Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2016 Volume 11 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2016 Volume 11 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Clinicopathological features of dermatofibrosarcoma protuberans

  • Authors:
    • Noppadol Larbcharoensub
    • Jitchai Kayankarnnavee
    • Suda Sanpaphant
    • Kidakorn Kiranantawat
    • Chewarat Wirojtananugoon
    • Vorachai Sirikulchayanonta
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand, Department of Radiology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
  • Pages: 661-667
    |
    Published online on: November 24, 2015
       https://doi.org/10.3892/ol.2015.3966
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Dermatofibrosarcoma protuberans (DFSP) is a superficial cutaneous tumor of low malignant potential characterized by a high rate of local recurrence. The histopathological appearance shows uniform spindle neoplastic cells arranged in a predominantly storiform pattern, typically with positive staining for cluster of differentiation (CD)34 and vimentin on immunohistochemistry. A minority of cases of DFSP have areas of sarcomatous transformation. Wide surgical excision is the cornerstone of treatment for DFSP. The objective of the present study was to determine the clinicopathological features of DFSP. Pathological records were searched for cases of DFSP in the database of the Department of Pathology, Faculty of Medicine Ramathibodi Hospital (Mahidol University, Bangkok, Thailand) between 1994 and 2013. The results showed 68 cases with DFSP. The mean age at diagnosis was 40 years (range, 3‑86 years). Among this group of patients, 26 cases (38.2%) experienced local recurrence and 6 (8.8%) exhibited sarcomatous transformation of DFSP. The factors that predict the recurrence of DFSP are an incorrect first pathological diagnosis and an inadequate surgical margin. The factors that predict the sarcomatous transformation of DFSP are a larger tumor size and an incorrect first pathological diagnosis. In patients who have tumors with spindle cells arranged in a storiform pattern, CD34 immunohistochemical staining provides the definitive diagnosis. Exact histopathological categorization is important to select the appropriate treatment and predict the clinical outcome.
View Figures

Figure 1

Figure 2

View References

1 

Mentzel T, Peeutour F, Lazar A and Coindre JM: Dermatofibrosarcoma protuberans. World Health Organization (WHO) Classification of Tumours of Soft tissue and Bone. Pathology and Genetics. Fletcher CDM, Bridge JA, Hogendoorn P and Martens F: 5:(4th). (Lyon). IARC Press. 77–79. 2013.

2 

Weyers W, Mentzel T, Kasper RC, Tosti A, Iorizzo M, Zelger B and Caputo R: In: World Health Organization Classification of Tumours. Pathology and Genetics Skin Tumours. Fibrous, fibrohistiocytic and histiocytic tumours. Le Boit PE, Burg G, Weedon D and Sarasin A: (Lyon). IARC Press. 259–261. 2002.

3 

Kempson RL, Fletcher CDM, Evans HL, Hendrickson MR and Sibley RK: Atlas of Tumor Pathology. Tumors of Soft Tissues. 3rd series. Fascicle 30. Armed Forces Institute of Pathology (Washington, DC). 138–148. 2001.

4 

Goldblum JR, Folpe AL and Weiss SW: Fibrohistocytic tumors of intermediate malignancy. Enzinger and Weisss soft tissue tumors (6th). (Philadelphia, PA). Elsevier Saunders. 387–400. 2013.

5 

Darier J and Ferrand M: Dermatofibromes progressifs et récidivants ou fibrosarcomes de la peau. Ann Dermatol Syphiligr (Paris). 5:545–562. 1924.

6 

Prieto VG, Reed JA and Shea CR: CD34 immunoreactivity distinguishes between scar tissue and residual tumor in re-excisional specimens of dermatofibrosarcoma protuberans. J Cutan Pathol. 21:324–329. 1994. View Article : Google Scholar : PubMed/NCBI

7 

Llombart B, Serra-Guillén C, Monteagudo C, López Guerrero JA and Sanmartín O: Dermatofibrosarcoma protuberans: A comprehensive review and update on diagnosis and management. Semin Diagn Pathol. 30:13–28. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Erdem O, Wyatt AJ, Lin E, Wang X and Prieto VG: Dermatofibrosarcoma protuberans treated with wide local excision and followed at a cancer hospital: Prognostic significance of clinicopathologic variables. Am J Dermatopathol. 34:24–34. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Stivala A, Lombardo GA, Pompili G, Tarico MS, Fraggetta F and Perrotta RE: Dermatofibrosarcoma protuberans: Our experience of 59 cases. Oncol Lett. 4:1047–1055. 2012.PubMed/NCBI

10 

Archontaki M, Korkolis DP, Arnogiannaki N, Konstantinidou C, Georgopoulos S, Dendrinos P, Zarkadas G and Kokkalis G: Dermatofibrosarcoma protuberans: A case series of 16 patients treated in a single institution with literature review. Anticancer Res. 30:3775–3779. 2010.PubMed/NCBI

11 

Fiore M, Miceli R, Mussi C, Lo Vullo S, Mariani L, Lozza L, Collini P, Olmi P, Casali PG and Gronchi A: Dermatofibrosarcoma protuberans treated at a single institution: A surgical disease with a high cure rate. J Clin Oncol. 23:7669–7675. 2005. View Article : Google Scholar : PubMed/NCBI

12 

DuBay D, Cimmino V, Lowe L, Johnson TM and Sondak VK: Low recurrence rate after surgery for dermatofibrosarcoma protuberans: A multidisciplinary approach from a single institution. Cancer. 100:1008–1016. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Lemm D, Mügge LO, Mentzel T and Höffken K: Current treatment options in dermatofibrosarcoma protuberans. J Cancer Res Clin Oncol. 135:653–665. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Connelly JH and Evans HL: Dermatofibrosarcoma protuberans. A clinicopathologic review with emphasis on fibrosarcomatous areas. Am J Surg Pathol. 16:921–925. 1992. View Article : Google Scholar : PubMed/NCBI

15 

Sato N, Kimura K and Tomita Y: Recurrent dermatofibrosarcoma protuberans with myxoid and fibrosarcomatous changes paralleled by loss of CD34 expression. J Dermatol. 22:665–672. 1995. View Article : Google Scholar : PubMed/NCBI

16 

Mentzel T, Beham A, Katenkamp D, Dei Tos AP and Fletcher CD: Fibrosarcomatous (‘high-grade’) dermatofibrosarcoma protuberans: Clinicopathologic and immunohistochemical study of a series of 41 cases with emphasis on prognostic significance. Am J Surg Pathol. 22:576–587. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Goldblum JR, Reith JD and Weiss SW: Sarcomas arising in dermatofibrosarcoma protuberans: A reappraisal of biologic behavior in eighteen cases treated by wide local excision with extended clinical follow up. Am J Surg Pathol. 24:1125–1130. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Abbott JJ, Oliveira AM and Nascimento AG: The prognostic significance of fibrosarcomatous transformation in dermatofibrosarcoma protuberans. Am J Surg Pathol. 30:436–443. 2006. View Article : Google Scholar : PubMed/NCBI

19 

McArthur G: Dermatofibrosarcoma protuberans: Recent clinical progress. Ann Surg Oncol. 14:2876–2886. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Larbcharoensub N, Kayankarnnavee J, Sanpaphant S, Kiranantawat K, Wirojtananugoon C and Sirikulchayanonta V: Clinicopathological features of dermatofibrosarcoma protuberans. Oncol Lett 11: 661-667, 2016.
APA
Larbcharoensub, N., Kayankarnnavee, J., Sanpaphant, S., Kiranantawat, K., Wirojtananugoon, C., & Sirikulchayanonta, V. (2016). Clinicopathological features of dermatofibrosarcoma protuberans. Oncology Letters, 11, 661-667. https://doi.org/10.3892/ol.2015.3966
MLA
Larbcharoensub, N., Kayankarnnavee, J., Sanpaphant, S., Kiranantawat, K., Wirojtananugoon, C., Sirikulchayanonta, V."Clinicopathological features of dermatofibrosarcoma protuberans". Oncology Letters 11.1 (2016): 661-667.
Chicago
Larbcharoensub, N., Kayankarnnavee, J., Sanpaphant, S., Kiranantawat, K., Wirojtananugoon, C., Sirikulchayanonta, V."Clinicopathological features of dermatofibrosarcoma protuberans". Oncology Letters 11, no. 1 (2016): 661-667. https://doi.org/10.3892/ol.2015.3966
Copy and paste a formatted citation
x
Spandidos Publications style
Larbcharoensub N, Kayankarnnavee J, Sanpaphant S, Kiranantawat K, Wirojtananugoon C and Sirikulchayanonta V: Clinicopathological features of dermatofibrosarcoma protuberans. Oncol Lett 11: 661-667, 2016.
APA
Larbcharoensub, N., Kayankarnnavee, J., Sanpaphant, S., Kiranantawat, K., Wirojtananugoon, C., & Sirikulchayanonta, V. (2016). Clinicopathological features of dermatofibrosarcoma protuberans. Oncology Letters, 11, 661-667. https://doi.org/10.3892/ol.2015.3966
MLA
Larbcharoensub, N., Kayankarnnavee, J., Sanpaphant, S., Kiranantawat, K., Wirojtananugoon, C., Sirikulchayanonta, V."Clinicopathological features of dermatofibrosarcoma protuberans". Oncology Letters 11.1 (2016): 661-667.
Chicago
Larbcharoensub, N., Kayankarnnavee, J., Sanpaphant, S., Kiranantawat, K., Wirojtananugoon, C., Sirikulchayanonta, V."Clinicopathological features of dermatofibrosarcoma protuberans". Oncology Letters 11, no. 1 (2016): 661-667. https://doi.org/10.3892/ol.2015.3966
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team