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Article

Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature

  • Authors:
    • Qiang‑Yong Zhou
    • Hai‑Yan Chen
    • Si‑Meng Yang
    • Yue‑Hua Li
    • Xue‑Qing Wu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
  • Pages: 837-841
    |
    Published online on: November 18, 2015
       https://doi.org/10.3892/ol.2015.3944
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Abstract

To investigate the clinicopathological features, management and prognosis of villoglandular papillary adenocarcinoma (VGPA) of the uterine cervix, the current study presents 4 cases of VGPA of the uterine cervix. The median age of the patients was 55 years (range, 47‑70 years), with all 4 patients presenting with stage Ib disease. Human papillomavirus (HPV) infection was detected in 3 patients; this was mainly HPV‑16. No history of oral contraceptive use was found in these cases. While 2 of the patients underwent a radical hysterectomy with bilateral salpingo‑oophorectomy plus bilateral pelvic lymphadenectomy, 1 patient underwent a radical hysterectomy with bilateral pelvic lymphadenectomy and the remaining patient received a simple total hysterectomy plus post‑operative radiotherapy. Of these patients, only 1 had been correctly diagnosed pre‑operatively. In 2 patients, the biopsy results had been interpreted as cervical adenocarcinoma, and in the third, the biopsy result was of cervical intraepithelial neoplasia. All 4 patients presented with cervical wall invasion, including invasion of the inner two‑thirds in 1 patient. No lymphovascular space invasion or lymph node metastasis was detected. The follow‑up time ranged from 49 to 83 months (median, 64 months), and the patients are currently alive and well, with no evidence of recurrent disease. Taking these results as a whole, VGPA is an uncommon type of cervical adenocarcinoma, characterized by its excellent prognosis. HPV infection is associated with the molecular pathogenesis of VGPA, while oral contraceptive use can be excluded. As the disease has a low pre‑operative diagnostic accuracy, frequent cervical wall invasion and concomitant lesions, conservative treatment strategies should be carefully considered.
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1 

Giordano G, D'Adda T, Gnetti L, Merisio C, Gabrielli M and Melpignano M: Villoglandular adenocarcinoma of the cervix: Two new cases with morphological and molecular study. Int J Gynecol Pathol. 26:199–204. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Young RH and Scully RE: Villoglandular papillary adenocarcinoma of the uterine cervix. A clinicopathologic analysis of 13 cases. Cancer. 63:1773–1779. 1989. View Article : Google Scholar : PubMed/NCBI

3 

Jones MW, Silverberg SG and Kurman RJ: Well-differentiated villoglandular adenocarcinoma of the uterine cervix: A clinicopathological study of 24 cases. Int J Gynecol Pathol. 12:1–7. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Lai JCY, Chen JR, Chen YJ, Hsu CH, Wang TY, Yang YC, Su TH, Tsai TH and Wang KL: Villoglandular Adenocarcinoma of the uterine cervix: An analysis of 12 clinical cases. Int J Gerontol. 5:49–52. 2011. View Article : Google Scholar

5 

Korach J, Machtinger R, Perri T, Vicus D, Segal J, Fridman E and Ben-Baruch G: Villoglandular papillary adenocarcinoma of the uterine cervix: A diagnostic challenge. Acta Obstet Gynecol Scand. 88:355–358. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Hagiwara T, Kaku T, Kobayashi H, Wake N and Saito T: Well-differentiated villoglandular adenocarcinoma of the uterine cervix: Assessment of cytological features by histological subtypes. Acta Cytol. 57:61–68. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Lataifeh IM, Al-Hussaini M, Uzan C, Jaradat I, Duvillard P and Morice P: Villoglandular papillary adenocarcinoma of the cervix: A series of 28 cases including two with lymph node metastasis. Int J Gynecol Cancer. 23:900–905. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Utsugi K, Shimizu Y, Akiyama F, Umezawa S and Hasumi K: Clinicopathologic features of villoglandular papillary adenocarcinoma of the uterine cervix. Gynecol Oncol. 92:64–70. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Khunamornpong S, Siriaunkgul S and Suprasert P: Well-differentiated villoglandular adenocarcinoma of the uterine cervix: Cytomorphologic observation of five cases. Diagn Cytopathol. 26:10–14. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Heatley MK: Villoglandular adenocarcinoma of the uterine cervix-a systematic review of the literature. Histopathology. 51:268–269. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Falcón O, García R, Lubrano A, Morín JC and Andujar M: Successful term delivery following conservative management for villoglandular papillary adenocarcinoma of the uterine cervix: A case report. Gynecol Oncol. 101:168–171. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Dede M, Deveci G, Deveci MS, Yenen MC, Goktolga U, Dilek S and Gunhan O: Villoglandular papillary adenocarcinoma of the uterine cervix in a pregnant woman: A case report and review of literature. Tohoku J Exp Med. 202:305–310. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Heron DE, Axtel A, Gerszten K, Amortegui A, Kelley J, Comerci J and Edwards RP: Villoglandular adenocarcinoma of the cervix recurrent in an episiotomy scar: A case report in a 32-year-old female. Int J Gynecol Cancer. 15:366–371. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Macdonald RD, Kirwan J, Hayat K, Herrington CS and Shawki H: Villoglandular adenocarcinoma of the cervix:clarity is needed on the histological definition for this difficult diagnosis. Gynecol Oncol. 100:192–194. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Rubesa-Mihaljević R, Vrdoljak-Mozetic D, Ostojić DV, Stemberger-Papić S, Sindik N and Krasević M: Villoglandular papillary adenocarcinoma of the uterine cervix with aggressive clinical course-a case report. Coll Antropol. 34:291–294. 2010.

16 

Takai N, Hayashita C, Nakamura S, Narahara H and Matsumoto H: Villoglandular papillary adenocarcinoma of the uterine cervix diagnosed during pregnancy. Eur J Gynaecol Oncol. 31:573–574. 2010.PubMed/NCBI

17 

Jones MW, Kounelis S, Papadaki H, Bakker A, Swalsky PA, Woods J and Finkelstein SD: Well-differentiated villoglandular adenocarcinoma of the uterine cervix: Oncogene/tumor suppressor gene alterations and human papillomavirus genotyping. Int J Gynecol Pathol. 19:110–117. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Yamazawa K, Matsui H, Seki K, Mitsuhashi A, Kawamata Y, Shirasawa H and Sekiya S: Human papillomavirus-positive well-differentiated villoglandular adenocarcinoma of the uterine cervix: A case report and review of the literature. Gynecol Oncol. 77:473–477. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Brinton LA, Herrero R, Reeves WC, de Britton RC, Gaitan E and Tenorio F: Risk factors for cervical cancer by histology. Gynecol Oncol. 51:301–306. 1993. View Article : Google Scholar : PubMed/NCBI

20 

Kleter B, van Doorn LJ, ter Schegget J, Schrauwen L, van Krimpen K, Burger M, ter Harmsel B and Quint W: Novel short-fragment PCR assay for highly sensitive broad-spectrum detection of anogenital human papillomaviruses. Am J Pathol. 153:1731–1739. 1998. View Article : Google Scholar : PubMed/NCBI

21 

Fadare O and Zheng W: Well-differentiated papillary villoglandular adenocarcinoma of the uterine cervix with a focal high-grade component: Is there a need for reassessment? Virchows Arch. 447:883–887. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Bouman A, Oosterhuis GJ, ten Cate Naudin L and van Doorn GA: Villoglandular papillary adenocarcinoma of the cervix. Beware of a wolf in sheep's clothing. Eur J Obstet Gynecol Reprod Biol. 87:183–189. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Collinet P, Prolongeau JF and Vaneecloo S: Villoglandular papillary adenocarcinoma of the uterine cervix. Eur J Obstet Gynecol Reprod Biol. 86:101–103. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Kaku T, Kamura T, Shigematsu T, Sakai K, Nakanami N, Uehira K, Amada S, Kobayashi H, Saito T and Nakano H: Adenocarcinoma of the uterine cervix with predominantly villoglandular papillary growth pattern. Gynecol Oncol. 64:147–152. 1997. View Article : Google Scholar : PubMed/NCBI

25 

Alfsen GC, Reed W and Abeler VM: Reproducibility of classification in non-squamous cell carcinomas of the uterine cervix. Gynecol Oncol. 90:282–289. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Costa MJ, McIlnay KR and Trelford J: Cervical carcinoma with glandular differentiation: histological evaluation predicts disease recurrence in clinical stage I or II patients. Hum Pathol. 26:829–837. 1995. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou QY, Chen HY, Yang SM, Li YH and Wu XQ: Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature. Oncol Lett 11: 837-841, 2016.
APA
Zhou, Q., Chen, H., Yang, S., Li, Y., & Wu, X. (2016). Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature. Oncology Letters, 11, 837-841. https://doi.org/10.3892/ol.2015.3944
MLA
Zhou, Q., Chen, H., Yang, S., Li, Y., Wu, X."Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature". Oncology Letters 11.1 (2016): 837-841.
Chicago
Zhou, Q., Chen, H., Yang, S., Li, Y., Wu, X."Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature". Oncology Letters 11, no. 1 (2016): 837-841. https://doi.org/10.3892/ol.2015.3944
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou QY, Chen HY, Yang SM, Li YH and Wu XQ: Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature. Oncol Lett 11: 837-841, 2016.
APA
Zhou, Q., Chen, H., Yang, S., Li, Y., & Wu, X. (2016). Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature. Oncology Letters, 11, 837-841. https://doi.org/10.3892/ol.2015.3944
MLA
Zhou, Q., Chen, H., Yang, S., Li, Y., Wu, X."Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature". Oncology Letters 11.1 (2016): 837-841.
Chicago
Zhou, Q., Chen, H., Yang, S., Li, Y., Wu, X."Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature". Oncology Letters 11, no. 1 (2016): 837-841. https://doi.org/10.3892/ol.2015.3944
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