemotherapy. Additional studies are required to accumulate information regarding CNS recurrence of DSRCT.

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1	Jordan AH and Pappo A: Management of desmoplastic small round-cell tumors in children and young adults. J Pediatr Hematol Oncol. 34(Suppl 2): S73–S75. 2012. View Article : Google Scholar : PubMed/NCBI
2	Gerald WL, Ladanyi M, de Alava E, Cuatrecasas M, Kushner BH, LaQuaglia MP and Rosai J: Clinical, pathologic, and molecular spectrum of tumors associated with t(11;22)(p13;q12): Desmoplastic small round-cell tumor and its variants. J Clin Oncol. 16:3028–3036. 1998.PubMed/NCBI
3	Kushner BH, LaQuaglia MP, Wollner N, Meyers PA, Lindsley KL, Ghavimi F, Merchant TE, Boulad F, Cheung NK, Bonilla MA, et al: Desmoplastic small round-cell tumor: Prolonged progression-free survival with aggressive multimodality therapy. J Clin Oncol. 14:1526–1531. 1996.PubMed/NCBI
4	Lal DR, Su WT, Wolden SL, Loh KC, Modak S and LaQuaglia MP: Results of multimodal treatment for desmoplastic small round cell tumors. J Pediatr Surg. 40:251–255. 2005. View Article : Google Scholar : PubMed/NCBI
5	Livingston L and Larson CR: Seminal vesicle cysts with ipsilateral renal agenesis. AJR Am J Roentgenol. 175:177–180. 2000. View Article : Google Scholar : PubMed/NCBI
6	Sayors RL III, Stine KC, Sullivan J, Kepner JL, Wall DA, Bernstein ML, Harris MB, Hayashi R and Vietti TJ: Pediatric Oncology Group: Cyclophosphamide plus topotecan in children with recurrent or refractory solid tumors: A pediatric oncology group phase II study. J Clin Oncol. 19:3463–3469. 2001.PubMed/NCBI
7	Tison V, Cerasoli S, Morigi F, Ladanyi M, Gerald WL and Rosai J: Intracranial desmoplastic small-cell tumor. Report of a case. Am J Surg Pathol. 20:112–117. 1996. View Article : Google Scholar : PubMed/NCBI
8	Neder L, Scheithauer BW, Turel KE, Arnesen MA, Ketterling RP, Jin L, Moynihan TJ, Giannini C and Meyer FB: Desmoplastic small round cell tumor of the central nervous system: Report of two cases and review of the literature. Virchows Arch. 454:431–439. 2009. View Article : Google Scholar : PubMed/NCBI
9	Matthay KK, Brisse H, Couanet D, Couturier J, Bénard J, Mosseri V, Edeline V, Lumbroso J, Valteau-Couanet D and Michon J: Central nervous system metastasis in neuroblastoma: Radiologic, clinical and biologic features in 23 patients. Cancer. 98:155–165. 2003. View Article : Google Scholar : PubMed/NCBI
10	Kuo MF, Lin SM and Tu YK: Solitary cerebellar metastasis from Ewing's sarcoma: Case report and review of the literature. Childs Nerv Syst. 9:428–430. 1993. View Article : Google Scholar : PubMed/NCBI
11	Bagatell R, London WB, Wagner LM, Voss SD, Stewart CF, Maris JM, Kretschmar C and Chon SL: Phase II study of irinotecan and temozolomide in children with relapsed or refractory neuroblastoma: A children's oncology group study. J Clin Oncol. 29:208–213. 2011. View Article : Google Scholar : PubMed/NCBI
12	Wagner LM, McAllister N, Goldsby RE, Rausen AR, McNall-Knapp RY, McCaeville MB and Albritton K: Temozolomide and intravenous irinotecan for treatment of advanced Ewing sarcoma. Pediatr Blood Cancer. 48:132–139. 2007. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Central nervous system recurrence of desmoplastic small round cell tumor following aggressive multimodal therapy: A case report

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