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Article

Baicalein inhibits the migration and invasion of colorectal cancer cells via suppression of the AKT signaling pathway

  • Authors:
    • Xiaojiang Rui
    • Xi Yan
    • Kai Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, 323 Hospital of the People's Liberation Army, Xi'an, Shaanxi 710054, P.R. China
  • Pages: 685-688
    |
    Published online on: November 17, 2015
       https://doi.org/10.3892/ol.2015.3935
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Abstract

The anticancer effect of baicalein has been known for a number of years. However, its anti‑metastatic effect and associated mechanisms in colorectal cancer (CRC) remain unclear. The present study investigated the hypothesis that treatment with baicalein may inhibit the proliferation, motility and invasion of human CRC cell lines via regulation of the protein kinase B (AKT) signaling pathway. Baicalein was demonstrated to significantly inhibit the migration and invasion of CRC cells (P=0.01). Additionally, after treatment with baicalein for 24 h, the protein expression levels of matrix metalloproteinase‑2 (MMP‑2) and MMP‑9 in CRC cells were significantly reduced in a dose‑dependent manner (P=0.01). Furthermore, treatment with baicalein significantly reduced the expression levels of phosphorylated AKT (P=0.01). In conclusion, baicalein appears to inhibit CRC cell migration and invasion by reducing the expression of MMP‑2 and MMP‑9 via suppression of the AKT signaling pathway. Thus, baicalein is a potential novel therapeutic agent for patients with CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Rui X, Yan X and Zhang K: Baicalein inhibits the migration and invasion of colorectal cancer cells via suppression of the AKT signaling pathway. Oncol Lett 11: 685-688, 2016.
APA
Rui, X., Yan, X., & Zhang, K. (2016). Baicalein inhibits the migration and invasion of colorectal cancer cells via suppression of the AKT signaling pathway. Oncology Letters, 11, 685-688. https://doi.org/10.3892/ol.2015.3935
MLA
Rui, X., Yan, X., Zhang, K."Baicalein inhibits the migration and invasion of colorectal cancer cells via suppression of the AKT signaling pathway". Oncology Letters 11.1 (2016): 685-688.
Chicago
Rui, X., Yan, X., Zhang, K."Baicalein inhibits the migration and invasion of colorectal cancer cells via suppression of the AKT signaling pathway". Oncology Letters 11, no. 1 (2016): 685-688. https://doi.org/10.3892/ol.2015.3935
Copy and paste a formatted citation
x
Spandidos Publications style
Rui X, Yan X and Zhang K: Baicalein inhibits the migration and invasion of colorectal cancer cells via suppression of the AKT signaling pathway. Oncol Lett 11: 685-688, 2016.
APA
Rui, X., Yan, X., & Zhang, K. (2016). Baicalein inhibits the migration and invasion of colorectal cancer cells via suppression of the AKT signaling pathway. Oncology Letters, 11, 685-688. https://doi.org/10.3892/ol.2015.3935
MLA
Rui, X., Yan, X., Zhang, K."Baicalein inhibits the migration and invasion of colorectal cancer cells via suppression of the AKT signaling pathway". Oncology Letters 11.1 (2016): 685-688.
Chicago
Rui, X., Yan, X., Zhang, K."Baicalein inhibits the migration and invasion of colorectal cancer cells via suppression of the AKT signaling pathway". Oncology Letters 11, no. 1 (2016): 685-688. https://doi.org/10.3892/ol.2015.3935
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