Paraganglioma of the urinary bladder with chromosome duplications detected by fluorescence in situ hybridization 
in urine exfoliated cells: A case report

Yang,Chunguang; Liu,Zheng; Lan,Ruzhu; Wang,Zhihua; Hu,Zhiquan; Chen,Zhiqiang; Ye,Zhangqun

doi:10.3892/ol.2015.3941

January-2016 Volume 11 Issue 1

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January-2016 Volume 11 Issue 1

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Case Report

Paraganglioma of the urinary bladder with chromosome duplications detected by fluorescence in situ hybridization in urine exfoliated cells: A case report

Authors:
- Chunguang Yang
- Zheng Liu
- Ruzhu Lan
- Zhihua Wang
- Zhiquan Hu
- Zhiqiang Chen
- Zhangqun Ye
View Affiliations / Copyright

Affiliations: Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
Pages: 795-797
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Published online on: November 18, 2015

https://doi.org/10.3892/ol.2015.3941
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Abstract

Paragangliomas of the urinary bladder are rare neoplasms derived from chromaffin tissue with a chromosomal imbalance. Their preoperative diagnosis and assessment of malignant potential remain significant challenges for urologists. The current report presents the case of a 34‑year‑old male who presented with a history of paroxysmal gross hematuria lasting for 7 months. Chromosome duplications were detected by fluorescence in situ hybridization (FISH) in urine exfoliated cells, and the diagnosis was confirmed by histopathology following a transurethral resection. To the best of our knowledge, this is the first reported case of urinary bladder paraganglioma in which chromosomal duplications were detected by FISH in urine exfoliated cells. This may be helpful to its differential diagnosis and malignant potential determination.

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