Fusion of platelet‑derived growth factor receptor β to CEV14 gene in chronic myelomonocytic leukemia: A case report and review of the literature

  • Authors:
    • Sheng‑Lan Gong
    • Meng‑Qiao Guo
    • Gu‑Sheng Tang
    • Chun‑Ling Zhang
    • Hui‑Ying Qiu
    • Xiao‑Xia Hu
    • Jian‑Min Yang
  • View Affiliations

  • Published online on: November 18, 2015     https://doi.org/10.3892/ol.2015.3949
  • Pages: 770-774
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Abstract

Myeloid tumor possessing platelet‑derived growth factor receptor β (PDGFRβ) gene rearrangement is a rare hematological malignancy, which presents with typical characteristics of myeloid proliferation disorders and eosinophilia. In the present study, an elderly chronic myelomonocytic leukemia patient was diagnosed with chromosome rearrangement. Fluorescence in situ hybridization (FISH) was conducted with a PDGFRβ isolate probe, and gene translocation between PDGFRβ on chromosome 5 and genes on the chromosomes of group D (13‑15) was detected. Karyotype analysis revealed a chromosome 5 break, and PDGFRβ‑thyroid hormone receptor interactor 11 (CEV14) gene fusion was confirmed via reverse transcription‑polymerase chain reaction (RT‑PCR), which additionally revealed the chromosome rearrangement t(5;14)(q33;q32). Due to the correlation between PDGFRβ‑CEV14 expression and effectiveness of treatment with tyrosine kinase inhibitors, this fusion gene is considered to be an oncogene. In the present study, an elderly patient was diagnosed with a myeloid tumor associated with the fusion gene PDGFRβ‑CEV14, using the methods of FISH and RT‑PCR. These methods were confirmed to be of significant value in improving diagnosis, guiding treatment and increasing the cure rate of patients, due to their ability to detect multiple rearrangement genes associated with PDGFRβ in myelodysplastic and myeloproliferative neoplasms.
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January-2016
Volume 11 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Gong SL, Guo MQ, Tang GS, Zhang CL, Qiu HY, Hu XX and Yang JM: Fusion of platelet‑derived growth factor receptor β to CEV14 gene in chronic myelomonocytic leukemia: A case report and review of the literature. Oncol Lett 11: 770-774, 2016
APA
Gong, S., Guo, M., Tang, G., Zhang, C., Qiu, H., Hu, X., & Yang, J. (2016). Fusion of platelet‑derived growth factor receptor β to CEV14 gene in chronic myelomonocytic leukemia: A case report and review of the literature. Oncology Letters, 11, 770-774. https://doi.org/10.3892/ol.2015.3949
MLA
Gong, S., Guo, M., Tang, G., Zhang, C., Qiu, H., Hu, X., Yang, J."Fusion of platelet‑derived growth factor receptor β to CEV14 gene in chronic myelomonocytic leukemia: A case report and review of the literature". Oncology Letters 11.1 (2016): 770-774.
Chicago
Gong, S., Guo, M., Tang, G., Zhang, C., Qiu, H., Hu, X., Yang, J."Fusion of platelet‑derived growth factor receptor β to CEV14 gene in chronic myelomonocytic leukemia: A case report and review of the literature". Oncology Letters 11, no. 1 (2016): 770-774. https://doi.org/10.3892/ol.2015.3949